KIF11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF11_MOUSE
• UniProt AC: Q6P9P6
• Protein Name: Kinesin-like protein KIF11
• Gene Name: Kif11
• Organism: Mus musculus (Mouse).
• Sequence Length: 1052
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, spindle pole .
• Protein Description: Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface..
• Protein Sequence: MASQPSSLKKKEEKGRNIQVVVRCRPFNLAERKANAHSVVECDHARKEVSVRTAGLTDKTSKKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRTRTSIIATISPASFNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEESFRAMNGKVTVQEEQIVELVEKIAVLEEELSKATELFMDSKNELDQCKSDLQTKTQELETTQKHLQETKLQLVKEEYVSSALERTEKTLHDTASKLLNTVKETTRAVSGLHSKLDRKRAIDEHNAEAQESFGKNLNSLFNNMEELIKDGSAKQKAMLDVHKTLFGNLMSSSVSALDTITTTALESLVSIPENVSARVSQISDMILEEQSLAAQSKSVLQGLIDELVTDLFTSLKTIVAPSVVSILNINKQLQHIFRASSTVAEKVEDQKREIDSFLSILCNNLHELRENTVSSLVESQKLCGDLTEDLKTIKETHSQELCQLSSSWAERFCALEKKYENIQKPLNSIQENTELRSTDIINKTTVHSKKILAESDGLLQELRHFNQEGTQLVEESVGHCSSLNSNLETVSQEITQKCGTLNTSTVHFSDQWASCLSKRKEELENLMEFVNGCCKASSSEITKKVREQSAAVANQHSSFVAQMTSDEESCKAGSLELDKTIKTGLTKLNCFLKQDLKLDIPTGMTPERKKYLYPTTLVRTEPREQLLDQLQKKQPPMMLNSSEASKETSQDMDEEREALEQCTEELVSPETTEHPSADCSSSRGLPFFQRKKPHGKDKENRGLNPVEKYKVEEASDLSISKSRLPLHTSINL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASQPSSLKK -----CCCCCHHHCC	55.25	24759943
6	Phosphorylation	--MASQPSSLKKKEE --CCCCCHHHCCHHH	40.44	24759943
7	Phosphorylation	-MASQPSSLKKKEEK -CCCCCHHHCCHHHC	51.39	29514104
38	Phosphorylation	ERKANAHSVVECDHA HHHCCCCCEEECHHH	26.00	27149854
124	Phosphorylation	ERSPNEVYTWEEDPL CCCCCCCEECCCCCC	10.43	22817900
145	Acetylation	TLHQIFEKLTDNGTE HHHHHHHHHCCCCCE	46.03	-
398	Phosphorylation	AREKNGVYISEESFR HHHHCCEEECHHHHH	10.50	-
403	Phosphorylation	GVYISEESFRAMNGK CEEECHHHHHHHCCC	18.91	22006019
457	Phosphorylation	KSDLQTKTQELETTQ HHHHHHHHHHHHHHH	30.57	-
487	Phosphorylation	VSSALERTEKTLHDT HHHHHHHHHHHHHHH	32.24	-
510	Phosphorylation	KETTRAVSGLHSKLD HHHHHHHHHHHHHHH	34.35	27841257
515	Acetylation	AVSGLHSKLDRKRAI HHHHHHHHHHHHHHH	43.59	7617921
660	Phosphorylation	LQHIFRASSTVAEKV HHHHHHHCCHHHHHH	23.45	25177544
922	Phosphorylation	DLKLDIPTGMTPERK CCCCCCCCCCCHHHH	39.66	25159016
925	Phosphorylation	LDIPTGMTPERKKYL CCCCCCCCHHHHHCC	24.28	26824392
969	Phosphorylation	SEASKETSQDMDEER HHHHHHHCCCHHHHH	25.85	22942356
983	Phosphorylation	REALEQCTEELVSPE HHHHHHHHHHHCCCC	31.99	25619855
988	Phosphorylation	QCTEELVSPETTEHP HHHHHHCCCCCCCCC	29.64	25619855
991	Phosphorylation	EELVSPETTEHPSAD HHHCCCCCCCCCCCC	40.65	25619855
992	Phosphorylation	ELVSPETTEHPSADC HHCCCCCCCCCCCCC	30.54	25619855
996	Phosphorylation	PETTEHPSADCSSSR CCCCCCCCCCCCCCC	38.35	25619855
1048	Phosphorylation	KSRLPLHTSINL--- CCCCCCCCCCCC---	38.70	29550500
1049	Phosphorylation	SRLPLHTSINL---- CCCCCCCCCCC----	9.95	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIF11_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
925	T	Phosphorylation	Phosphorylated exclusively on serine during S phase, but on both serine and Thr-925 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF11_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KIF11_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.