dbPTM

CGNL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CGNL1_MOUSE
UniProt AC	Q6AW69
Protein Name	Cingulin-like protein 1
Gene Name	Cgnl1
Organism	Mus musculus (Mouse).
Sequence Length	1298
Subcellular Localization	Cell junction, tight junction . Localizes to the apical junction complex composed of tight and adherens junctions. In the liver and kidney, it is also found along non-junctional actin filament bundles in addition to the apical junction.
Protein Description	May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons..
Protein Sequence	MELYFGEYQHVQQEYGVHLRLASGDTPKPRNSQPSKAGSYGVSIRVQGIDGHPYIVLNNTERCLAGTPFPENAPSFPSSVINNLSLHPSNGTVLKENTPEELQLPENPYLQTSPLRGQKQFSLHEGRNGVLERKDGPTKLPHVLNFQRHPELLQPYDPEKNEVNAKKHHPPESPWLRNATEDGTNCKKSRNCFPKSYGSQPNSPTSEDLAKTNMTAIRLCSSVVIEDPQKQTSVCVNVQRCAKEGVGEETLSPRRKSPTAPSPQAYSETKKNRPDVLPFRRQDSAGPILDGARSRRSSSSSTTPTSATSLYKFLLDDQECAIHADSVNRHENRRYIPFLPGTGRDIDTCSIPGVDQLIEKFDQKPGLQRRGRSGKRNRINPDDRKRSRSVDSAFPFGLQGNTEYLTEFSRNLGKSSEHLLRPSQVFPQRSVAQEHRGKHSPSSPPAKLQGGAQGAHPKPPLQNKDGKVLNKGRQESTGACAPSLPAPNKKEEEIKIATATLMLQNRAVAATSDSGAKKISVKTFPSDSSTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGGTDNEDATKRKVNLVFEKIQTLKSRAAGSAQGSNQAPNSPSEGNSLLDQKNKLILEVSELQQQLQLEMKNQQNIKEERERMREDLEELRVRHQSQVEETATLQRRLEESEGELRKSLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSTKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAFRESVEEATKNVEVLASRSNSSEQSQAEADLREKVLKEENEKLQGRIAELERRAAQLQRQMEDVKGDEAQAKETLRKCESEVQQLEEALVHARKEEKEATCARRALEKELEQAQRELSQVSQEQKELLEKLRDEAEQKEQLRKLKNEMESERWHLDKTIQKLQKEMADIAEASRTSSLELQKQLGEYKEKNRRELAEMQTQLKEKCLEVEKARLAASKMQDELRLKEEELQDYQRAEEEALTKRQLLEQSLKDLEYELEAKSHLKDDRSRLIKQMEDKVSQLEIELEEERTNADLLSERITWSREQMEQMRSELLQEKAAKQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLENEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMGVNEQLQGQLNSLKKGLRLKTLSSKVLDDSDDDDLSSDAGSLYEAPLSYAFPKDSTIASQI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	GVHLRLASGDTPKPR CCEEEECCCCCCCCC	41.62	29514104
36	Ubiquitination	PRNSQPSKAGSYGVS CCCCCCCCCCCCEEE	64.55	-
109	Phosphorylation	LQLPENPYLQTSPLR HCCCCCCCCCCCCCC	24.03	23984901
112	Phosphorylation	PENPYLQTSPLRGQK CCCCCCCCCCCCCCC	29.71	23984901
113	Phosphorylation	ENPYLQTSPLRGQKQ CCCCCCCCCCCCCCE	14.69	27180971
119	Ubiquitination	TSPLRGQKQFSLHEG CCCCCCCCEEECCCC	57.02	-
122	Phosphorylation	LRGQKQFSLHEGRNG CCCCCEEECCCCCCC	26.73	29514104
139	Ubiquitination	ERKDGPTKLPHVLNF EECCCCCCCCCCCCC	64.25	-
160	Ubiquitination	LQPYDPEKNEVNAKK CCCCCCCCCCCCCHH	64.89	-
195	Ubiquitination	KSRNCFPKSYGSQPN HHCCCCCHHHCCCCC	35.74	-
196	Phosphorylation	SRNCFPKSYGSQPNS HCCCCCHHHCCCCCC	34.66	27087446
197	Phosphorylation	RNCFPKSYGSQPNSP CCCCCHHHCCCCCCC	27.24	22324799
199	Phosphorylation	CFPKSYGSQPNSPTS CCCHHHCCCCCCCCH	33.94	25521595
203	Phosphorylation	SYGSQPNSPTSEDLA HHCCCCCCCCHHHHH	35.92	25521595
205	Phosphorylation	GSQPNSPTSEDLAKT CCCCCCCCHHHHHHH	44.56	27742792
206	Phosphorylation	SQPNSPTSEDLAKTN CCCCCCCHHHHHHHC	32.28	27742792
211	Ubiquitination	PTSEDLAKTNMTAIR CCHHHHHHHCHHHHH	47.96	-
250	Phosphorylation	KEGVGEETLSPRRKS HCCCCCCCCCCCCCC	28.38	30635358
252	Phosphorylation	GVGEETLSPRRKSPT CCCCCCCCCCCCCCC	24.63	27087446
257	Phosphorylation	TLSPRRKSPTAPSPQ CCCCCCCCCCCCCHH	26.18	25521595
259	Phosphorylation	SPRRKSPTAPSPQAY CCCCCCCCCCCHHHC	59.29	26824392
262	Phosphorylation	RKSPTAPSPQAYSET CCCCCCCCHHHCCCH	27.46	27087446
266	Phosphorylation	TAPSPQAYSETKKNR CCCCHHHCCCHHCCC	11.20	29472430
267	Phosphorylation	APSPQAYSETKKNRP CCCHHHCCCHHCCCC	41.63	29899451
269	Phosphorylation	SPQAYSETKKNRPDV CHHHCCCHHCCCCCC	41.18	29472430
284	Phosphorylation	LPFRRQDSAGPILDG CCCCCCCCCCCCCCC	27.13	27087446
294	Phosphorylation	PILDGARSRRSSSSS CCCCCCCCCCCCCCC	31.35	26824392
297	Phosphorylation	DGARSRRSSSSSTTP CCCCCCCCCCCCCCC	33.20	21082442
298	Phosphorylation	GARSRRSSSSSTTPT CCCCCCCCCCCCCCC	32.21	25521595
299	Phosphorylation	ARSRRSSSSSTTPTS CCCCCCCCCCCCCCC	29.56	25521595
300	Phosphorylation	RSRRSSSSSTTPTSA CCCCCCCCCCCCCCH	33.38	25521595
301	Phosphorylation	SRRSSSSSTTPTSAT CCCCCCCCCCCCCHH	37.94	21082442
302	Phosphorylation	RRSSSSSTTPTSATS CCCCCCCCCCCCHHH	38.45	27087446
303	Phosphorylation	RSSSSSTTPTSATSL CCCCCCCCCCCHHHH	26.90	27087446
305	Phosphorylation	SSSSTTPTSATSLYK CCCCCCCCCHHHHHH	28.97	26643407
306	Phosphorylation	SSSTTPTSATSLYKF CCCCCCCCHHHHHHH	30.65	26643407
308	Phosphorylation	STTPTSATSLYKFLL CCCCCCHHHHHHHHH	21.02	23984901
309	Phosphorylation	TTPTSATSLYKFLLD CCCCCHHHHHHHHHC	29.44	23984901
311	Phosphorylation	PTSATSLYKFLLDDQ CCCHHHHHHHHHCCC	10.24	29472430
348	Phosphorylation	GTGRDIDTCSIPGVD CCCCCCCCCCCCCHH	14.42	21743459
350	Phosphorylation	GRDIDTCSIPGVDQL CCCCCCCCCCCHHHH	33.63	26824392
364	Ubiquitination	LIEKFDQKPGLQRRG HHHHHHCCCCCCCCC	42.78	-
387	Phosphorylation	NPDDRKRSRSVDSAF CCCHHHHHCCCCCCC	31.76	26239621
389	Phosphorylation	DDRKRSRSVDSAFPF CHHHHHCCCCCCCCC	31.36	27087446
392	Phosphorylation	KRSRSVDSAFPFGLQ HHHCCCCCCCCCCCC	29.65	27087446
415	Phosphorylation	FSRNLGKSSEHLLRP HHHHCCCCCCHHCCH	38.88	26824392
416	Phosphorylation	SRNLGKSSEHLLRPS HHHCCCCCCHHCCHH	32.30	26239621
423	Phosphorylation	SEHLLRPSQVFPQRS CCHHCCHHHCCCCHH	32.32	25168779
440	Phosphorylation	QEHRGKHSPSSPPAK HHHCCCCCCCCCCHH	29.93	23684622
442	Phosphorylation	HRGKHSPSSPPAKLQ HCCCCCCCCCCHHHC	59.50	23684622
443 (in isoform 4)	Phosphorylation	-	37.98	27818261
443 (in isoform 3)	Phosphorylation	-	37.98	27818261
443 (in isoform 5)	Phosphorylation	-	37.98	27818261
443	Phosphorylation	RGKHSPSSPPAKLQG CCCCCCCCCCHHHCC	37.98	26824392
483	Phosphorylation	STGACAPSLPAPNKK CCCCCCCCCCCCCCH	28.58	-
553	Ubiquitination	QTNEETAKQILYNYL HCCHHHHHHHHHHHH	45.34	-
561	Ubiquitination	QILYNYLKEGGTDNE HHHHHHHHHCCCCCH	43.91	-
574	Ubiquitination	NEDATKRKVNLVFEK CHHHHHHHHHHHHHH	36.71	-
581	Ubiquitination	KVNLVFEKIQTLKSR HHHHHHHHHHHHHHH	28.75	-
587	Phosphorylation	EKIQTLKSRAAGSAQ HHHHHHHHHHCCCCC	30.20	23984901
592	Phosphorylation	LKSRAAGSAQGSNQA HHHHHCCCCCCCCCC	16.82	23984901
596	Phosphorylation	AAGSAQGSNQAPNSP HCCCCCCCCCCCCCC	17.43	23984901
601	Phosphorylation	QGSNQAPNSPSEGNS CCCCCCCCCCCCCCC	70.35	24719451
602	Phosphorylation	GSNQAPNSPSEGNSL CCCCCCCCCCCCCCH	28.83	25521595
604	Phosphorylation	NQAPNSPSEGNSLLD CCCCCCCCCCCCHHH	58.94	27087446
608	Phosphorylation	NSPSEGNSLLDQKNK CCCCCCCCHHHHHHC	40.96	26160508
615	Ubiquitination	SLLDQKNKLILEVSE CHHHHHHCHHHHHHH	43.89	-
657	Phosphorylation	ELRVRHQSQVEETAT HHHHHHHHHHHHHHH	30.02	28285833
678	Ubiquitination	ESEGELRKSLEELFQ HCHHHHHHHHHHHHH	72.51	-
679	Phosphorylation	SEGELRKSLEELFQV CHHHHHHHHHHHHHH	34.28	25521595
705	Phosphorylation	RDLQDQLSEMHDELD HHHHHHHHHHHHHHH	27.52	-
809	Phosphorylation	VLASRSNSSEQSQAE HHHCCCCCCHHHHHH	36.18	22942356
866	Glutathionylation	AKETLRKCESEVQQL HHHHHHHHHHHHHHH	5.86	24333276
1089	Phosphorylation	DLLSERITWSREQME HHHHHHHHCCHHHHH	24.49	21149613
1091	Phosphorylation	LSERITWSREQMEQM HHHHHHCCHHHHHHH	19.79	21149613
1118	Phosphorylation	DLECDKISLERQNKD CCCCCHHCHHHCCCC	29.89	25159016
1202	Phosphorylation	TDQKDQLSLRLKAMK CCHHHHHHHHHHHHH	13.05	22942356
1258	Phosphorylation	KKGLRLKTLSSKVLD HHCCCHHHHHCCCCC	36.14	28066266
1260	Phosphorylation	GLRLKTLSSKVLDDS CCCHHHHHCCCCCCC	33.09	28066266
1261	Phosphorylation	LRLKTLSSKVLDDSD CCHHHHHCCCCCCCC	29.87	28066266
1267	Phosphorylation	SSKVLDDSDDDDLSS HCCCCCCCCCCCCCC	42.48	27180971
1273	Phosphorylation	DSDDDDLSSDAGSLY CCCCCCCCCCCCHHH	32.92	26643407
1274	Phosphorylation	SDDDDLSSDAGSLYE CCCCCCCCCCCHHHC	38.48	25293948
1278	Phosphorylation	DLSSDAGSLYEAPLS CCCCCCCHHHCCCHH	29.51	25293948
1280	Phosphorylation	SSDAGSLYEAPLSYA CCCCCHHHCCCHHHC	16.25	22324799
1285	Phosphorylation	SLYEAPLSYAFPKDS HHHCCCHHHCCCCCC	17.23	22324799
1286	Phosphorylation	LYEAPLSYAFPKDST HHCCCHHHCCCCCCC	21.68	22324799

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CGNL1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CGNL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CGNL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CGNL1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CGNL1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205; SER-298; SER-299;SER-389 AND SER-392, AND MASS SPECTROMETRY.	17242355 [Abstract]