dbPTM

ZO2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZO2_MOUSE
UniProt AC	Q9Z0U1
Protein Name	Tight junction protein ZO-2
Gene Name	Tjp2
Organism	Mus musculus (Mouse).
Sequence Length	1167
Subcellular Localization	Cell membrane Peripheral membrane protein Cytoplasmic side. Nucleus. Cell junction, tight junction . Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures..
Protein Description	Plays a role in tight junctions and adherens junctions..
Protein Sequence	MEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEVIEEFDGRSFRSGYSERSRHSSHDMLSHSWEGNRERGRPHQRTQSRERERSRGRSLERGLDQEDYGRSRERSRGRSLERGLDRDFVSRDHSRGRSIDRDYDRDYERSYHEAYEPDYGGGYSPSYDRRAHPETRYERSRSREHLRSRSPSPESRSRHEHKGQHDPDRPIGVLLTKSKANEEYGLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPALNDSDSEVEDISEIESNRSFSPEERRQQYSDQDYHSSTEKLKERPSSREETSGRLSRMGATPTPFKSTGDITAAGVTEASREPRYQEEGPVPQPRTAPRVFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSSGGVKKNLRKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLATELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTIRQRLSPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELEEPAEEPLVSSITRSSEPVQHEENIRKSSPEPRAQMRRAASRDQLRDASPPPAFKPEPPKARSQNREDSFDYSKSNLPATAGSEIPGGSTKGYPPPIAAKPAFGRPILKPSTPVPMPESEEVGESTEEQEDAPRSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPPHMSSRPPEPQKAPSRLYQDTRGSYGSDPEEEEYRQQLAAHSKRGYYSQPSRYRDTEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
107	Phosphorylation	QVAPLQGSPPLSHDD EEEECCCCCCCCCCC	15.47	24925903
111	Phosphorylation	LQGSPPLSHDDRGFE CCCCCCCCCCCCCCE	30.55	27087446
127	Phosphorylation	IEEFDGRSFRSGYSE EEEECCCCCCCCCCC	30.46	26824392
130	Phosphorylation	FDGRSFRSGYSERSR ECCCCCCCCCCCCCC	39.82	22817900
139	Phosphorylation	YSERSRHSSHDMLSH CCCCCCCCCCCCHHC	28.40	26239621
140	Phosphorylation	SERSRHSSHDMLSHS CCCCCCCCCCCHHCC	19.85	27087446
145	Phosphorylation	HSSHDMLSHSWEGNR CCCCCCHHCCCCCCC	14.61	26824392
147	Phosphorylation	SHDMLSHSWEGNRER CCCCHHCCCCCCCCC	24.36	27087446
163	Phosphorylation	RPHQRTQSRERERSR CCCCHHHHHHHHHHH	35.18	23140645
169	Phosphorylation	QSRERERSRGRSLER HHHHHHHHHHHHHHH	34.04	29895711
173	Phosphorylation	RERSRGRSLERGLDQ HHHHHHHHHHHCCCH	37.09	26239621
183	Phosphorylation	RGLDQEDYGRSRERS HCCCHHHHHHHHHHH	17.43	29899451
186	Phosphorylation	DQEDYGRSRERSRGR CHHHHHHHHHHHHHH	33.84	27087446
190	Phosphorylation	YGRSRERSRGRSLER HHHHHHHHHHHCHHH	34.04	29895711
194	Phosphorylation	RERSRGRSLERGLDR HHHHHHHCHHHCCCC	37.09	29895711
205	Phosphorylation	GLDRDFVSRDHSRGR CCCCCHHCCCCCCCC	31.80	22324799
209	Phosphorylation	DFVSRDHSRGRSIDR CHHCCCCCCCCCCCC	40.49	22324799
213	Phosphorylation	RDHSRGRSIDRDYDR CCCCCCCCCCCCCCC	31.50	25521595
218	Phosphorylation	GRSIDRDYDRDYERS CCCCCCCCCCCHHHH	17.48	21659605
225	Phosphorylation	YDRDYERSYHEAYEP CCCCHHHHHHHHCCC	20.92	25619855
226	Phosphorylation	DRDYERSYHEAYEPD CCCHHHHHHHHCCCC	15.20	25619855
230	Phosphorylation	ERSYHEAYEPDYGGG HHHHHHHCCCCCCCC	25.63	25619855
234	Phosphorylation	HEAYEPDYGGGYSPS HHHCCCCCCCCCCCC	28.52	25521595
238	Phosphorylation	EPDYGGGYSPSYDRR CCCCCCCCCCCCCCC	22.23	27742792
239	Phosphorylation	PDYGGGYSPSYDRRA CCCCCCCCCCCCCCC	15.62	25521595
241	Phosphorylation	YGGGYSPSYDRRAHP CCCCCCCCCCCCCCC	33.45	27087446
242	Phosphorylation	GGGYSPSYDRRAHPE CCCCCCCCCCCCCCC	19.49	25619855
255	Phosphorylation	PETRYERSRSREHLR CCHHHHHHHHHHHHH	23.75	28507225
257	Phosphorylation	TRYERSRSREHLRSR HHHHHHHHHHHHHHC	43.18	29899451
263	Phosphorylation	RSREHLRSRSPSPES HHHHHHHHCCCCHHH	43.39	27087446
265	Phosphorylation	REHLRSRSPSPESRS HHHHHHCCCCHHHHH	30.86	27087446
267	Phosphorylation	HLRSRSPSPESRSRH HHHHCCCCHHHHHHC	42.41	27087446
270	Phosphorylation	SRSPSPESRSRHEHK HCCCCHHHHHHCCCC	38.65	25159016
294	Ubiquitination	GVLLTKSKANEEYGL EEEEECCCCCHHHCC	57.71	22790023
305	Phosphorylation	EYGLRLGSQIFIKEM HHCCCCCCEEEEEEC	25.37	22817900
320	Ubiquitination	TRTGLATKDGNLHEG CCCCCEECCCCCCCC	59.02	22790023
365	Phosphorylation	QLVVLRDSKQTLINI EEEEEECCCCEEEEE	21.89	29899451
368	Phosphorylation	VLRDSKQTLINIPAL EEECCCCEEEEECCC	33.08	25619855
378	Phosphorylation	NIPALNDSDSEVEDI EECCCCCCCCCCCCH	41.80	18388127
380	Phosphorylation	PALNDSDSEVEDISE CCCCCCCCCCCCHHH	47.71	18388127
386	Phosphorylation	DSEVEDISEIESNRS CCCCCCHHHHHHCCC	44.86	25619855
390	Phosphorylation	EDISEIESNRSFSPE CCHHHHHHCCCCCHH	43.11	25195567
393	Phosphorylation	SEIESNRSFSPEERR HHHHHCCCCCHHHHH	34.03	27087446
395	Phosphorylation	IESNRSFSPEERRQQ HHHCCCCCHHHHHHH	32.42	27087446
403	Phosphorylation	PEERRQQYSDQDYHS HHHHHHHHCCCCCHH	13.08	27742792
404	Phosphorylation	EERRQQYSDQDYHSS HHHHHHHCCCCCHHC	25.18	25521595
408	Phosphorylation	QQYSDQDYHSSTEKL HHHCCCCCHHCHHHH	9.66	27087446
410	Phosphorylation	YSDQDYHSSTEKLKE HCCCCCHHCHHHHHH	32.50	25521595
411	Phosphorylation	SDQDYHSSTEKLKER CCCCCHHCHHHHHHC	27.55	25521595
412	Phosphorylation	DQDYHSSTEKLKERP CCCCHHCHHHHHHCC	39.90	27087446
414	Ubiquitination	DYHSSTEKLKERPSS CCHHCHHHHHHCCCC	66.02	22790023
420	Phosphorylation	EKLKERPSSREETSG HHHHHCCCCCCCCCC	48.53	23684622
421	Phosphorylation	KLKERPSSREETSGR HHHHCCCCCCCCCCC	46.52	30352176
425	Phosphorylation	RPSSREETSGRLSRM CCCCCCCCCCCHHHC	31.56	25777480
426	Phosphorylation	PSSREETSGRLSRMG CCCCCCCCCCHHHCC	25.79	25777480
430	Phosphorylation	EETSGRLSRMGATPT CCCCCCHHHCCCCCC	20.89	29514104
435	Phosphorylation	RLSRMGATPTPFKST CHHHCCCCCCCCCCC	23.20	28507225
437	Phosphorylation	SRMGATPTPFKSTGD HHCCCCCCCCCCCCC	36.68	26239621
440	Ubiquitination	GATPTPFKSTGDITA CCCCCCCCCCCCCCC	48.59	22790023
441	Phosphorylation	ATPTPFKSTGDITAA CCCCCCCCCCCCCCC	37.69	25521595
442	Phosphorylation	TPTPFKSTGDITAAG CCCCCCCCCCCCCCC	39.19	23684622
446	Phosphorylation	FKSTGDITAAGVTEA CCCCCCCCCCCCCHH	18.39	25619855
451	Phosphorylation	DITAAGVTEASREPR CCCCCCCCHHCCCCC	25.56	25619855
454	Phosphorylation	AAGVTEASREPRYQE CCCCCHHCCCCCCCC	30.83	25619855
479	Phosphorylation	PRVFLRPSPEDEAIY CEEEECCCCCCCCCC	34.19	26824392
486	Phosphorylation	SPEDEAIYGPNTKMV CCCCCCCCCCCCCEE	33.31	22817900
500	Phosphorylation	VRFKKGDSVGLRLAG EEEECCCCCCEEECC	27.10	29899451
540	Phosphorylation	DQILKVNTQDFRGLV CEEEEECCHHHHHHC	32.28	28973931
554	Phosphorylation	VREDAVLYLLEIPKG CCCCEEEEEEECCCC	11.57	22817900
565	Phosphorylation	IPKGETVTILAQSRA CCCCCEEEEEECCHH	20.07	28059163
570	Phosphorylation	TVTILAQSRADVYRD EEEEEECCHHHHHHH	24.67	22817900
581	Glutathionylation	VYRDILACGRGDSFF HHHHHHHCCCCCCEE	3.24	24333276
621	Ubiquitination	VDTLYDGKLGHWLAV EEEECCCCCCEEEEH	48.69	22790023
678	Ubiquitination	QRSSGGVKKNLRKSR CCCCCCHHHHHHHCH	38.94	-
684	Phosphorylation	VKKNLRKSREDLAAA HHHHHHHCHHHHHHH	34.17	25521595
693	Phosphorylation	EDLAAAVSVSTKFPA HHHHHHHHHHCCCCH	12.96	25619855
751	Acetylation	PKDAGSEKSSGVVRL CCCCCCCCCCCEEEH	52.17	19851197
751	Ubiquitination	PKDAGSEKSSGVVRL CCCCCCCCCCCEEEH	52.17	22790023
811	Phosphorylation	KTIRQRLSPTSNKSS HHHHHHCCCCCCHHH	28.46	27087446
813	Phosphorylation	IRQRLSPTSNKSSRK HHHHCCCCCCHHHHH	41.37	26745281
814	Phosphorylation	RQRLSPTSNKSSRKL HHHCCCCCCHHHHHH	45.72	25367039
856	Phosphorylation	WFGSLKDSIQQQQNE CCCCHHHHHHHHHCC	22.25	20469934
868	Phosphorylation	QNEAVWVSEGKMEGM HCCCEEEECCCCCCC	25.56	20469934
884	Phosphorylation	DDAEDRMSYLTAMGA CCHHHHHHHHHHHCC	20.20	26239621
885	Phosphorylation	DAEDRMSYLTAMGAD CHHHHHHHHHHHCCC	9.95	26239621
887	Phosphorylation	EDRMSYLTAMGADYL HHHHHHHHHHCCCEE	13.33	26239621
893	Phosphorylation	LTAMGADYLSCDSRL HHHHCCCEECCCCCE	10.44	23984901
895	Phosphorylation	AMGADYLSCDSRLIS HHCCCEECCCCCEEC	15.06	27087446
898	Phosphorylation	ADYLSCDSRLISDFE CCEECCCCCEECCCC	33.06	21743459
902	Phosphorylation	SCDSRLISDFEDTDG CCCCCEECCCCCCCC	40.62	24925903
907	Phosphorylation	LISDFEDTDGEGGAY EECCCCCCCCCCCCC	38.41	24925903
914	Phosphorylation	TDGEGGAYTDNELEE CCCCCCCCCCCCCCC	20.21	25619855
915	Phosphorylation	DGEGGAYTDNELEEP CCCCCCCCCCCCCCC	31.64	24925903
929	Phosphorylation	PAEEPLVSSITRSSE CCCCCCCHHCCCCCC	24.57	25619855
930	Phosphorylation	AEEPLVSSITRSSEP CCCCCCHHCCCCCCC	22.09	25619855
947	Phosphorylation	HEENIRKSSPEPRAQ CHHHHHHCCCCHHHH	41.08	26239621
948	Phosphorylation	EENIRKSSPEPRAQM HHHHHHCCCCHHHHH	36.00	26239621
960	Phosphorylation	AQMRRAASRDQLRDA HHHHHHHHHHHHHHC	35.09	27087446
968	Phosphorylation	RDQLRDASPPPAFKP HHHHHHCCCCCCCCC	42.08	27087446
982	Phosphorylation	PEPPKARSQNREDSF CCCCCCCCCCCCCCC	36.35	25619855
988	Phosphorylation	RSQNREDSFDYSKSN CCCCCCCCCCCCCCC	18.44	25521595
991	Phosphorylation	NREDSFDYSKSNLPA CCCCCCCCCCCCCCC	18.91	25619855
992	Phosphorylation	REDSFDYSKSNLPAT CCCCCCCCCCCCCCC	31.30	25619855
993	Ubiquitination	EDSFDYSKSNLPATA CCCCCCCCCCCCCCC	36.81	22790023
994	Phosphorylation	DSFDYSKSNLPATAG CCCCCCCCCCCCCCC	37.34	25619855
1002	Phosphorylation	NLPATAGSEIPGGST CCCCCCCCCCCCCCC	29.86	25619855
1008	Phosphorylation	GSEIPGGSTKGYPPP CCCCCCCCCCCCCCC	32.62	25521595
1009	Phosphorylation	SEIPGGSTKGYPPPI CCCCCCCCCCCCCCC	31.59	25619855
1030	Phosphorylation	GRPILKPSTPVPMPE CCCCCCCCCCCCCCC	43.70	28507225
1031	Phosphorylation	RPILKPSTPVPMPES CCCCCCCCCCCCCCC	36.51	21149613
1038	Phosphorylation	TPVPMPESEEVGEST CCCCCCCCCCCCCCH	32.94	25293948
1044	Phosphorylation	ESEEVGESTEEQEDA CCCCCCCCHHHCCCC	34.88	28507225
1045	Phosphorylation	SEEVGESTEEQEDAP CCCCCCCHHHCCCCC	38.96	21149613
1095	Phosphorylation	AQKHPDIYAVPIKAP HHHCCCEEEEECCCC	14.66	25521595
1124	Phosphorylation	PEPQKAPSRLYQDTR CCCCCCCCCCCCCCC	39.51	22210690
1127	Phosphorylation	QKAPSRLYQDTRGSY CCCCCCCCCCCCCCC	11.84	23984901
1130	Phosphorylation	PSRLYQDTRGSYGSD CCCCCCCCCCCCCCC	22.77	27087446
1133	Phosphorylation	LYQDTRGSYGSDPEE CCCCCCCCCCCCHHH	24.03	25521595
1134	Phosphorylation	YQDTRGSYGSDPEEE CCCCCCCCCCCHHHH	24.39	27087446
1136	Phosphorylation	DTRGSYGSDPEEEEY CCCCCCCCCHHHHHH	41.58	27087446
1143	Phosphorylation	SDPEEEEYRQQLAAH CCHHHHHHHHHHHHH	19.59	25619855
1151	Phosphorylation	RQQLAAHSKRGYYSQ HHHHHHHHHCCCCCC	21.22	25619855
1155	Phosphorylation	AAHSKRGYYSQPSRY HHHHHCCCCCCCHHC	12.18	25367039
1156	Phosphorylation	AHSKRGYYSQPSRYR HHHHCCCCCCCHHCC	12.03	25367039
1157	Phosphorylation	HSKRGYYSQPSRYRD HHHCCCCCCCHHCCC	27.42	22006019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZO2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZO2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZO2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CXD2_MOUSE	Gjd2	physical	16650609

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZO2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-968 AND TYR-1095, ANDMASS SPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-968, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-263; SER-265;SER-267; SER-968 AND SER-988, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND MASSSPECTROMETRY.	18630941 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107 AND SER-239, ANDMASS SPECTROMETRY.	16452087 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-238, AND MASSSPECTROMETRY.	17242355 [Abstract]