dbPTM

FAS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FAS_MOUSE
UniProt AC	P19096
Protein Name	Fatty acid synthase
Gene Name	Fasn
Organism	Mus musculus (Mouse).
Sequence Length	2504
Subcellular Localization	Cytoplasm. Melanosome.
Protein Description	Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein..
Protein Sequence	MEEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGLYGLPKRSGKLKDLSKFDASFFGVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRGTNTGVWVGVSGSEASEALSRDPETLLGYSMVGCQRAMMANRLSFFFDFKGPSIALDTACSSSLLALQNAYQAIRSGECPAALVGGINLLLKPNTSVQFMKLGMLSPDGTCRSFDDSGSGYCRSEAVVAVLLTKKSLARRVYATILNAGTNTDGSKEQGVTFPSGEVQEQLICSLYQPAGLAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQAPLLIGSTKSNMGHPEPASGLAALTKVLLSLEHGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGNVGINSFGFGGSNVHVILQPNTRQAPAPTAHAALPHLLHASGRTLEAVQDLLEQGRQHSQDLAFVSMLNDIAATPTAAMPFRGYTVLGVEGRVQEVQQVSTNKRPLWFICSGMGTQWRGMGLSLMRLDSFRESILRSDEAVKPLGVKVSDLLLSTDERTFDDIVHAFVSLTAIQIALIDLLTSVGLKPDGIIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDAHLPPGSMAAVGLSWEECKQRCPAGVVPACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAFHSYFMEGIAPTLLQALKKVIREPRPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLVSPVLFQEALWHIPEHAVVLEIAPHALLQAVLKRGVKSSCTIIPLMKRDHKDNLEFFLTNLGKVHLTGINVNPNALFPPVEFPAPRGTPLISPHIKWDHSQTWDVPVAEDFPNGSSSSSATVYSIDASPESPDHYLVDHCIDGRVIFPGTGYLCLVWKTLARSLGLSLEETPVVFENVSFHQATILPKTGTVALEVRLLEASHAFEVSDTGNLIVSGKVYLWEDPNSKLFDHPEVPTPPESASVSRLTQGEVYKELRLRGYDYGPQFQGICEATLEGEQGKLLWKDNWVTFMDTMLQVSILGSSQQSLQLPTRVTAIYIDPATHRQKVYRLKEDTQVADVTTSRCLGITVSGGIHISRLQTTATSRRQQEQLVPTLEKFVFTPHMEAECLSESTALQKELQLCKGLARALQTKATQQGLKAAMLGQEDPPQHGLPRLLAAACQLQLNGNLQLELGEALAQERLLLPEDPLISGLLNSQALKACVDTALENLSTLKMKVAEVLAGEGHLYSRIPALLNTQPMLQLEYTATDRHPQALKDVQTKLQQHDVAQGQWNPSDPAPSSLGALDLLVCNCALATLGDPALALDNMVAALKEGGFLLVHTVLKGHALGETLACLPSEVQPAPSLLSQEEWESLFSRKALHLVGLKRSFYGTALFLCRRAIPQEKPIFLSVEDTSFQWVDSLKSTLATSSSQPVWLTAMDCPTSGVVGLVNCLRKEPGGHRIRCILLSNLSNTSHAPKLDPGSPELQQVLKHDLVMNVYRDGAWGAFRHFQLEQDKPKEQTAHAFVNVLTRGDLASIRWVSSPLKHTQPSSSGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLGMEFSGRDRCGRRVMGLVPAEGLATSVLLSSDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRIQRGETVLIHSGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQHVLLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVTFHGILLDALFEEANDSWREVAALLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHIGKVLVQVREEEPEAVLPGAQPTLISAISKTFCPAHKSYIITGGLGGFGLELARWLVLRGAQRLVLTSRSGIRTGYQAKHIREWRRQGIQVLVSTSNVSSLEGARALIAEATKLGPVGGVFNLAMVLRDAMLENQTPELFQDVNKPKYNGTLNLDRATREACPELDYFVAFSSVSCGRGNAGQTNYGFANSTMERICEQRRHDGLPGLAVQWGAIGDVGIVLEAMGTNDTVIGGTLPQRISSCMEVLDLFLNQPHAVLSSFVLAEKKAVAHGDGDTQRDLVKAVAHILGIRDLAGINLDSTLADLGLDSLMGVEVRQILEREHDLVLPMREVRQLTLRKLQEMSSKTDSATDTTAPKSRSDTSLKQNQLNLSTLLVNPEGPTLTQLNSVQSSERPLFLVHPIEGSTTVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQVQPEGPYRIAGYSFGACVAFEMCSQLQAQQGPAPTHNNLFLFDGSHTYVLAYTQSYRAKMTPGCEAEAEAEALCFFIKQFLDVEHSKVLEALLPLKSLEDRVAASVDLITKSHHSLDRRELSFAAVSFYHKLRAADQYKPKAKYHGNVTLLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDHRTLLEGSGLESIINIIHSSLAEPRVSVREG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEEVVIAG -------CCEEEEEC	43.05	-
41	Ubiquitination	TDDDRRWKAGLYGLP CCCHHHHHHHHCCCC	30.66	22790023
49	Acetylation	AGLYGLPKRSGKLKD HHHCCCCCCCCCCCC	65.32	7609155
49	Malonylation	AGLYGLPKRSGKLKD HHHCCCCCCCCCCCC	65.32	26320211
59	Acetylation	GKLKDLSKFDASFFG CCCCCHHHCCHHHHC	55.34	23806337
59	Ubiquitination	GKLKDLSKFDASFFG CCCCCHHHCCHHHHC	55.34	22790023
63	Phosphorylation	DLSKFDASFFGVHPK CHHHCCHHHHCCCHH	23.97	27180971
70	Acetylation	SFFGVHPKQAHTMDP HHHCCCHHHCCCCCH	45.28	22826441
70	Malonylation	SFFGVHPKQAHTMDP HHHCCCHHHCCCCCH	45.28	26320211
70	Ubiquitination	SFFGVHPKQAHTMDP HHHCCCHHHCCCCCH	45.28	-
135	Glutathionylation	LGYSMVGCQRAMMAN HHHHHHHHHHHHHHH	1.36	24333276
135	S-palmitoylation	LGYSMVGCQRAMMAN HHHHHHHHHHHHHHH	1.36	28526873
161	S-palmitoylation	SIALDTACSSSLLAL CCHHHHHHHHHHHHH	4.38	28526873
180	S-palmitoylation	QAIRSGECPAALVGG HHHHCCCCCHHEEEH	2.95	28680068
193	Ubiquitination	GGINLLLKPNTSVQF EHEEEEECCCCCCEE	35.87	22790023
202	Acetylation	NTSVQFMKLGMLSPD CCCCEEEECCCCCCC	43.08	23236377
205	Oxidation	VQFMKLGMLSPDGTC CEEEECCCCCCCCCC	4.92	17242355
207	Phosphorylation	FMKLGMLSPDGTCRS EEECCCCCCCCCCCC	16.44	25521595
211	Phosphorylation	GMLSPDGTCRSFDDS CCCCCCCCCCCCCCC	16.48	26745281
212	Glutathionylation	MLSPDGTCRSFDDSG CCCCCCCCCCCCCCC	4.14	24333276
212	S-palmitoylation	MLSPDGTCRSFDDSG CCCCCCCCCCCCCCC	4.14	28526873
220	Phosphorylation	RSFDDSGSGYCRSEA CCCCCCCCCCCCHHH	30.46	23684622
223	S-palmitoylation	DDSGSGYCRSEAVVA CCCCCCCCCHHHHHH	4.38	28526873
225	Phosphorylation	SGSGYCRSEAVVAVL CCCCCCCHHHHHHHH	26.75	24719451
237	Phosphorylation	AVLLTKKSLARRVYA HHHHCCHHHHHHHHH	28.90	24719451
253	Phosphorylation	ILNAGTNTDGSKEQG HHCCCCCCCCCCCCC	41.39	26525534
286	Phosphorylation	PAGLAPESLEYIEAH CCCCCHHHHHHHHHH	25.99	30352176
298	Acetylation	EAHGTGTKVGDPQEL HHHCCCCCCCCHHHH	45.63	-
313	Glutathionylation	NGITRSLCAFRQAPL CCHHHHHHHHHCCCE	3.38	24333276
326	Ubiquitination	PLLIGSTKSNMGHPE CEEEECCCCCCCCCC	41.34	22790023
336	Phosphorylation	MGHPEPASGLAALTK CCCCCCCCHHHHHHH	45.08	20469934
342	Phosphorylation	ASGLAALTKVLLSLE CCHHHHHHHHHHHHH	17.87	20469934
445	Phosphorylation	LEQGRQHSQDLAFVS HHHHHHHHHHHHHHH	19.63	27180971
460	Phosphorylation	MLNDIAATPTAAMPF HHHHHCCCCCCCCCC	16.49	27180971
486	Phosphorylation	VQEVQQVSTNKRPLW EEEEEEECCCCCEEE	23.17	30352176
487	Phosphorylation	QEVQQVSTNKRPLWF EEEEEECCCCCEEEE	46.00	30352176
489	Acetylation	VQQVSTNKRPLWFIC EEEECCCCCEEEEEE	56.32	7611609
496	S-palmitoylation	KRPLWFICSGMGTQW CCEEEEEECCCCCCC	1.78	28526873
509	Phosphorylation	QWRGMGLSLMRLDSF CCCCCCHHHEEHHHH	17.87	27180971
515	Phosphorylation	LSLMRLDSFRESILR HHHEEHHHHHHHHHC	30.69	22817900
528	Acetylation	LRSDEAVKPLGVKVS HCCCCCCCCCCCCHH	41.39	23806337
528	Malonylation	LRSDEAVKPLGVKVS HCCCCCCCCCCCCHH	41.39	26320211
528	Ubiquitination	LRSDEAVKPLGVKVS HCCCCCCCCCCCCHH	41.39	27667366
533	Ubiquitination	AVKPLGVKVSDLLLS CCCCCCCCHHHHHHC	33.93	22790023
535	Phosphorylation	KPLGVKVSDLLLSTD CCCCCCHHHHHHCCC	19.47	24899341
540	Phosphorylation	KVSDLLLSTDERTFD CHHHHHHCCCCCCHH	33.51	26525534
673	Acetylation	KQEGVFAKEVRTGGL HHCCCCEEECCCCCC	45.32	22826441
673	Malonylation	KQEGVFAKEVRTGGL HHCCCCEEECCCCCC	45.32	26320211
673	Succinylation	KQEGVFAKEVRTGGL HHCCCCEEECCCCCC	45.32	-
673	Ubiquitination	KQEGVFAKEVRTGGL HHCCCCEEECCCCCC	45.32	27667366
724	Phosphorylation	IPEAQWQSSLARTSS CCHHHHHHHHHCCCC	25.10	21082442
725	Phosphorylation	PEAQWQSSLARTSSA CHHHHHHHHHCCCCC	15.79	21082442
776	Acetylation	AVLKRGVKSSCTIIP HHHHHCCCCCCEEEE	39.20	23806337
776	Ubiquitination	AVLKRGVKSSCTIIP HHHHHCCCCCCEEEE	39.20	22790023
777	Phosphorylation	VLKRGVKSSCTIIPL HHHHCCCCCCEEEEC	28.39	22817900
778	Phosphorylation	LKRGVKSSCTIIPLM HHHCCCCCCEEEECC	15.01	22817900
779	S-palmitoylation	KRGVKSSCTIIPLMK HHCCCCCCEEEECCC	4.01	28526873
780	Phosphorylation	RGVKSSCTIIPLMKR HCCCCCCEEEECCCC	24.72	29472430
786	Acetylation	CTIIPLMKRDHKDNL CEEEECCCCCCCCCC	63.46	23864654
786	Malonylation	CTIIPLMKRDHKDNL CEEEECCCCCCCCCC	63.46	26320211
786	Ubiquitination	CTIIPLMKRDHKDNL CEEEECCCCCCCCCC	63.46	-
790	Acetylation	PLMKRDHKDNLEFFL ECCCCCCCCCCHHHH	53.23	23806337
790	Ubiquitination	PLMKRDHKDNLEFFL ECCCCCCCCCCHHHH	53.23	22790023
893	S-nitrosocysteine	FPGTGYLCLVWKTLA CCCCCHHHHHHHHHH	1.85	-
893	S-nitrosylation	FPGTGYLCLVWKTLA CCCCCHHHHHHHHHH	1.85	20925432
930	Phosphorylation	TILPKTGTVALEVRL EECCCCCCEEEEEEE	14.08	27180971
967	Acetylation	LWEDPNSKLFDHPEV EEECCCCCCCCCCCC	60.87	23236377
967	Ubiquitination	LWEDPNSKLFDHPEV EEECCCCCCCCCCCC	60.87	22790023
976	Phosphorylation	FDHPEVPTPPESASV CCCCCCCCCCCCCCC	57.56	22942356
980	Phosphorylation	EVPTPPESASVSRLT CCCCCCCCCCCCCCC	31.45	27180971
982	Phosphorylation	PTPPESASVSRLTQG CCCCCCCCCCCCCCC	29.88	27180971
993	Acetylation	LTQGEVYKELRLRGY CCCCCHHHHHHHCCC	56.29	23806337
993	Malonylation	LTQGEVYKELRLRGY CCCCCHHHHHHHCCC	56.29	26320211
993	Ubiquitination	LTQGEVYKELRLRGY CCCCCHHHHHHHCCC	56.29	27667366
1020	Ubiquitination	TLEGEQGKLLWKDNW EEECCCCCEEEECCC	39.85	22790023
1029	Phosphorylation	LWKDNWVTFMDTMLQ EEECCCCHHHHHHHH	12.59	-
1033	Phosphorylation	NWVTFMDTMLQVSIL CCCHHHHHHHHHHHH	14.16	-
1057	Phosphorylation	PTRVTAIYIDPATHR CCEEEEEEECCCCCH	9.23	25367039
1071	Acetylation	RQKVYRLKEDTQVAD HHHEEECCCCCCCCC	44.54	23806337
1071	Malonylation	RQKVYRLKEDTQVAD HHHEEECCCCCCCCC	44.54	26320211
1071	Ubiquitination	RQKVYRLKEDTQVAD HHHEEECCCCCCCCC	44.54	27667366
1100	Phosphorylation	IHISRLQTTATSRRQ EEEEECCCCCCCHHH	24.00	23737553
1101	Phosphorylation	HISRLQTTATSRRQQ EEEECCCCCCCHHHH	18.25	23737553
1103	Phosphorylation	SRLQTTATSRRQQEQ EECCCCCCCHHHHHH	22.22	23737553
1104	Phosphorylation	RLQTTATSRRQQEQL ECCCCCCCHHHHHHH	24.01	23737553
1114	Phosphorylation	QQEQLVPTLEKFVFT HHHHHHCHHHHHHCC	39.82	22817900
1117	Ubiquitination	QLVPTLEKFVFTPHM HHHCHHHHHHCCHHH	50.36	22790023
1128	S-palmitoylation	TPHMEAECLSESTAL CHHHHHHHCCCCHHH	6.98	28526873
1133	Phosphorylation	AECLSESTALQKELQ HHHCCCCHHHHHHHH	27.60	30352176
1137	Ubiquitination	SESTALQKELQLCKG CCCHHHHHHHHHHHH	62.33	22790023
1143	Acetylation	QKELQLCKGLARALQ HHHHHHHHHHHHHHH	66.60	22826441
1143	Malonylation	QKELQLCKGLARALQ HHHHHHHHHHHHHHH	66.60	26320211
1143	Ubiquitination	QKELQLCKGLARALQ HHHHHHHHHHHHHHH	66.60	-
1152	Malonylation	LARALQTKATQQGLK HHHHHHHHHHHHHHH	36.15	26320211
1152	Ubiquitination	LARALQTKATQQGLK HHHHHHHHHHHHHHH	36.15	27667366
1159	Malonylation	KATQQGLKAAMLGQE HHHHHHHHHHHCCCC	40.71	26320211
1159	Ubiquitination	KATQQGLKAAMLGQE HHHHHHHHHHHCCCC	40.71	27667366
1216	Phosphorylation	LISGLLNSQALKACV HHHHHCCHHHHHHHH	19.46	23984901
1222	S-palmitoylation	NSQALKACVDTALEN CHHHHHHHHHHHHHH	2.45	28526873
1234	Acetylation	LENLSTLKMKVAEVL HHHHHHHHHHHHHHH	36.44	22826441
1234	Ubiquitination	LENLSTLKMKVAEVL HHHHHHHHHHHHHHH	36.44	22790023
1236	Acetylation	NLSTLKMKVAEVLAG HHHHHHHHHHHHHCC	36.38	22826441
1236	Ubiquitination	NLSTLKMKVAEVLAG HHHHHHHHHHHHHCC	36.38	22790023
1248	Phosphorylation	LAGEGHLYSRIPALL HCCCCCHHHCHHHHH	7.10	22817900
1249	Phosphorylation	AGEGHLYSRIPALLN CCCCCHHHCHHHHHC	30.05	24899341
1276	Acetylation	DRHPQALKDVQTKLQ CCCHHHHHHHHHHHH	59.89	23806337
1276	Malonylation	DRHPQALKDVQTKLQ CCCHHHHHHHHHHHH	59.89	26320211
1276	Ubiquitination	DRHPQALKDVQTKLQ CCCHHHHHHHHHHHH	59.89	27667366
1354	S-palmitoylation	ALGETLACLPSEVQP HHCCCCCCCCCCCCC	6.89	28526873
1378	Ubiquitination	WESLFSRKALHLVGL HHHHHHHHHHHHHCC	54.85	22790023
1397	S-palmitoylation	YGTALFLCRRAIPQE HHHHHHHHHCCCCCC	1.85	28526873
1405	Acetylation	RRAIPQEKPIFLSVE HCCCCCCCCEEEEEE	37.86	23954790
1424	Phosphorylation	QWVDSLKSTLATSSS CHHHHHHHHHCCCCC	33.67	26643407
1425	Phosphorylation	WVDSLKSTLATSSSQ HHHHHHHHHCCCCCC	20.87	26643407
1428	Phosphorylation	SLKSTLATSSSQPVW HHHHHHCCCCCCCEE	32.05	26643407
1429	Phosphorylation	LKSTLATSSSQPVWL HHHHHCCCCCCCEEE	23.53	26643407
1430	Phosphorylation	KSTLATSSSQPVWLT HHHHCCCCCCCEEEE	28.74	26643407
1431	Phosphorylation	STLATSSSQPVWLTA HHHCCCCCCCEEEEE	37.97	26643407
1441	S-palmitoylation	VWLTAMDCPTSGVVG EEEEEECCCCCCCHH	2.25	28526873
1452	S-palmitoylation	GVVGLVNCLRKEPGG CCHHHHHHHHCCCCC	2.79	28526873
1464	S-nitrosylation	PGGHRIRCILLSNLS CCCCEEEEEEEECCC	2.09	23748021
1478	Ubiquitination	SNTSHAPKLDPGSPE CCCCCCCCCCCCCHH	67.32	22790023
1483	Phosphorylation	APKLDPGSPELQQVL CCCCCCCCHHHHHHH	22.16	28066266
1491	Acetylation	PELQQVLKHDLVMNV HHHHHHHHHCCEEEE	35.89	23201123
1491	Ubiquitination	PELQQVLKHDLVMNV HHHHHHHHHCCEEEE	35.89	22790023
1499	Phosphorylation	HDLVMNVYRDGAWGA HCCEEEEECCCCCHH	9.66	22817900
1516	Acetylation	HFQLEQDKPKEQTAH HEECCCCCCHHHHHH	58.65	22826441
1518	Acetylation	QLEQDKPKEQTAHAF ECCCCCCHHHHHHHH	69.10	22826441
1541	Phosphorylation	LASIRWVSSPLKHTQ HHHEEEECCCCCCCC	21.19	28066266
1542	Phosphorylation	ASIRWVSSPLKHTQP HHEEEECCCCCCCCC	25.32	28066266
1557	S-nitrosylation	SSSGAQLCTVYYASL CCCHHHEEEEEEEEC	1.28	24895380
1573	Phosphorylation	FRDIMLATGKLSPDA HHHHHHHCCCCCCCC	30.78	23984901
1575	Acetylation	DIMLATGKLSPDAIP HHHHHCCCCCCCCCC	41.24	22826441
1575	Malonylation	DIMLATGKLSPDAIP HHHHHCCCCCCCCCC	41.24	26320211
1575	Ubiquitination	DIMLATGKLSPDAIP HHHHHCCCCCCCCCC	41.24	27667366
1577	Phosphorylation	MLATGKLSPDAIPGK HHHCCCCCCCCCCCC	24.99	25521595
1584	Acetylation	SPDAIPGKWASRDCM CCCCCCCCCCCCCCC	33.94	22826441
1584	Ubiquitination	SPDAIPGKWASRDCM CCCCCCCCCCCCCCC	33.94	22790023
1587	Phosphorylation	AIPGKWASRDCMLGM CCCCCCCCCCCCCCC	27.77	22817900
1697	N6-(pyridoxal phosphate)lysine	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	-
1697	Acetylation	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	23806337
1697	Malonylation	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	26320211
1697	Other	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	-
1697	Ubiquitination	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	27667366
1719	Phosphorylation	SFANSRDTSFEQHVL CCCCCCCCCHHHEEE	33.92	28066266
1720	Phosphorylation	FANSRDTSFEQHVLL CCCCCCCCHHHEEEE	30.95	26824392
1745	Acetylation	LNSLAEEKLQASVRC HHHHHHHHHHHHHHH	37.09	23236377
1745	Ubiquitination	LNSLAEEKLQASVRC HHHHHHHHHHHHHHH	37.09	22790023
1764	Acetylation	GRFLEIGKFDLSNNH CCEEEEEEEECCCCC	41.17	23954790
1817	Ubiquitination	GIRDGVVKPLKCTVF CCCCCCCCCCCCEEC	42.07	22790023
1820	Ubiquitination	DGVVKPLKCTVFPKA CCCCCCCCCEECCHH	36.07	22790023
1826	Acetylation	LKCTVFPKAQVEDAF CCCEECCHHHHHHHH	39.73	23236377
1826	Malonylation	LKCTVFPKAQVEDAF CCCEECCHHHHHHHH	39.73	25418362
1826	Ubiquitination	LKCTVFPKAQVEDAF CCCEECCHHHHHHHH	39.73	-
1840	Acetylation	FRYMAQGKHIGKVLV HHHHHCCCCCEEEEE	21.70	23806337
1840	Malonylation	FRYMAQGKHIGKVLV HHHHHCCCCCEEEEE	21.70	26320211
1840	Ubiquitination	FRYMAQGKHIGKVLV HHHHHCCCCCEEEEE	21.70	27667366
1867	Phosphorylation	GAQPTLISAISKTFC CCCCCHHHHHHHCCC	23.74	27180971
1870	Phosphorylation	PTLISAISKTFCPAH CCHHHHHHHCCCCCC	25.92	30352176
1871	Ubiquitination	TLISAISKTFCPAHK CHHHHHHHCCCCCCC	39.24	22790023
1908	Phosphorylation	GAQRLVLTSRSGIRT CCCEEEEEECCCCCC	18.02	22871156
1909	Phosphorylation	AQRLVLTSRSGIRTG CCEEEEEECCCCCCC	21.93	21183079
1911	Phosphorylation	RLVLTSRSGIRTGYQ EEEEEECCCCCCCCH	38.04	29514104
1917	Phosphorylation	RSGIRTGYQAKHIRE CCCCCCCCHHHHHHH	12.51	-
1986	Acetylation	ELFQDVNKPKYNGTL HHHHCCCCCCCCCCC	42.61	23954790
1986	Ubiquitination	ELFQDVNKPKYNGTL HHHHCCCCCCCCCCC	42.61	22790023
1988	Acetylation	FQDVNKPKYNGTLNL HHCCCCCCCCCCCCC	53.62	70257
1988	Ubiquitination	FQDVNKPKYNGTLNL HHCCCCCCCCCCCCC	53.62	22790023
2003	S-nitrosylation	DRATREACPELDYFV CHHHHHHCCCCCEEE	2.00	24895380
2017	S-nitrosylation	VAFSSVSCGRGNAGQ EEEEECCCCCCCCCC	3.95	24895380
2017	S-palmitoylation	VAFSSVSCGRGNAGQ EEEEECCCCCCCCCC	3.95	28680068
2025	Phosphorylation	GRGNAGQTNYGFANS CCCCCCCCCCCCCCH	29.50	25168779
2027	Phosphorylation	GNAGQTNYGFANSTM CCCCCCCCCCCCHHH	19.60	25168779
2032	Phosphorylation	TNYGFANSTMERICE CCCCCCCHHHHHHHH	26.21	25168779
2033	Phosphorylation	NYGFANSTMERICEQ CCCCCCHHHHHHHHH	23.90	25168779
2084	S-nitrosylation	LPQRISSCMEVLDLF HHHHHHHHHHHHHHH	1.84	-
2123	Ubiquitination	DTQRDLVKAVAHILG HHHHHHHHHHHHHHC	44.43	22790023
2141	Phosphorylation	LAGINLDSTLADLGL HCCCCCCHHHHHCCH	28.61	23649490
2142	Phosphorylation	AGINLDSTLADLGLD CCCCCCHHHHHCCHH	26.15	23649490
2150	O-(pantetheine 4'-phosphoryl)serine	LADLGLDSLMGVEVR HHHCCHHHHCCHHHH	25.87	-
2150	Phosphorylation	LADLGLDSLMGVEVR HHHCCHHHHCCHHHH	25.87	23649490
2185	Phosphorylation	LRKLQEMSSKTDSAT HHHHHHHHHCCCCCC	28.12	23984901
2186	Phosphorylation	RKLQEMSSKTDSATD HHHHHHHHCCCCCCC	37.96	23984901
2187	Ubiquitination	KLQEMSSKTDSATDT HHHHHHHCCCCCCCC	49.39	22790023
2188	Phosphorylation	LQEMSSKTDSATDTT HHHHHHCCCCCCCCC	36.81	23984901
2190	Phosphorylation	EMSSKTDSATDTTAP HHHHCCCCCCCCCCC	38.00	24899341
2192	Phosphorylation	SSKTDSATDTTAPKS HHCCCCCCCCCCCCC	37.52	23984901
2194	Phosphorylation	KTDSATDTTAPKSRS CCCCCCCCCCCCCCC	22.09	23984901
2195	Phosphorylation	TDSATDTTAPKSRSD CCCCCCCCCCCCCCC	43.71	23984901
2198	Ubiquitination	ATDTTAPKSRSDTSL CCCCCCCCCCCCCCC	56.91	22790023
2199	Phosphorylation	TDTTAPKSRSDTSLK CCCCCCCCCCCCCCC	35.64	25521595
2201	Phosphorylation	TTAPKSRSDTSLKQN CCCCCCCCCCCCCCC	52.94	25521595
2203	Phosphorylation	APKSRSDTSLKQNQL CCCCCCCCCCCCCCC	36.89	25619855
2204	Phosphorylation	PKSRSDTSLKQNQLN CCCCCCCCCCCCCCC	38.26	25619855
2229	Phosphorylation	PTLTQLNSVQSSERP CCCHHCCCCCCCCCC	30.08	-
2352	Glutathionylation	RAKMTPGCEAEAEAE HCCCCCCCHHHHHHH	4.76	24333276
2352	S-palmitoylation	RAKMTPGCEAEAEAE HCCCCCCCHHHHHHH	4.76	28680068
2374	Phosphorylation	QFLDVEHSKVLEALL HHCCCCHHHHHHHHH	15.79	27180971
2375	Acetylation	FLDVEHSKVLEALLP HCCCCHHHHHHHHHC	53.39	23236377
2375	Ubiquitination	FLDVEHSKVLEALLP HCCCCHHHHHHHHHC	53.39	22790023
2384	Acetylation	LEALLPLKSLEDRVA HHHHHCCCCHHHHHH	51.56	23806337
2384	Ubiquitination	LEALLPLKSLEDRVA HHHHHCCCCHHHHHH	51.56	22790023
2398	Phosphorylation	AASVDLITKSHHSLD HHHHHHHHCCCCCCC	33.52	22817900
2403	Phosphorylation	LITKSHHSLDRRELS HHHCCCCCCCHHHCH	26.92	25266776
2419	Acetylation	AAVSFYHKLRAADQY HHHHHHHHHHHHHHC	28.43	23236377
2427	Acetylation	LRAADQYKPKAKYHG HHHHHHCCCCCEEEC	34.12	23201123
2427	Malonylation	LRAADQYKPKAKYHG HHHHHHCCCCCEEEC	34.12	26320211
2427	Succinylation	LRAADQYKPKAKYHG HHHHHHCCCCCEEEC	34.12	23954790
2427	Ubiquitination	LRAADQYKPKAKYHG HHHHHHCCCCCEEEC	34.12	27667366
2429	Acetylation	AADQYKPKAKYHGNV HHHHCCCCCEEECCE	54.05	23201123
2431	Acetylation	DQYKPKAKYHGNVTL HHCCCCCEEECCEEE	43.86	22826441
2431	Malonylation	DQYKPKAKYHGNVTL HHCCCCCEEECCEEE	43.86	26320211
2431	Ubiquitination	DQYKPKAKYHGNVTL HHCCCCCEEECCEEE	43.86	-
2437	Phosphorylation	AKYHGNVTLLRAKTG CEEECCEEEEEEECC	24.87	22817900
2442	Ubiquitination	NVTLLRAKTGGTYGE CEEEEEEECCCCCCC	41.07	22790023
2443	Phosphorylation	VTLLRAKTGGTYGED EEEEEEECCCCCCCC	39.60	22817900
2446	Phosphorylation	LRAKTGGTYGEDLGA EEEECCCCCCCCCCC	29.69	21082442
2461	S-palmitoylation	DYNLSQVCDGKVSVH CCCHHHHCCCEEEEE	4.41	28526873
2476	Phosphorylation	IIEGDHRTLLEGSGL EEECCCCEECCCCCH	32.07	23984901
2481	Phosphorylation	HRTLLEGSGLESIIN CCEECCCCCHHHHHH	30.72	27180971
2485	Phosphorylation	LEGSGLESIINIIHS CCCCCHHHHHHHHHH	33.54	23984901
2492	Phosphorylation	SIINIIHSSLAEPRV HHHHHHHHHCCCCCC	19.35	23984901
2493	Phosphorylation	IINIIHSSLAEPRVS HHHHHHHHCCCCCCC	19.89	23984901
2500	Phosphorylation	SLAEPRVSVREG--- HCCCCCCCCCCC---	19.41	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1029	T	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
1033	T	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
1464	C	S-nitrosylation	-
S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1464 or Cys-2084 is important for the enzyme dimerization.
2084	C	S-nitrosylation	-
S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1464 or Cys-2084 is important for the enzyme dimerization.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FAS_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RFWD2_MOUSE	Rfwd2	physical	23269672

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FAS_MOUSE

Related Literatures of Post-Translational Modification

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