STON2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STON2_MOUSE
• UniProt AC: Q8BZ60
• Protein Name: Stonin-2
• Gene Name: Ston2
• Organism: Mus musculus (Mouse).
• Sequence Length: 895
• Subcellular Localization: Cytoplasm. Membrane. Cell junction, synapse, synaptosome. Some fraction is membrane-associated.
• Protein Description: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating (By similarity)..
• Protein Sequence: MTTLDHVIATHQSEWVSFSEEPLFPTPLEGGTEEHFPGLSSSSERSESSSGENHVVDEGSQDLSHSEQDDSSEKMGLISEAASPPGSPVQPTPDLASAISNWVQFEDDTPWSSTSPPHKETALTLTMPCWTCPSFDSLRRCPLTSESSWTTHSEDTSSPSVAPSYTDLQLINTEEQASGRASGTDSTDNSSSLQEDEEVEMEAISWWAGSPAMNGHPAAPPVTTARFPSWVTFEDNEVGCPSPPVPSPKKPNTPSAATAAPDVPFNSTGSFKRDRPKSTLMNLPKVQKLDISSLNRPPSVIEAPPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSVSSTTGKSQRDSLIVVYQDAISFDDSGKSQPHPDAIEKLKQLQIDDPDPVGNTALPDDDPTASVELDAPSPASALSQPRDGWPMMLRIPEKKNIMSSRHWGPIYIKLTASGYLQLYYEQGLEKPFREFKLEICHEVSEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHAAEREQVIKLGTTNYDDFRSFIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGTVGKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILIKGNEIVSRQDIMPTTTTKWIKLHECRFHGCVDEDVFNSSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASINGAEVEVQSWLRMSPGFSSNRDPLTQVPCENVMVRYPVPSEWVKNFRRDSVLGEKSLKAKVNRGASFGSAGASGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANYVNVEFSMPTTSASKAAVRSVSVEDKPDVRKWVNYSAHYSYKVEIEQKKSLKPDFEGEDLENPKECGVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
137	Phosphorylation	WTCPSFDSLRRCPLT CCCCCHHHHCCCCCC	23.05	23140645
181	Ubiquitination	EEQASGRASGTDSTD CHHHCCCCCCCCCCC	18.81	27667366
242	Phosphorylation	DNEVGCPSPPVPSPK CCCCCCCCCCCCCCC	46.01	30352176
247	Phosphorylation	CPSPPVPSPKKPNTP CCCCCCCCCCCCCCC	49.97	25195567
253	Phosphorylation	PSPKKPNTPSAATAA CCCCCCCCCCCCCCC	27.44	25266776
255	Ubiquitination	PKKPNTPSAATAAPD CCCCCCCCCCCCCCC	28.62	27667366
255	Phosphorylation	PKKPNTPSAATAAPD CCCCCCCCCCCCCCC	28.62	22210690
258	Phosphorylation	PNTPSAATAAPDVPF CCCCCCCCCCCCCCC	24.06	23375375
262	Ubiquitination	SAATAAPDVPFNSTG CCCCCCCCCCCCCCC	56.87	27667366
267	Phosphorylation	APDVPFNSTGSFKRD CCCCCCCCCCCCCCC	34.23	22324799
268	Phosphorylation	PDVPFNSTGSFKRDR CCCCCCCCCCCCCCC	37.64	25266776
270	Phosphorylation	VPFNSTGSFKRDRPK CCCCCCCCCCCCCCC	27.90	25521595
278	Phosphorylation	FKRDRPKSTLMNLPK CCCCCCCCCCCCCCC	29.47	25266776
279	Phosphorylation	KRDRPKSTLMNLPKV CCCCCCCCCCCCCCC	35.83	29472430
293	Phosphorylation	VQKLDISSLNRPPSV CEECCHHHCCCCCCH	29.96	26239621
299	Phosphorylation	SSLNRPPSVIEAPPW HHCCCCCCHHCCCCC	38.11	21082442
355	Phosphorylation	TGKSQRDSLIVVYQD CCCCCCCEEEEEEEE	23.37	29899451
381	Ubiquitination	PHPDAIEKLKQLQID CCHHHHHHHHHCCCC	55.67	27667366
416	Phosphorylation	LDAPSPASALSQPRD ECCCCCHHHHCCCCC	32.88	29899451
495	Phosphorylation	DENGRIHSLRIDRVT CCCCCEEEEEEEEEE	19.57	24719451
634	Phosphorylation	DIMPTTTTKWIKLHE CCCCCCCCCEEEEEE	23.45	28576409
743	Phosphorylation	VKNFRRDSVLGEKSL HHHHCCCCCCCCHHH	19.89	-
749	Phosphorylation	DSVLGEKSLKAKVNR CCCCCCHHHHHHHCC	30.69	22871156
759	Phosphorylation	AKVNRGASFGSAGAS HHHCCCCCCCCCCCC	32.72	22324799
762	Phosphorylation	NRGASFGSAGASGSE CCCCCCCCCCCCCCC	22.86	22324799

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STON2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STON2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STON2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STON2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.