| UniProt ID | GPC5_HUMAN | |
|---|---|---|
| UniProt AC | P78333 | |
| Protein Name | Glypican-5 | |
| Gene Name | GPC5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 572 | |
| Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor Extracellular side. Secreted glypican-5: Secreted, extracellular space. |
|
| Protein Description | Cell surface proteoglycan that bears heparan sulfate.. | |
| Protein Sequence | MDAQTWPVGFRCLLLLALVGSARSEGVQTCEEVRKLFQWRLLGAVRGLPDSPRAGPDLQVCISKKPTCCTRKMEERYQIAARQDMQQFLQTSSSTLKFLISRNAAAFQETLETLIKQAENYTSILFCSTYRNMALEAAASVQEFFTDVGLYLFGADVNPEEFVNRFFDSLFPLVYNHLINPGVTDSSLEYSECIRMARRDVSPFGNIPQRVMGQMGRSLLPSRTFLQALNLGIEVINTTDYLHFSKECSRALLKMQYCPHCQGLALTKPCMGYCLNVMRGCLAHMAELNPHWHAYIRSLEELSDAMHGTYDIGHVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRPVRTPTQSPRCSFDQSKEKHGMKTTTRNSEETLANRRKEFINSLRLYRSFYGGLADQLCANELAAADGLPCWNGEDIVKSYTQRVVGNGIKAQSGNPEVKVKGIDPVINQIIDKLKHVVQLLQGRSPKPDKWELLQLGSGGGMVEQVSGDCDDEDGCGGSGSGEVKRTLKITDWMPDDMNFSDVKQIHQTDTGSTLDTTGAGCAVATESMTFTLISVVMLLPGIW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 67 | Phosphorylation | VCISKKPTCCTRKME EEECCCCCCCCHHHH | 29.14 | 28555341 | |
| 120 | N-linked_Glycosylation | TLIKQAENYTSILFC HHHHHHCCCCHHEEE | 48.69 | UniProtKB CARBOHYD | |
| 218 | Phosphorylation | VMGQMGRSLLPSRTF HHHHHHHHCCCCHHH | 28.64 | 26552605 | |
| 222 | Phosphorylation | MGRSLLPSRTFLQAL HHHHCCCCHHHHHHH | 43.87 | 25278378 | |
| 224 | Phosphorylation | RSLLPSRTFLQALNL HHCCCCHHHHHHHHH | 32.79 | - | |
| 237 | N-linked_Glycosylation | NLGIEVINTTDYLHF HHCCEEEECCCHHHC | 41.94 | UniProtKB CARBOHYD | |
| 257 | Phosphorylation | RALLKMQYCPHCQGL HHHHHHHCCCCCCCE | 12.40 | - | |
| 385 | Ubiquitination | ETLANRRKEFINSLR HHHHHHHHHHHHHHH | 54.46 | 29967540 | |
| 394 | Phosphorylation | FINSLRLYRSFYGGL HHHHHHHHHHHHHHH | 9.58 | - | |
| 441 | O-linked_Glycosylation | GNGIKAQSGNPEVKV CCCCCCCCCCCCCEE | 45.45 | - | |
| 486 | O-linked_Glycosylation | WELLQLGSGGGMVEQ EEEEECCCCCCCEEE | 42.74 | - | |
| 495 | O-linked_Glycosylation | GGMVEQVSGDCDDED CCCEEEECCCCCCCC | 28.71 | - | |
| 507 | O-linked_Glycosylation | DEDGCGGSGSGEVKR CCCCCCCCCCCHHEE | 18.31 | - | |
| 509 | O-linked_Glycosylation | DGCGGSGSGEVKRTL CCCCCCCCCHHEEEE | 33.21 | - | |
| 527 | N-linked_Glycosylation | DWMPDDMNFSDVKQI CCCCCCCCHHHCCHH | 40.02 | UniProtKB CARBOHYD | |
| 541 | Phosphorylation | IHQTDTGSTLDTTGA HEECCCCCCCCCCCC | 28.08 | 30576142 | |
| 545 | Phosphorylation | DTGSTLDTTGAGCAV CCCCCCCCCCCCCEE | 30.18 | 30576142 | |
| 554 | Phosphorylation | GAGCAVATESMTFTL CCCCEEECHHHHHHH | 23.22 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GPC5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GPC5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GPC5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GPC5_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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