XPO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XPO1_MOUSE
• UniProt AC: Q6P5F9
• Protein Name: Exportin-1
• Gene Name: Xpo1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1071
• Subcellular Localization: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm (By similarity)..
• Protein Description: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity)..
• Protein Sequence: MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKAKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFETLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHGQLLEKRLNLREALMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDIPPRRQLYLTVLSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTEIIMTKKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTPLNPGNPVNNQMFIQDYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEERETALRQAQEEKHKLQMSVPGILNPHEIPEEMCD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Glutathionylation	LLDNVVNCLYHGEGA HHHHHHHHHHCCCHH	2.42	24333276
164	S-nitrosylation	SRTSESLCQNNMVIL CCCCHHHHHCCCHHH	5.91	24926564
323	Phosphorylation	QNFIQNLSLFLCTFL HHHHHHHHHHHHHHH	25.32	21454597
384	Phosphorylation	AAELYRESPFSTSAS HHHHHHHCCCCCCCC	23.42	29472430
387	Phosphorylation	LYRESPFSTSASPLL HHHHCCCCCCCCCCC	25.49	21149613
388	Phosphorylation	YRESPFSTSASPLLS HHHCCCCCCCCCCCC	28.79	21149613
389	Phosphorylation	RESPFSTSASPLLSG HHCCCCCCCCCCCCC	26.08	21149613
391	Phosphorylation	SPFSTSASPLLSGSQ CCCCCCCCCCCCCCC	18.82	21149613
395	Phosphorylation	TSASPLLSGSQHFDI CCCCCCCCCCCCCCC	44.04	21149613
397	Phosphorylation	ASPLLSGSQHFDIPP CCCCCCCCCCCCCCC	19.67	25777480
446	Acetylation	EVVREFMKDTDSINL HHHHHHHCCCCCCCH	63.90	23806337
448	Phosphorylation	VREFMKDTDSINLYK HHHHHCCCCCCCHHH	26.57	-
450	Phosphorylation	EFMKDTDSINLYKNM HHHCCCCCCCHHHHH	18.57	28066266
454	Phosphorylation	DTDSINLYKNMRETL CCCCCCHHHHHHHHH	8.88	-
455	Acetylation	TDSINLYKNMRETLV CCCCCHHHHHHHHHH	47.65	23236377
455	Ubiquitination	TDSINLYKNMRETLV CCCCCHHHHHHHHHH	47.65	-
455	Malonylation	TDSINLYKNMRETLV CCCCCHHHHHHHHHH	47.65	26320211
514	Acetylation	AMHEEDEKRFLVTVI CCCHHHHHHHHHHHH	61.85	30985939
531	Ubiquitination	LLGLCEQKRGKDNKA HHHHHHHHCCCCCCE	40.60	-
563	Acetylation	RAHWKFLKTVVNKLF HHHHHHHHHHHHHHH	42.26	22826441
686	Acetylation	LKDPETVKQLGSILK CCCHHHHHHHHHHHH	47.42	23236377
693	Ubiquitination	KQLGSILKTNVRACK HHHHHHHHHCHHHHH	36.06	-
693	Acetylation	KQLGSILKTNVRACK HHHHHHHHHCHHHHH	36.06	23954790
700	Ubiquitination	KTNVRACKAVGHPFV HHCHHHHHHHCCCHH	45.16	-
700	Malonylation	KTNVRACKAVGHPFV HHCHHHHHHHCCCHH	45.16	26320211
764	Phosphorylation	KLISGWVSRSNDPQM HHHHHHHHCCCCHHH	24.39	22817900
1030	Phosphorylation	KEFAGEDTSDLFLEE HHHCCCCCHHHHHHH	21.60	28066266
1031	Phosphorylation	EFAGEDTSDLFLEER HHCCCCCHHHHHHHH	44.64	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XPO1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XPO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XPO1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FABPH_HUMAN	FABP3	physical	20360068
XPO1_HUMAN	XPO1	physical	20360068
XDH_HUMAN	XDH	physical	20360068
TZAP_HUMAN	ZBTB48	physical	26496610
NUP98_HUMAN	NUP98	physical	26496610
CCNK_HUMAN	CCNK	physical	26496610
PRP4B_HUMAN	PRPF4B	physical	26496610
GANAB_HUMAN	GANAB	physical	26496610
SCNM1_HUMAN	SCNM1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.