FABPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FABPH_HUMAN
• UniProt AC: P05413
• Protein Name: Fatty acid-binding protein, heart
• Gene Name: FABP3
• Organism: Homo sapiens (Human).
• Sequence Length: 133
• Subcellular Localization: Cytoplasm.
• Protein Description: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters..
• Protein Sequence: MVDAFLGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDILTLKTHSTFKNTEISFKLGVEFDETTADDRKVKSIVTLDGGKLVHLQKWDGQETTLVRELIDGKLILTLTHGTAVCTRTYEKEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVDAFLGTW ------CCCCCCEEE	7.96	22223895
8	Phosphorylation	MVDAFLGTWKLVDSK CCCCCCEEEEECCCC	22.90	22673903
20	Phosphorylation	DSKNFDDYMKSLGVG CCCCHHHHHHHCCCC	14.32	7691977
23	Phosphorylation	NFDDYMKSLGVGFAT CHHHHHHHCCCCHHH	17.52	-
30	Phosphorylation	SLGVGFATRQVASMT HCCCCHHHHHHHHCC	21.26	28857561
35	Phosphorylation	FATRQVASMTKPTTI HHHHHHHHCCCCEEE	28.29	26437602
37	Phosphorylation	TRQVASMTKPTTIIE HHHHHHCCCCEEEEE	31.23	28857561
40	Phosphorylation	VASMTKPTTIIEKNG HHHCCCCEEEEEECC	31.98	26437602
41	Phosphorylation	ASMTKPTTIIEKNGD HHCCCCEEEEEECCC	28.60	26437602
54	Phosphorylation	GDILTLKTHSTFKNT CCEEEEEECCCCCCC	24.95	26437602
56	Phosphorylation	ILTLKTHSTFKNTEI EEEEEECCCCCCCEE	40.55	26437602
57	Phosphorylation	LTLKTHSTFKNTEIS EEEEECCCCCCCEEE	30.90	26437602
61	Phosphorylation	THSTFKNTEISFKLG ECCCCCCCEEEEEEE	34.97	24719451
64	Phosphorylation	TFKNTEISFKLGVEF CCCCCEEEEEEECEE	15.31	24719451
83	Phosphorylation	ADDRKVKSIVTLDGG CCCCEEEEEEEEECC	25.86	-
86	Phosphorylation	RKVKSIVTLDGGKLV CEEEEEEEEECCEEE	19.91	30301811
117	Phosphorylation	IDGKLILTLTHGTAV ECCEEEEEEECCEEE	23.71	22673903
119	Phosphorylation	GKLILTLTHGTAVCT CEEEEEEECCEEEEE	17.02	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
20	Y	Phosphorylation	Kinase	TYR-KINASES	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FABPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FABPH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP62_HUMAN	NUP62	physical	25416956
SHOT1_HUMAN	KIAA1598	physical	25416956
FKB1A_HUMAN	FKBP1A	physical	26344197
NUP62_HUMAN	NUP62	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Characterization and amino acid sequence of a fatty acid-bindingprotein from human heart.";
Offner G.D., Brecher P., Sawlivich W.B., Costello C.E., Troxler R.F.;
Biochem. J. 252:191-198(1988).
Cited for: PROTEIN SEQUENCE OF 2-133.
PubMed: 3421901