COR1B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COR1B_MOUSE
• UniProt AC: Q9WUM3
• Protein Name: Coronin-1B
• Gene Name: Coro1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 484
• Subcellular Localization: Cytoplasm, cytoskeleton. Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers..
• Protein Description: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity)..
• Protein Sequence: MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFMVLPLNKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIITWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPEAALEAEDWVSGQDANPILISLREAYVPSKQRDLKVSRRNVLSDSRPASYSRSGASTATAVTDVPSGNLAGAGEAGKLEEVMQELRALRMLVKEQGERISRLEEQLGRMENGDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFRKVVRQ ------CCHHHHHHH	33.48	21844203
25	S-palmitoylation	QPVKNDQCYEDIRVS CCCCCCCCCCCEEEE	4.47	28526873
41	S-palmitoylation	VTWDSTFCAVNPKFL EEECCCEEECCCCEE	4.13	28526873
209	Phosphorylation	IIDPRRGTLVAEREK EECCCCCCEEEHHHH	19.08	18779572
303	Phosphorylation	EITDEPPYIHFLNTF EECCCCCEEEEEECC	20.11	-
321	Phosphorylation	EPQRGMGSMPKRGLE CCCCCCCCCCCCCCC	24.02	-
330	Phosphorylation	PKRGLEVSKCEIARF CCCCCCCCHHHHHHH	23.39	18779572
332	Glutathionylation	RGLEVSKCEIARFYK CCCCCCHHHHHHHHH	3.40	24333276
345	S-nitrosylation	YKLHERKCEPIVMTV HHHHHCCCEEEEEEC	10.61	20925432
345	S-nitrosocysteine	YKLHERKCEPIVMTV HHHHHCCCEEEEEEC	10.61	-
345	S-palmitoylation	YKLHERKCEPIVMTV HHHHHCCCEEEEEEC	10.61	28526873
399	Phosphorylation	LREAYVPSKQRDLKV EHHHHCCCCCCCCCC	31.23	24719451
400	Malonylation	REAYVPSKQRDLKVS HHHHCCCCCCCCCCH	43.19	26320211
407	Phosphorylation	KQRDLKVSRRNVLSD CCCCCCCHHHHHCCC	24.76	24719451
413	Phosphorylation	VSRRNVLSDSRPASY CHHHHHCCCCCCCCC	29.29	26824392
415	Phosphorylation	RRNVLSDSRPASYSR HHHHCCCCCCCCCCC	36.47	21082442
419	Phosphorylation	LSDSRPASYSRSGAS CCCCCCCCCCCCCCC	26.73	26824392
420	Phosphorylation	SDSRPASYSRSGAST CCCCCCCCCCCCCCC	15.37	25777480
421	Phosphorylation	DSRPASYSRSGASTA CCCCCCCCCCCCCCC	19.92	21082442
421	O-linked_Glycosylation	DSRPASYSRSGASTA CCCCCCCCCCCCCCC	19.92	22517741
423	Phosphorylation	RPASYSRSGASTATA CCCCCCCCCCCCCEE	32.54	25338131
463	Malonylation	RALRMLVKEQGERIS HHHHHHHHHHHHHHH	40.12	26320211
463	Ubiquitination	RALRMLVKEQGERIS HHHHHHHHHHHHHHH	40.12	-
470	Phosphorylation	KEQGERISRLEEQLG HHHHHHHHHHHHHHH	36.71	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COR1B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
2	S	Phosphorylation	Phosphorylation on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COR1B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of COR1B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.