DDX6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX6_MOUSE
• UniProt AC: P54823
• Protein Name: Probable ATP-dependent RNA helicase DDX6 {ECO:0000305}
• Gene Name: Ddx6
• Organism: Mus musculus (Mouse).
• Sequence Length: 483
• Subcellular Localization: Cytoplasm, P-body . Cytoplasm . Nucleus . Upon cellular stress, relocalizes to stress granules.
• Protein Description: In the process of mRNA degradation, plays a role in mRNA decapping (By similarity). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts. [PubMed: 26098573]
• Protein Sequence: MSTARTENPVIMGLSSQNGQLRGPVKASAGPGGGGTQPQPQLNQLKNTSTINNGTPQQAQSMAATIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPAEDEKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	AGPGGGGTQPQPQLN CCCCCCCCCCCCCHH	40.11	-
48	Phosphorylation	QLNQLKNTSTINNGT CHHHCCCCCCCCCCC	26.17	26745281
49	Phosphorylation	LNQLKNTSTINNGTP HHHCCCCCCCCCCCH	36.36	26745281
50	Phosphorylation	NQLKNTSTINNGTPQ HHCCCCCCCCCCCHH	26.19	26745281
55	Phosphorylation	TSTINNGTPQQAQSM CCCCCCCCHHHHHHH	21.76	26745281
61	Phosphorylation	GTPQQAQSMAATIKP CCHHHHHHHHCEECC	17.26	26745281
67	Acetylation	QSMAATIKPGDDWKK HHHHCEECCCCCHHH	38.30	156457
73	Acetylation	IKPGDDWKKTLKLPP ECCCCCHHHHCCCCC	42.76	90291
87	Phosphorylation	PKDLRIKTSDVTSTK CCCCEEEECCCCCCC	27.99	28066266
88	Phosphorylation	KDLRIKTSDVTSTKG CCCEEEECCCCCCCC	25.69	28066266
91	Phosphorylation	RIKTSDVTSTKGNEF EEEECCCCCCCCCHH	35.35	28066266
92	Phosphorylation	IKTSDVTSTKGNEFE EEECCCCCCCCCHHH	28.15	28066266
93	Phosphorylation	KTSDVTSTKGNEFED EECCCCCCCCCHHHH	33.34	28066266
104	Acetylation	EFEDYCLKRELLMGI HHHHHHHHHHHHHHH	40.02	22826441
232	Acetylation	RILDLIKKGVAKVDH HHHHHHHHCCCCCCE	52.18	19851993
236	Acetylation	LIKKGVAKVDHVQMI HHHHCCCCCCEEEEE	45.87	19852003
250	Acetylation	IVLDEADKLLSQDFV EECCHHHHHCCCHHH	59.38	19852013
312	Phosphorylation	TLKGVTQYYAYVTER CCCCCCEEEEEHHHH	4.82	18563927
313	Phosphorylation	LKGVTQYYAYVTERQ CCCCCEEEEEHHHHH	5.01	-
315	Phosphorylation	GVTQYYAYVTERQKV CCCEEEEEHHHHHHH	7.56	-
324	S-nitrosocysteine	TERQKVHCLNTLFSR HHHHHHHHHHHHHHH	3.34	-
324	S-nitrosylation	TERQKVHCLNTLFSR HHHHHHHHHHHHHHH	3.34	20925432
353	Acetylation	RVELLAKKISQLGYS HHHHHHHHHHHHCHH	41.82	22826441
462	Phosphorylation	TEIKPIPSNIDKSLY CCEECCCCCCCCHHE	47.33	26370283
467	Phosphorylation	IPSNIDKSLYVAEYH CCCCCCCHHEEEEEC	22.61	23984901
469	Phosphorylation	SNIDKSLYVAEYHSE CCCCCHHEEEEECCC	12.52	23984901
473	Phosphorylation	KSLYVAEYHSEPAED CHHEEEEECCCCCCC	10.83	23984901
475	Phosphorylation	LYVAEYHSEPAEDEK HEEEEECCCCCCCCC	44.36	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DDX6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.