BIRC6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BIRC6_MOUSE
• UniProt AC: O88738
• Protein Name: Baculoviral IAP repeat-containing protein 6
• Gene Name: Birc6
• Organism: Mus musculus (Mouse).
• Sequence Length: 4882
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane . Endosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody, Midbody ring . Exhibits cell cycle-dependent localization. Concentrates i
• Protein Description: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development..
• Protein Sequence: MVTGCGAAPPGTVTERLPSVIVLSAGRKMAAAAAEASGPSCSSAAAAAGAGAAGVSEWLVLRDGCMRCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACIEKIDVSSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRLSYLLPSARPELGVGPGRSVDRALMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKGEHTQNVPLSVTLATSPAQLPSADGADRIACFGSGSCPQFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSRRPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGANPSLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQMNNIMSKSLHDDGFTVPQIIEMELDNQEQLLLQDPPVTYIQQFADAAASLTSPDSEKWNSVFPKPGALVQCLRLPKFAEEETLCIDSITPCADGIHLLVGLRTCSVESLSAINQVEALNNLNKLNSALCNRRKGDLESNLAVVNGANISVIQHESPADVPEHLLIRPEQRNVVSGGYLVLYKMNYTTRIVTLEEEPVKIQHIKDPQDTITSLILLPPDILDNREDDCEEPAEEMQLASKNGIEREKKSDISTLGHLVVTTQGGYVKVLDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGELHFLQIGGTCDDIDEADILVDGSLSKGIEPALEGSRPLSNPSSPGISGVELLVDQPFTLEILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQTDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITSVPQIQVTLLKNKAPGLGKANALNIEVEHNGNPSLVDLNEEMHHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGMLTLTSPKLVKGMAGGKYRSFLIHVKAVSDRGAADEMCSSGLRPVVRLPSLKQQGHKGYSLASLLAKVAAGKEKSSNVKNENAGGTRKSENLRGCDLLQEVSVTIRRFKKTSICKERVQRCAMLQFSEFHEKLLNTLCRRSDDGQVTEHAQSLVLDALCWLAGVHSNGSGSSKEGNECLLSKTRKCLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCEPCQPGFGSVLLKALLDNMCFLPAAATGGSVYWYFVLLNYVKDEDLAGCSTACAALLTAVSRQLQDRLTPLEALLQTRYGLYSSPFDPVLFDLEMSGSSWKTVYSSSTAVQSDEIDLSDVLSGNGRVSSCTAAEGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDASTFTVSSFGVPPAVGGLSSGTVGEASTALSSAAQVALQSLSHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASAAAAAAAGPVHNAVPSNPVAAPGFFIHPSDVIPPTPKTTPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAVNLAAQNKNSSKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPILLTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITVIGRYGSTNARAKIPLGFYYGHSYILPWESELKLMHDPLRGEGESASQPEIDQHLAMMVALQEDIQCRYNLACHRLEALLQSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCIQLQLQLNLAHNAVQRLKVAIGASRKLLNETSGPEDLIQTSSTEQLRTIVRYLLDTLLSLLHSSNGHSVPAVLQSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVLQELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPELSMHRRTEGVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGKDRERFLTGNQWSFINNNLHTQNLNRSSKGGSSLDRLYSRKIRKQLVHHKQQLNLLKAKQKALVEQMEKEKIQSNKGSSYKLLVEQAKLKQATSKHFKDLIRLRRTAEWSRSNLDTEVTTTKESPEIEPLPFTLAHDRCISVVQKLVLFLLSMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWGGAWAQYSLTCMLQDILAGELLAPVAAEAMEECTVSEDVGATAGDSDDSLQQSPAQLLETIDEPLTHEIAGTPPLSSLEKDKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTWYDYWGADYGTYNYNPYIGGLGMPVAKPPSNTEKNGSQTVSVSVSQALDARLEVGLEQQAELMLKMMSTLEADSILQALTNTSPTFSQSPTGTDDSLLGNLQPANQNSQLMIQLSSVPMLNVCFNKLFSMLQVHHVQLESLLQLWLTLSLNSSSSGNKENGADIFLYNANRIPVISLNQASIASFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSSIGIQETTAHLLVSDPNLIHVLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSELLLKLIHILSTERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSRSGSDSSAGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSSNREYSARVSVTTNTTDSVSDEEKVSGGKDVNGSSASTPGSPACVADLVLANQQIMSQILSALGLCNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTYMACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAIVNTARSMVSTIMKFLDSGPNKAVDSTLKTRILASEPDNAEGIHNFAPLGTITSSSPTAQPAEVLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPSAVLLKEIHIQPHLASLATCPSSVSVEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLGLTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMASAAAPTANLLQTCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLFGRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSAKMAALKRSGRMNYMCPSSSAVEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLDRELFELLFNWSMSLPCNVVLKKAVDSLLCSMCHIHPNYFSLLMGWMGIIPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQAPLSLTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISYSESIAQSVDNSQDKLRRHHVPQHCNKMPITADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLCHSGSTAGGHNLGAQQSSTRSASHSSATTTVLTTQQRTAIENATVAFFLQCISCHPNNQKLMAQVLCELFQTAPQRGSLPTSGNISGFVRRLFLQLMLEDEKVTMFLQSPCPLYKGRINATSHVIQHPMFGAGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEEKEKVKAENGFQDNYSVVVASGLKSQSKRAMASTPPRPPSRRGRTIPDKIGSASSSADAASKIITVPVFHLFHRLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSKVITDPSLSKTDSFKRLHPEKDHGDLVGSCPEDEALTPSDECMDGVLDESLLETCPIQSPLQVFAGMGGLALIAERLPMLYPEVIQQVSAPVIASTTQEKPKDSDQFEWVTIEQSGELVYEAPETIAAEPPPVKSAVQATSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHILQSPSANVLPTLPFHVLRSLFSATPLTTDDGVLLRRMALEIGALHLILVCLSALSHHAPRVPNSSLSQTEPQVSNSHNPTSAEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHVTCLLQVLASYINPMSGAVNGEAQASPESRAQNSSALPSVLLELLSQSCLIPAMSSYLRNDSVLDMARHVPLYRALLELLRAIASCTSMVPLLLPLSTENGEEEEDEQSECQTSVGTLLAKMKTCVDTYTNRLRSKRENVKAGVKPDAPDQEPEGLALLVPDIQRTAEIVHAATANLRQANQEKKLGEYSKKVVMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDDDGKLGFKVNYHYMSQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAMLEQIRNPSPCFKEVIHKHFYLKRIELMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRHTAQLREELLKLPCPEGLDPDIEDASPVCRATAGAEDTLTHDHVNPSSSKDLPSDFQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	LPSVIVLSAGRKMAA CCCEEEEECCHHHHH	20.13	26239621
95	Ubiquitination	VTSRGTIKVIDGTSG HHCCCEEEEECCCCC	32.73	22790023
95	Ubiquitination	VTSRGTIKVIDGTSG HHCCCEEEEECCCCC	32.73	22790023
135	Phosphorylation	KVIFVDDYAVGCRKD EEEEECCCCCCCCCC	9.95	18563927
264	Phosphorylation	SVMDRLSYLLPSARP HHHHHHHHHCCCCCC	19.49	26239621
443	Phosphorylation	IVQQLILSGDPSSGV HHHHHHHCCCCCCCC	33.87	29899451
447	Phosphorylation	LILSGDPSSGVDSRR HHHCCCCCCCCCCCC	44.45	25338131
448	Phosphorylation	ILSGDPSSGVDSRRP HHCCCCCCCCCCCCC	48.50	20415495
452	Phosphorylation	DPSSGVDSRRPTLAW CCCCCCCCCCCCEEE	27.99	27180971
456	Phosphorylation	GVDSRRPTLAWLEDS CCCCCCCCEEECCCC	27.57	22817900
463	Phosphorylation	TLAWLEDSSSCSDIP CEEECCCCCCCCCCC	18.12	25293948
464	Phosphorylation	LAWLEDSSSCSDIPK EEECCCCCCCCCCCC	47.92	30352176
465	Phosphorylation	AWLEDSSSCSDIPKL EECCCCCCCCCCCCC	22.92	25521595
467	Phosphorylation	LEDSSSCSDIPKLEG CCCCCCCCCCCCCCC	40.29	29472430
476	Phosphorylation	IPKLEGDSDDLLEDS CCCCCCCCCCCCCCC	43.83	25521595
483	Phosphorylation	SDDLLEDSDSEEHSR CCCCCCCCCCCCHHC	33.39	25521595
485	Phosphorylation	DLLEDSDSEEHSRSD CCCCCCCCCCHHCCC	49.16	27742792
489	Phosphorylation	DSDSEEHSRSDSVTG CCCCCCHHCCCCCCC	36.44	27742792
491	Phosphorylation	DSEEHSRSDSVTGHT CCCCHHCCCCCCCCC	36.93	21743459
493	Phosphorylation	EEHSRSDSVTGHTSQ CCHHCCCCCCCCCCH	23.87	26824392
495	Phosphorylation	HSRSDSVTGHTSQKE HHCCCCCCCCCCHHH	27.48	21743459
498	Phosphorylation	SDSVTGHTSQKEAME CCCCCCCCCHHHHHH	33.91	22210690
499	Phosphorylation	DSVTGHTSQKEAMEV CCCCCCCCHHHHHHH	33.31	22210690
546	Phosphorylation	EELGANPSLTNSKSE HHHCCCCCCCCCCCH	47.86	25521595
548	Phosphorylation	LGANPSLTNSKSEKT HCCCCCCCCCCCHHH	41.61	28066266
550	Phosphorylation	ANPSLTNSKSEKTKE CCCCCCCCCCHHHHH	32.12	28066266
551	Ubiquitination	NPSLTNSKSEKTKEK CCCCCCCCCHHHHHH	65.78	22790023
551	Ubiquitination	NPSLTNSKSEKTKEK CCCCCCCCCHHHHHH	65.78	22790023
555	Phosphorylation	TNSKSEKTKEKHQEQ CCCCCHHHHHHHHHH	40.14	22807455
577	Phosphorylation	LLAGGLLTYKSPATS EEECCEEEECCCCCC	33.67	26239621
578	Phosphorylation	LAGGLLTYKSPATSP EECCEEEECCCCCCC	14.94	26745281
580	Phosphorylation	GGLLTYKSPATSPIS CCEEEECCCCCCCCC	14.89	23684622
583	Phosphorylation	LTYKSPATSPISSNS EEECCCCCCCCCCCC	38.12	23684622
584	Phosphorylation	TYKSPATSPISSNSH EECCCCCCCCCCCCC	23.49	26824392
587	Phosphorylation	SPATSPISSNSHRSL CCCCCCCCCCCCCCC	27.18	26745281
588	Phosphorylation	PATSPISSNSHRSLD CCCCCCCCCCCCCCC	42.97	26745281
590	Phosphorylation	TSPISSNSHRSLDGL CCCCCCCCCCCCCCC	23.40	26745281
593	Phosphorylation	ISSNSHRSLDGLSRT CCCCCCCCCCCCCCC	25.95	25521595
598	Phosphorylation	HRSLDGLSRTQGESI CCCCCCCCCCCCCCC	38.52	25293948
600	Phosphorylation	SLDGLSRTQGESISE CCCCCCCCCCCCCCC	37.23	22802335
604	Phosphorylation	LSRTQGESISEQGST CCCCCCCCCCCCCCC	37.93	26525534
606	Phosphorylation	RTQGESISEQGSTDN CCCCCCCCCCCCCCC	32.90	22802335
615	Phosphorylation	QGSTDNESCTNSELN CCCCCCCCCCCHHCC	32.28	25293948
617	Phosphorylation	STDNESCTNSELNSP CCCCCCCCCHHCCCH	51.57	26525534
619	Phosphorylation	DNESCTNSELNSPLV CCCCCCCHHCCCHHH	25.88	22802335
623	Phosphorylation	CTNSELNSPLVRRTL CCCHHCCCHHHHHHH	32.03	22802335
703	Phosphorylation	DAAASLTSPDSEKWN HHHHHCCCCCHHHHH	31.81	25338131
1120	Phosphorylation	VLNSNITSVPQIQVT EECCCCCCCCEEEEE	28.18	22802335
1127	Phosphorylation	SVPQIQVTLLKNKAP CCCEEEEEEECCCCC	15.25	22802335
1225	Phosphorylation	GGKYRSFLIHVKAVS CCCEEEEEEEEEECC	2.53	24719451
1253	Phosphorylation	RPVVRLPSLKQQGHK CCEEECHHHHHCCCC	53.44	25266776
1266	Phosphorylation	HKGYSLASLLAKVAA CCCCCHHHHHHHHHC	29.25	22006019
1305	Phosphorylation	CDLLQEVSVTIRRFK CCCHHHHHHHHHHCC	16.88	25195567
1652	Ubiquitination	EKQQQLLKLQQQKAK HHHHHHHHHHHHHHH	53.49	22790023
1652	Ubiquitination	EKQQQLLKLQQQKAK HHHHHHHHHHHHHHH	53.49	22790023
1724	Phosphorylation	LFMTPPLTPPNEAVS CEECCCCCCCCCCEE	42.34	-
2207	Ubiquitination	EDEAAAAKKPLNGKD CHHHHHHCCCCCCCC	50.64	22790023
2207	Ubiquitination	EDEAAAAKKPLNGKD CHHHHHHCCCCCCCC	50.64	22790023
2216	Phosphorylation	PLNGKDRERFLTGNQ CCCCCCHHHCCCCCC	58.90	24719451
2220	Phosphorylation	KDRERFLTGNQWSFI CCHHHCCCCCCEEHH	31.23	-
2223	Phosphorylation	ERFLTGNQWSFINNN HHCCCCCCEEHHCCC	38.24	24719451
2239	Phosphorylation	HTQNLNRSSKGGSSL CCCCCCCCCCCCCCH	35.02	-
2240	Phosphorylation	TQNLNRSSKGGSSLD CCCCCCCCCCCCCHH	31.89	-
2244	Phosphorylation	NRSSKGGSSLDRLYS CCCCCCCCCHHHHHH	36.07	25266776
2245	Phosphorylation	RSSKGGSSLDRLYSR CCCCCCCCHHHHHHH	37.25	25266776
2251	Phosphorylation	SSLDRLYSRKIRKQL CCHHHHHHHHHHHHH	31.52	-
2253	Ubiquitination	LDRLYSRKIRKQLVH HHHHHHHHHHHHHHH	40.71	-
2281	Ubiquitination	ALVEQMEKEKIQSNK HHHHHHHHHHHHCCC	59.99	22790023
2281	Ubiquitination	ALVEQMEKEKIQSNK HHHHHHHHHHHHCCC	59.99	22790023
2288	Ubiquitination	KEKIQSNKGSSYKLL HHHHHCCCCHHHHHH	66.47	-
2293	Ubiquitination	SNKGSSYKLLVEQAK CCCCHHHHHHHHHHH	36.97	22790023
2293	Ubiquitination	SNKGSSYKLLVEQAK CCCCHHHHHHHHHHH	36.97	22790023
2300	Ubiquitination	KLLVEQAKLKQATSK HHHHHHHHHHHHHHH	56.78	22790023
2300	Ubiquitination	KLLVEQAKLKQATSK HHHHHHHHHHHHHHH	56.78	22790023
2307	Acetylation	KLKQATSKHFKDLIR HHHHHHHHHHHHHHH	49.02	7612811
2310	Acetylation	QATSKHFKDLIRLRR HHHHHHHHHHHHHHH	51.88	7612823
2336	Phosphorylation	EVTTTKESPEIEPLP CEEECCCCCCCCCCC	29.41	19060867
2498	Phosphorylation	IAGTPPLSSLEKDKE HCCCCCCHHCCCCCC	38.35	27149854
2499	Phosphorylation	AGTPPLSSLEKDKEI CCCCCCHHCCCCCCC	48.51	27149854
2797	Phosphorylation	SGTSPHGTNQHSPQV HCCCCCCCCCCCCCC	28.77	22802335
2902	Phosphorylation	TCSDKVMSRSGSDSS CCCHHHHHCCCCCCH	26.70	-
2904	Phosphorylation	SDKVMSRSGSDSSAG CHHHHHCCCCCCHHH	35.03	-
2973	Phosphorylation	RVSVTTNTTDSVSDE EEEEEECCCCCCCHH	29.86	25619855
2974	Phosphorylation	VSVTTNTTDSVSDEE EEEEECCCCCCCHHH	28.48	25619855
2976	Phosphorylation	VTTNTTDSVSDEEKV EEECCCCCCCHHHHC	22.79	25619855
2978	Phosphorylation	TNTTDSVSDEEKVSG ECCCCCCCHHHHCCC	43.17	25521595
3071	Phosphorylation	TTLSKKASTVHMMLQ HHHCCCCCHHHHHHH	39.58	26239621
3072	Phosphorylation	TLSKKASTVHMMLQP HHCCCCCHHHHHHHH	21.20	26239621
3147	Phosphorylation	AIVNTARSMVSTIMK HHHHHHHHHHHHHHH	22.52	22871156
3158	Phosphorylation	TIMKFLDSGPNKAVD HHHHHHHCCCCHHHC	59.29	22871156
3162	Ubiquitination	FLDSGPNKAVDSTLK HHHCCCCHHHCCHHH	53.58	22790023
3162	Ubiquitination	FLDSGPNKAVDSTLK HHHCCCCHHHCCHHH	53.58	22790023
3169	Ubiquitination	KAVDSTLKTRILASE HHHCCHHHHHHHHCC	35.53	-
3312	Phosphorylation	LHRPRDASTLGLSQI CCCCCCHHHHCHHHH	28.58	25338131
3481	Phosphorylation	QALLKWVSDSAKMAA HHHHHHHCHHHHHHH	25.41	21454597
3483	Phosphorylation	LLKWVSDSAKMAALK HHHHHCHHHHHHHHH	23.45	21454597
3601	Phosphorylation	VQCHHRLSMTDDSKK CCCCHHCCCCCCCCC	21.42	25521595
3603	Phosphorylation	CHHRLSMTDDSKKQD CCHHCCCCCCCCCCC	33.02	25521595
3612	Phosphorylation	DSKKQDLSSSLTDDS CCCCCCCHHCCCCCC	26.60	26060331
3613	Phosphorylation	SKKQDLSSSLTDDSK CCCCCCHHCCCCCCC	36.34	26824392
3614	Phosphorylation	KKQDLSSSLTDDSKN CCCCCHHCCCCCCCC	31.73	25521595
3616	Phosphorylation	QDLSSSLTDDSKNAQ CCCHHCCCCCCCCCC	39.44	18846507
3763	Phosphorylation	AQQSSTRSASHSSAT CCCCCCCCCCCCCCC	33.92	25338131
3768	Phosphorylation	TRSASHSSATTTVLT CCCCCCCCCCCEEEE	24.98	-
3771	Phosphorylation	ASHSSATTTVLTTQQ CCCCCCCCEEEECCH	18.02	-
3772	Phosphorylation	SHSSATTTVLTTQQR CCCCCCCEEEECCHH	14.79	-
3916	Ubiquitination	EQKDDKEKKNHEEKE HCCCHHHHCCHHHHH	65.69	-
3944	Ubiquitination	VVVASGLKSQSKRAM EEEEECCCCCCCHHH	50.39	22790023
3944	Ubiquitination	VVVASGLKSQSKRAM EEEEECCCCCCCHHH	50.39	22790023
3947	Phosphorylation	ASGLKSQSKRAMAST EECCCCCCCHHHHCC	31.06	23140645
3953	Phosphorylation	QSKRAMASTPPRPPS CCCHHHHCCCCCCCC	28.50	25159016
3954	Phosphorylation	SKRAMASTPPRPPSR CCHHHHCCCCCCCCC	27.98	25159016
3960	Phosphorylation	STPPRPPSRRGRTIP CCCCCCCCCCCCCCC	36.97	25159016
3972	Phosphorylation	TIPDKIGSASSSADA CCCCCCCCCCCCHHH	28.57	29514104
3982	Ubiquitination	SSADAASKIITVPVF CCHHHHHHHHHHHHH	33.14	-
4034	Phosphorylation	DLTVKLGSKVITDPS EEEEEECCEEECCCC	33.90	25777480
4038	Phosphorylation	KLGSKVITDPSLSKT EECCEEECCCCCCCC	44.86	25777480
4041	Phosphorylation	SKVITDPSLSKTDSF CEEECCCCCCCCCCC	48.35	25777480
4043	Phosphorylation	VITDPSLSKTDSFKR EECCCCCCCCCCCCC	37.54	25777480
4044	Ubiquitination	ITDPSLSKTDSFKRL ECCCCCCCCCCCCCC	62.74	22790023
4044	Ubiquitination	ITDPSLSKTDSFKRL ECCCCCCCCCCCCCC	62.74	22790023
4045	Phosphorylation	TDPSLSKTDSFKRLH CCCCCCCCCCCCCCC	33.24	26824392
4047	Phosphorylation	PSLSKTDSFKRLHPE CCCCCCCCCCCCCCC	37.59	24453211
4063	Phosphorylation	DHGDLVGSCPEDEAL CCCCCCCCCCCCCCC	21.01	-
4134	Ubiquitination	IASTTQEKPKDSDQF EEECCCCCCCCCCCC	47.77	-
4169	Phosphorylation	AEPPPVKSAVQATSP CCCCCCCCCCCCCCC	33.63	-
4216	Phosphorylation	LRLVLGVTDDGEGSH HHHHHCCCCCCCCCC	26.95	25367039
4222	Phosphorylation	VTDDGEGSHILQSPS CCCCCCCCCCCCCCC	11.76	25367039
4227	Phosphorylation	EGSHILQSPSANVLP CCCCCCCCCCCCCCC	19.85	25367039
4229	Phosphorylation	SHILQSPSANVLPTL CCCCCCCCCCCCCCC	37.41	25367039
4235	Phosphorylation	PSANVLPTLPFHVLR CCCCCCCCCCHHHHH	42.79	25367039
4243	Phosphorylation	LPFHVLRSLFSATPL CCHHHHHHHHCCCCC	29.61	25367039
4246	Phosphorylation	HVLRSLFSATPLTTD HHHHHHHCCCCCCCC	36.20	25367039
4248	Phosphorylation	LRSLFSATPLTTDDG HHHHHCCCCCCCCCC	20.03	25367039
4251	Phosphorylation	LFSATPLTTDDGVLL HHCCCCCCCCCCHHH	29.40	25367039
4252	Phosphorylation	FSATPLTTDDGVLLR HCCCCCCCCCCHHHH	39.51	25367039
4298	Phosphorylation	SQTEPQVSNSHNPTS CCCCCCCCCCCCCCC	27.63	25367039
4300	Phosphorylation	TEPQVSNSHNPTSAE CCCCCCCCCCCCCHH	19.69	25367039
4304	Phosphorylation	VSNSHNPTSAEEQQL CCCCCCCCCHHHHHH	45.98	25367039
4305	Phosphorylation	SNSHNPTSAEEQQLY CCCCCCCCHHHHHHH	34.63	25367039
4312	Phosphorylation	SAEEQQLYWAKGTGF CHHHHHHHEECCCCC	10.05	25367039
4389	Phosphorylation	SVLLELLSQSCLIPA HHHHHHHHCCCCHHH	32.45	23608596
4391	Phosphorylation	LLELLSQSCLIPAMS HHHHHHCCCCHHHHH	13.91	23608596
4484	Acetylation	RSKRENVKAGVKPDA HHHHHHHHCCCCCCC	51.51	2392707
4544	Phosphorylation	VMKPKPLSVLKSLEE CCCCCCHHHHHHHHH	33.65	27149854
4548	Phosphorylation	KPLSVLKSLEEKYVA CCHHHHHHHHHHHHH	36.53	27149854
4618	Phosphorylation	STSLPLSSSSSVFVR HCCCCCCCCCCEEEE	41.75	-
4816	Phosphorylation	KRVGRTMSHHAAALK CCCCCHHHHHHHHHH	16.11	28418008
4850	Phosphorylation	DPDIEDASPVCRATA CCCHHHCCCCHHHCC	30.13	26824392
4862	Phosphorylation	ATAGAEDTLTHDHVN HCCCCCCCCCCCCCC	25.68	21183079
4871	Phosphorylation	THDHVNPSSSKDLPS CCCCCCCCCCCCCCC	41.88	26060331
4872	Phosphorylation	HDHVNPSSSKDLPSD CCCCCCCCCCCCCCC	42.54	26060331
4873	Phosphorylation	DHVNPSSSKDLPSDF CCCCCCCCCCCCCCC	34.23	26060331

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BIRC6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BIRC6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BIRC6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BIRC6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-476; SER-489 ANDSER-2976, AND MASS SPECTROMETRY.
PubMed: 17242355