NDUAD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUAD_MOUSE
• UniProt AC: Q9ERS2
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
• Gene Name: Ndufa13
• Organism: Mus musculus (Mouse).
• Sequence Length: 144
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side . Nucleus . Localizes mainly in the mitochondrion. May be translocated into the nucleus upon IFN/RA treatment.
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes..
• Protein Sequence: MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMFAVGIGALIFGYWRMMRWNQERRRLLIEDLEARIALMPLFQAEKDRRTLQILRENLEEEAIIMKDVPNWKVGESVFHTTRWVPPLIGEMYGLRTKEEMSNANFGFTWYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASKVKQD ------CCCCCCCCC	22.05	-
7	Acetylation	-MAASKVKQDMPPPG -CCCCCCCCCCCCCC	44.30	23864654
7	Succinylation	-MAASKVKQDMPPPG -CCCCCCCCCCCCCC	44.30	26388266
22	Acetylation	GYGPIDYKRNLPRRG CCCCCCCCCCCCCCC	30.94	24062335
22	Succinylation	GYGPIDYKRNLPRRG CCCCCCCCCCCCCCC	30.94	23954790
99	Acetylation	EEEAIIMKDVPNWKV HHHCEEEECCCCCCC	45.20	23954790
99	Succinylation	EEEAIIMKDVPNWKV HHHCEEEECCCCCCC	45.20	23954790
105	Malonylation	MKDVPNWKVGESVFH EECCCCCCCCCCCCC	47.18	26320211
114	Phosphorylation	GESVFHTTRWVPPLI CCCCCCCCCCCCCHH	17.60	27742792

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUAD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUAD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUAD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUAD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.