| UniProt ID | WASC4_MOUSE | |
|---|---|---|
| UniProt AC | Q3UMB9 | |
| Protein Name | WASH complex subunit 4 {ECO:0000312|MGI:MGI:2441787} | |
| Gene Name | Washc4 {ECO:0000312|MGI:MGI:2441787} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1173 | |
| Subcellular Localization | Early endosome . | |
| Protein Description | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. [PubMed: 19922875] | |
| Protein Sequence | MAVDTLSPDWDFDRVDDGSQKIHAEVQLKNYGRFLEEYTSQLRRIEDALDDLIGDVWDFNLDPIALKLLPYEQSSLLELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLFYGEGATDSSMVEGDCQIQMGRFVSFLQELSCFVTRCYEVVMNVIHQLAALYISNKIGPKIIETTGVHFQTMYEHLGELLTVLLTLDEIVDNHVTLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQLLDGMIFQACIEQQFDSLNGGISVSKNSTFAEEFAHSIRSIFANVEAKLGEPSEIDQRDKYVGICGLFVLHFQIFRTVDKKFYKSLLDICKKVPAITLTANIIWFPDNFLIHKMPAAAKLLDRKSLQAIKIHRDTFLQQKAQSLNKDVQSYYVFVSSWMMKMESMLSKEQRMDTFAEDLTNRCNVFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLIELLKAIEHMFYRRSMVVADSVSHITQHLQHQALSSISVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKQRRLIVSLALSVGTQMKTFKDEELFPLQVVMKKLDLISELRERVQAQCDCCFLYWHRAVFPIYLDDVYENAVDAARLHYMFSALRDCVPAMMHSRHLESHELLLDCYDKEIMDILNEHLLDKLCKEIEKDLRLSVHTHLKLDDRNPFKVGRKDLALFFSLNPIRFFNRFIDIRAYVTHYLDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHIFVSRYLYNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLKKKFYIFSQFMYDEHIKSRLIKDIRFFREIKDQNDHKYPFDRAEKFNRGIRKLGITPEGQSYLDQFRQLISQIGNAMGYIRMIRSGGLHCSSNAIRFVPDLEDIVSFEELVKEEGLAEETLRAARHLDSVLSDHTRNSAEGTEYFKMLVDVFAPEFRRPKNIHLRNFYIIVPPLTLNFVEHSISCKEKLNKKNKLGAAFTDDGFAMGVAYTLKLLDQYQEFDSLHWFQSVREKYIKEIRAVAKQQNVQSTSQDEKLLQTMNLTQKRLEVYLQEFELLYFSLSSARIFFRADKTAAEENQEKKEKEEETKTSNGDGPESTVSADPVVK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAVDTLSPD ------CCCCCCCCC | - | ||
| 5 | Phosphorylation | ---MAVDTLSPDWDF ---CCCCCCCCCCCC | 20415495 | ||
| 7 | Phosphorylation | -MAVDTLSPDWDFDR -CCCCCCCCCCCCCC | 22817900 | ||
| 19 | O-linked_Glycosylation | FDRVDDGSQKIHAEV CCCCCCCCCEEEEEE | 55412385 | ||
| 289 | Ubiquitination | STFAEEFAHSIRSIF CHHHHHHHHHHHHHH | 27667366 | ||
| 469 | Phosphorylation | MSMQKPMTKTSVKAL HHCCCCCCHHHHHHH | - | ||
| 494 | Phosphorylation | EHMFYRRSMVVADSV HHHHHHCHHHHHHHH | - | ||
| 505 | Phosphorylation | ADSVSHITQHLQHQA HHHHHHHHHHHHHHH | - | ||
| 513 | Ubiquitination | QHLQHQALSSISVAK HHHHHHHHHHHHHHH | 27667366 | ||
| 514 | Phosphorylation | HLQHQALSSISVAKK HHHHHHHHHHHHHHH | 22871156 | ||
| 515 | Phosphorylation | LQHQALSSISVAKKR HHHHHHHHHHHHHHH | 22871156 | ||
| 517 | Phosphorylation | HQALSSISVAKKRVI HHHHHHHHHHHHHHC | 22871156 | ||
| 574 | Ubiquitination | TQMKTFKDEELFPLQ CCCCCCCCCCCHHHH | 27667366 | ||
| 657 | Ubiquitination | LESHELLLDCYDKEI HHHCCHHHHHCCHHH | 27667366 | ||
| 677 | Ubiquitination | EHLLDKLCKEIEKDL HHHHHHHHHHHHHHH | 27667366 | ||
| 701 | Ubiquitination | LDDRNPFKVGRKDLA CCCCCCCCCCCHHHH | 27667366 | ||
| 898 | Ubiquitination | KFNRGIRKLGITPEG HHCHHHHHHCCCCCC | 22790023 | ||
| 901 | Ubiquitination | RGIRKLGITPEGQSY HHHHHHCCCCCCHHH | 27667366 | ||
| 936 | S-nitrosocysteine | IRSGGLHCSSNAIRF HHCCCCEECCCCEEE | - | ||
| 936 | S-palmitoylation | IRSGGLHCSSNAIRF HHCCCCEECCCCEEE | 26165157 | ||
| 962 | Ubiquitination | ELVKEEGLAEETLRA HHHHHCCCHHHHHHH | 27667366 | ||
| 1045 | Ubiquitination | KNKLGAAFTDDGFAM CCCCCCEECCCCHHH | 27667366 | ||
| 1089 | Ubiquitination | KEIRAVAKQQNVQST HHHHHHHHHCCCCCC | 22790023 | ||
| 1154 | Phosphorylation | KKEKEEETKTSNGDG HHHHHHHHCCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WASC4_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WASC4_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WASC4_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of WASC4_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
