CXD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXD2_MOUSE
• UniProt AC: O54851
• Protein Name: Gap junction delta-2 protein
• Gene Name: Gjd2
• Organism: Mus musculus (Mouse).
• Sequence Length: 321
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
• Protein Description: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell..
• Protein Sequence: MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPAESIGGPGGTGGGGSGGSKREDKKLQNAIVNGVLQNTETTSKETEPDCLEVKELTPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Phosphorylation	AKQRERRYSTVFLAL HHHHHHHCEEEEEEE	18.21	29899451
110	Phosphorylation	KQRERRYSTVFLALD HHHHHHCEEEEEEEC	19.11	16956882
130	Phosphorylation	SIGGPGGTGGGGSGG HCCCCCCCCCCCCCC	38.27	-
135	Phosphorylation	GGTGGGGSGGSKRED CCCCCCCCCCCHHCC	43.16	-
138	Phosphorylation	GGGGSGGSKREDKKL CCCCCCCCHHCCHHH	31.87	-
293	Phosphorylation	GAQAKRKSVYEIRNK HHHHCCCCCCHHCCC	33.68	16956882
306	Phosphorylation	NKDLPRVSVPNFGRT CCCCCCCCCCCCCCC	32.89	16956882
315	Phosphorylation	PNFGRTQSSDSAYV- CCCCCCCCCCCCCC-	35.18	16956882

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
110	S	Phosphorylation	Kinase	PKACA	P17612	PSP
110	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
293	S	Phosphorylation	Kinase	PKACA	P17612	PSP
293	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
306	S	Phosphorylation	Kinase	PKACA	P17612	PSP
306	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
315	S	Phosphorylation	Kinase	PKACA	P17612	PSP
315	S	Phosphorylation	Kinase	PRKACA	P05132	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXD2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CXD2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.