NKRF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NKRF_MOUSE
• UniProt AC: Q8BY02
• Protein Name: NF-kappa-B-repressing factor
• Gene Name: Nkrf
• Organism: Mus musculus (Mouse).
• Sequence Length: 690
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription (By similarity)..
• Protein Sequence: MEKILHMAEGIDIGEMPSYDLMLPKPSKGQKRYLSTYDGQNPPKKQAGSKFHVRARFEPVHFVASSSKAERQEDPYGPQTKDVNGRTHFASMPRNFYQDYTQDSFSIQDGNSQYCNSSGFIFTKDQPVATNMYFDSGNPAPSSTSQQANCQPAPEPPPSQMYPESLVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHIIGEDLVVCQIGMLSYEFPPALKPPEDLVVLGKDASGQPIFNSSAKHWTNFVITENANDAIGILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKVLQKTQPTYPSVKSSQCHSGSSPKGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKSVKYEAAGEAVKTLKKTQPTVINNLKKGTVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNKIAKRDIEQIIRNYARSESHSDLTFSTELTNDERKQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
421	Phosphorylation	PTYPSVKSSQCHSGS CCCCCCCHHHCCCCC	24.40	27717184
426	Phosphorylation	VKSSQCHSGSSPKGS CCHHHCCCCCCCCCC	48.25	27717184
428	Phosphorylation	SSQCHSGSSPKGSGK HHHCCCCCCCCCCCC	46.62	23684622
429	Phosphorylation	SQCHSGSSPKGSGKK HHCCCCCCCCCCCCC	33.87	27717184
565	Phosphorylation	LLRKMGWTGGGLGKS HHHHHCCCCCCCCCC	21.88	26239621
572	Phosphorylation	TGGGLGKSGEGIREP CCCCCCCCCCCCCCC	40.03	26239621
616	Phosphorylation	IIRNYARSESHSDLT HHHHHHHCCCCCCCE	34.97	30635358
618	Phosphorylation	RNYARSESHSDLTFS HHHHHCCCCCCCEEC	29.54	30635358
620	Phosphorylation	YARSESHSDLTFSTE HHHCCCCCCCEECEE	43.52	30635358
623	Phosphorylation	SESHSDLTFSTELTN CCCCCCCEECEECCH	22.11	30635358
625	Phosphorylation	SHSDLTFSTELTNDE CCCCCEECEECCHHH	18.75	30635358
626	Phosphorylation	HSDLTFSTELTNDER CCCCEECEECCHHHH	30.72	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NKRF_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NKRF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NKRF_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NKRF_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.