NDST4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDST4_MOUSE
• UniProt AC: Q9EQW8
• Protein Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
• Gene Name: Ndst4
• Organism: Mus musculus (Mouse).
• Sequence Length: 872
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity..
• Protein Sequence: MNLILKFRRSFRTLIVLLATFCLVSILISAYFLYSGYKQEMTLIETTAEAECADIKDLPYRSIELRTIKPIDTSKTDPTVLLFVESQYSQLGQDIIAILESSRFQYQMVIAPGKGDIPPLTDSGKGKYTLIIYENILKYVSMDSWNRELLEKYCIEYSVSIIGFHKANENSLPTTQLKGFPLNLFNNVALKDCSVNPQSPLLHITKGPKVEKGPLPGEDWTIFQYNHSTYQPVLLTELQSEKSLSFLSSQTLYATIIQDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNVKDVKALLETQNLLRTQVANFTFNLGFSGKFYHTGTEEEDEGDDLLLRSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKEFALEHGIPINLGYAVAPHHSGVYPVHIQLYAAWKKVWGIQVTSTEEYPHLKPARYRKGFIHNSIMVLPRQTCGLFTHTIFYKEYPGGPQELDKSIKGGELFLTILLNPISIFMTHLSNYGNDRLGLYTFVNLANFVHSWTNLKLQTLPPVQLAHKYFELFPEQKDPLWQNPCDDKRHKDIWSREKTCDHLPKFLVIGPQKTGTTALYLFLLMHPSIISNLPSPKTFEEVQFFNGNNYHKGIEWYMDFFPTPSNITSDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALRFNFYEVITTGHWAPPDLKTLQRRCLVPGWYAVHIERWLAYFSTSQLLIIDGQQLRSDPATVMDEVQKFLGVTPHYNYSEALTFDPQKGFWCQLLEGGKTKCLGKSKGRKYPPMDSESRTFLSSYYRDHNVELSKLLHRLGQPLPSWLRQELQKVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
226	N-linked_Glycosylation	DWTIFQYNHSTYQPV CCEEEEECCCCCCCE	16.32	-
341	N-linked_Glycosylation	LLRTQVANFTFNLGF HHHHEEEEEEEEEEC	37.32	-
391	N-linked_Glycosylation	MQPHLFHNESSLVEQ CCCHHHCCCCHHHHH	43.44	-
657	N-linked_Glycosylation	DFFPTPSNITSDFLF CCCCCCCCCCHHHHC	42.64	-
793	N-linked_Glycosylation	LGVTPHYNYSEALTF HCCCCCCCHHHCCCC	30.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDST4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDST4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDST4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDST4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.