SZT2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SZT2_MOUSE
• UniProt AC: A2A9C3
• Protein Name: KICSTOR complex protein SZT2 {ECO:0000305}
• Gene Name: Szt2 {ECO:0000303|PubMed:19624305, ECO:0000312|MGI:MGI:3033336}
• Organism: Mus musculus (Mouse).
• Sequence Length: 3431
• Subcellular Localization: Lysosome membrane . Peroxisome . Localization to lysosomes is amino acid-independent.
• Protein Description: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids (By similarity). In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. [PubMed: 28199306]
• Protein Sequence: MASERPEPEVEEAGQVFLLMKKDYRISRNVRLAWFLNHLHQTVQATPQELLLQSEQELEVLSVLPPGWQPDEPVVPRPFLLVPSTRVTFLAWQYRFVIELDLSPSTGIVDDSTGEILFDEVFHALSRCLGGLLRPFRVPGSCINFQPEIYVTIQAYSSIIGLQSHQVLVQGCLLDPSQREAFLQQVYEQLCLFEDKVATMLQQQYEPQGQAEDQSPESGESLGRKVGVSMVTADLGLVSMIRQGILALQLLPSNSSAGIIVITDGVTSVPDVAVCETLLNQLRSGTVACSFVQVGGVYSYDCSFGHVPNVELMKFIAMATFGSYLSTCPETEPGNLGLTVYHRAFLLYSFLRSGEALNPEYYCGSQHRLFNEHLVSASSNPALALRRKKHTEKEVPADLVSTVSVRLREGYSVREVTLAKGGSQLEVKLVLLWKHNMRIEYVAVAPWPLEPEGPRGTRVEVTMEGGYDILHDVSCALRQPIRSLYRTHVIRRFWNTLQSINQTDQMLAHLQSFSSVPEHFTLPDSTKSGVPLFYIPPGSSTPVLSLQHSGSDSSHAQFAAYWKPVLSMDANSWQRWLHMHRLVLILEHDTPLPKHLHTPGSNGRYSTIQCRISHSSLTSLLRDWSSFVLVEGYSYVKLLSSAPDQPPSSFYMVRIISKTPCMVLRLGFPIGTPAQARHKIVSGLKEEILRLRFPHRVQSKEPTPKVKRKGLGGVGGSSPSKSPPTLGPQQALSDRPCLVVLHKPLDKLLIRYEKLPLDYRAPFLLTLEPPGPLPLVSGRSASSSLASLSRYLYHRRWLWSVPSGLAPTLPLSATAQLLSVLTEVRLSEGFHFACSGEGIINMVLELPVQNEPLGQAAAEEKHTCVVQYILFPPHSTSTKDSFSTDDDNDVEVEALEGDSELNLVTEVWVEPQYGRVGPGPENWKHLQDLTYSEIPQALHPRDAACIGSLLTFEYLIQLCQSKEWGPLPPEPRLSDGLDQRGDTCVHEIPFHFDLLGLLPQCQQLQMFFLLLSREPEGVPLAEGPCPTNDMVLCLLHSCLGQELSDREIPLTPADQAAFLNEVLRRSLRDPGPEGPPVGGHAVAKDRAGNSTQASGDSTLPSQSVVIPGVLRSSISAQPPQWHCYARLLGPQHVFLTFLPATFSDVQHLTAYGLESSFQEETKPKLGDWSGAPSLKDPGATGTKATESQVPTLSVTLASDSAQDSGEPSTPSCQDLAANSGRQAPQTEGADGPRTRCPVYIYSCSLEALREQMVGLQPPQAPRDLIFRAQDLDHPSSSSAWMEPRCKEAATHCALLQEHAQRCFVRGLFRSLQQAQSVTCQDLLTAVDACEELLQEIDITSFLLALCGHTWGLPHAPPSPGPLSPGPFSSSIEEGPEPRERAILVSESSIETEDLSEPEFQSSRVSGNLDPGPEISLTDVCQLRGEAHDALHSLIQEKFLEISRLHFRTVPSNPHYFFYCPPSSRREDEGPRDTVDRKISDLEFSEAELVGEEGDTSACCVVTESDPELEVEYRESREPDLGPAGLDSASLSDADTVNPDEDSFSILGGDSPTGPDSLMHDLPPLFLHLTCSVRLRGQHSSVPVCSLPTCLGQVLSSLEGPPIGGRVPLRDLSITLDVFVLTLPLEVELPPASDPQHHRSTSESSASFPRSPGQPSSLRSDDGLGPPLPPPEEERHPGLSSLAMPHRLAIESTMNEIRWLLEDEMVGALRRGGIPQSPALHRAAAHIHSSSGRPTCLRQAPPLSFVFGPERSLTQFKEEFRRLHLPGHVLLEDPDSGFFFVAAGQQPGVLHGEPPSAAWAWHNHEDRAEDAEGEVLTASPQVPGSLEDSEGTPLISLPSLSQGGSQPGPSRGLSLMSSQGSVDSDHLGYDGGSSGSDSEGPGETLGEKALFTLRTPPGPAPPQPSLPVLPGPSLPDFWLIVRILQDRVEVYAHARSLSREDGGPGAECRHLQQFLVRRVGEICREVNQRLLLQDLHDSHVCNSLLVAESEEDLWRSETPFHSRQRAVLPSDDFAADESCAPRGYLAATMQFVPGHFSCDVVWGTVIRVHSRLKMGPSMGVSRAIQALRSVLNAFSVVNRKNMFVYQERATKAVYYLRLLETSCSDRPWEGDTLPPSLALSRSQEPISSEDSVAPRSPLDMASSRSSDAVRPVGQVDRHIQLLVHGVGQAGPEITDELVRVLRRRLDEATLDIITVMLVRNCKLTPADVEFIQPPGSLPSEVLHLVLPPSCRPCLPALAWYLRQNLLTFLHSPKYTDSNSRNHFQHPLPAQGGLPDLDIYLYNKPGGQGTGGKGVACITLAFVEEGGTPISLASWPPSSPGPPDPLREEEFEQLTQVIRCPNTLDSCSAQDGSPRLRLDVWEKGNISIVQLEEKLRAAARQALADAIMELRLLPASLCTEDIPPGSLKSGPLDTKSPACRANTFPCTPVSGEPVTPPSKAGRRSFWDMLSKTEAGDLGSPKTTDDIVLDRPEDTRGRRRHKTENVRTPGGSERAPGPDSGAQRQRRRTTQLEEGEVGTLHPVFARVIQRWMGFMVQIGCASVSRSSTHMVSRFLLPSILSEFTTLVISMAGDTSVRVFEQHLGSEPDVFSPCSPGQLGPAPRPAAQRHLLLLGRNFAQWRRPTQQAAKAVQRFESGGDGSPGRSAPRQRLLLLEVTDKKLQLLTYNWAPDLGAALGRALIRLVQWQNARAHLISCLLSQKLGLFHHCGQLDFPMRDGKEPNPFLLPTMEVETLIRNASPPLSREQGRLSGSSRGGGPLSLDTFPFDEALRDITAARPSSTGGPAPRPPDPVTYHGQQFLEIKMTERKELERQMKMENLFVTWQQRSAPASMPISAGELETLKQSSRLVHYCATALLFDPAAWLHGPPETCAPSEGQRRPCPESGSGSREVPTSCESLDVPPPGAREEPWLKELSLAFLQQYVQYLQSIGFVLVPLRPPSPARSTSRLRAMAILGTEGRGSFSCPKAKAEGSPKSTSTPVTTYHLQRALPGGIILMELTFQGCYFCVKQFALECSRIPMGQAVNSQLSLLFTEECDKVRDLMHVHSFSYDFHLRLVHQHVLGAHLALRHGYHLTTFLQHFLAHHPDGPHFGRNHIYQGTLELPTPLIAAHQLYNYVADHASSYHMKPLRMARPGGPEHNEYALVSAWHSSGSYLDSEGLRHQDDFDVSLLVCHSAAPFEEQGEAERHVLRLQFFVVLTSQRELFPRLTADMRRFRKPSRLPLEPETPGSLVGSPREASGMMLAPGPAPLFPPLAAEVGMARARLAQLVRLAGGHCRRDTLWKRLFLLEPPGPDRLRLGGRLALAELEELLEAVHAKSIADIDPQLDCFLSMTVSWYQSLIKVLLSRFPQSCRHFQSPDLGTQYLVVLNQKFTDCFVLVFLDSHLGKTSLTVVFREPFPVQPQDSESPPAQLVSTYHHLESVINTACFTLWTRLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
215	Phosphorylation	QGQAEDQSPESGESL CCCCCCCCCCCCCCH	42.85	29899451
229	Phosphorylation	LGRKVGVSMVTADLG HHHHHCHHHHHCCHH	11.12	28285833
239	Phosphorylation	TADLGLVSMIRQGIL HCCHHHHHHHHHCHH	17.34	28285833
649	Phosphorylation	APDQPPSSFYMVRII CCCCCCCCEEEEEEE	26.60	28059163
699	Phosphorylation	RFPHRVQSKEPTPKV HCCCCCCCCCCCCCC	35.81	23684622
703	Phosphorylation	RVQSKEPTPKVKRKG CCCCCCCCCCCCCCC	36.51	23684622
717	Phosphorylation	GLGGVGGSSPSKSPP CCCCCCCCCCCCCCC	32.90	26643407
718	Phosphorylation	LGGVGGSSPSKSPPT CCCCCCCCCCCCCCC	36.15	26824392
720	Phosphorylation	GVGGSSPSKSPPTLG CCCCCCCCCCCCCCC	47.95	26643407
722	Phosphorylation	GGSSPSKSPPTLGPQ CCCCCCCCCCCCCHH	40.21	26643407
725	Phosphorylation	SPSKSPPTLGPQQAL CCCCCCCCCCHHHCC	47.97	26643407
733	Phosphorylation	LGPQQALSDRPCLVV CCHHHCCCCCCEEEE	34.29	26643407
754	Ubiquitination	KLLIRYEKLPLDYRA HHHHHHHCCCCCCCC	46.61	22790023
1112	Phosphorylation	VIPGVLRSSISAQPP EECCCHHHHHCCCCC	28.06	29472430
1113	Phosphorylation	IPGVLRSSISAQPPQ ECCCHHHHHCCCCCC	17.71	23140645
1115	Phosphorylation	GVLRSSISAQPPQWH CCHHHHHCCCCCCCC	23.85	25266776
1275	Phosphorylation	AQDLDHPSSSSAWME HHHCCCCCCCCCCCC	39.16	-
1385	Phosphorylation	RERAILVSESSIETE HHHEEEEECCCCCCC	28.46	25619855
1387	Phosphorylation	RAILVSESSIETEDL HEEEEECCCCCCCCC	29.16	25619855
1388	Phosphorylation	AILVSESSIETEDLS EEEEECCCCCCCCCC	22.01	25619855
1391	Phosphorylation	VSESSIETEDLSEPE EECCCCCCCCCCCCC	32.88	25619855
1395	Phosphorylation	SIETEDLSEPEFQSS CCCCCCCCCCCHHHC	64.52	25619855
1401	Phosphorylation	LSEPEFQSSRVSGNL CCCCCHHHCCCCCCC	25.98	25619855
1402	Phosphorylation	SEPEFQSSRVSGNLD CCCCHHHCCCCCCCC	26.39	25619855
1415	Phosphorylation	LDPGPEISLTDVCQL CCCCCCCCHHHHHHH	24.45	-
1639	Phosphorylation	SDPQHHRSTSESSAS CCCCCCCCCCCCCCC	31.74	29472430
1640	Phosphorylation	DPQHHRSTSESSASF CCCCCCCCCCCCCCC	36.15	24899341
1641	Phosphorylation	PQHHRSTSESSASFP CCCCCCCCCCCCCCC	36.41	21082442
1643	Phosphorylation	HHRSTSESSASFPRS CCCCCCCCCCCCCCC	30.85	24899341
1644	Phosphorylation	HRSTSESSASFPRSP CCCCCCCCCCCCCCC	24.71	30352176
1646	Phosphorylation	STSESSASFPRSPGQ CCCCCCCCCCCCCCC	37.42	25777480
1650	Phosphorylation	SSASFPRSPGQPSSL CCCCCCCCCCCCCCC	33.35	28066266
1655	Phosphorylation	PRSPGQPSSLRSDDG CCCCCCCCCCCCCCC	33.83	25777480
1656	Phosphorylation	RSPGQPSSLRSDDGL CCCCCCCCCCCCCCC	34.19	25777480
1659	Phosphorylation	GQPSSLRSDDGLGPP CCCCCCCCCCCCCCC	45.40	25338131
1716	Phosphorylation	RRGGIPQSPALHRAA HHCCCCCCHHHHHHH	13.54	25338131
1930	Phosphorylation	LQDRVEVYAHARSLS HHHHHHHHHHHHHCC	4.52	-
2001	Phosphorylation	RSETPFHSRQRAVLP HCCCCCCCCCCCCCC	30.41	-
2009	Phosphorylation	RQRAVLPSDDFAADE CCCCCCCCCCCCCCC	45.72	30635358
2056	Phosphorylation	SRLKMGPSMGVSRAI CCCCCCCCCHHHHHH	23.57	28059163
2060	Phosphorylation	MGPSMGVSRAIQALR CCCCCHHHHHHHHHH	15.40	-
2126	Phosphorylation	SRSQEPISSEDSVAP CCCCCCCCCCCCCCC	38.09	23140645
2127	Phosphorylation	RSQEPISSEDSVAPR CCCCCCCCCCCCCCC	46.25	23140645
2130	Phosphorylation	EPISSEDSVAPRSPL CCCCCCCCCCCCCCC	19.00	23140645
2135	Phosphorylation	EDSVAPRSPLDMASS CCCCCCCCCCHHCCC	28.84	25266776
2141	Phosphorylation	RSPLDMASSRSSDAV CCCCHHCCCCCCCCC	21.46	23140645
2142	Phosphorylation	SPLDMASSRSSDAVR CCCHHCCCCCCCCCC	27.00	23140645
2144	Phosphorylation	LDMASSRSSDAVRPV CHHCCCCCCCCCCCC	34.22	25338131
2280	Phosphorylation	PDLDIYLYNKPGGQG CCCEEEEECCCCCCC	12.27	26745281
2288	Phosphorylation	NKPGGQGTGGKGVAC CCCCCCCCCCCCEEE	34.57	26745281
2361	Acetylation	LRLDVWEKGNISIVQ EEEEEECCCCEEEEE	41.36	7630967
2372	Ubiquitination	SIVQLEEKLRAAARQ EEEEHHHHHHHHHHH	33.62	22790023
2372	Acetylation	SIVQLEEKLRAAARQ EEEEHHHHHHHHHHH	33.62	7630979
2421	Phosphorylation	SPACRANTFPCTPVS CCCCCCCCCCCCCCC	28.15	29514104
2425	Phosphorylation	RANTFPCTPVSGEPV CCCCCCCCCCCCCCC	27.28	25619855
2428	Phosphorylation	TFPCTPVSGEPVTPP CCCCCCCCCCCCCCC	38.35	25619855
2433	Phosphorylation	PVSGEPVTPPSKAGR CCCCCCCCCCCCCCC	39.95	25521595
2436	Phosphorylation	GEPVTPPSKAGRRSF CCCCCCCCCCCCHHH	36.02	25619855
2442	Phosphorylation	PSKAGRRSFWDMLSK CCCCCCHHHHHHHHC	29.36	-
2448	Phosphorylation	RSFWDMLSKTEAGDL HHHHHHHHCCCCCCC	30.78	-
2591	Phosphorylation	PDVFSPCSPGQLGPA CCCCCCCCCCCCCCC	35.13	-
2953	Phosphorylation	RAMAILGTEGRGSFS HEEHHHCCCCCCCCC	31.64	29514104
2958	Phosphorylation	LGTEGRGSFSCPKAK HCCCCCCCCCCCCCC	16.78	23684622
2960	Phosphorylation	TEGRGSFSCPKAKAE CCCCCCCCCCCCCCC	31.07	-
3165	Phosphorylation	HQDDFDVSLLVCHSA CCCCCCEEEEEEECC	20.17	-
3171	Phosphorylation	VSLLVCHSAAPFEEQ EEEEEEECCCCHHHC	22.46	-
3215	Phosphorylation	MRRFRKPSRLPLEPE HHHHCCCCCCCCCCC	49.86	26060331
3223	Phosphorylation	RLPLEPETPGSLVGS CCCCCCCCCCCCCCC	43.60	25777480
3226	Phosphorylation	LEPETPGSLVGSPRE CCCCCCCCCCCCCCC	22.53	26824392
3230	Phosphorylation	TPGSLVGSPREASGM CCCCCCCCCCCCCCC	17.19	27087446
3235	Phosphorylation	VGSPREASGMMLAPG CCCCCCCCCCEECCC	23.59	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
3230	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SZT2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SZT2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SZT2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.