RHG01_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHG01_MOUSE
• UniProt AC: Q5FWK3
• Protein Name: Rho GTPase-activating protein 1
• Gene Name: Arhgap1
• Organism: Mus musculus (Mouse).
• Sequence Length: 439
• Subcellular Localization: Cytoplasm.
• Protein Description: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity)..
• Protein Sequence: MDPLSELQDDLTLDDTSQALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPEPVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKSPGQDPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVEVTQQVLQTLPEENYQVLHFLTAFLVQISAHCDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSTDAQGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPLSELQ -------CCHHHHHC	12.35	-
27	Phosphorylation	LNQLKLASIDEKNWP HHHHHHHHCCCCCCC	40.80	25521595
31	Ubiquitination	KLASIDEKNWPSDEM HHHHCCCCCCCCCCC	61.64	-
35	Phosphorylation	IDEKNWPSDEMPDFP CCCCCCCCCCCCCCC	37.51	25521595
44	Phosphorylation	EMPDFPKSDDSKSSS CCCCCCCCCCCCCCC	47.06	24925903
47	Phosphorylation	DFPKSDDSKSSSPEP CCCCCCCCCCCCCCC	39.15	24925903
49	Phosphorylation	PKSDDSKSSSPEPVT CCCCCCCCCCCCCCC	39.75	25521595
50	Phosphorylation	KSDDSKSSSPEPVTH CCCCCCCCCCCCCCC	54.36	25521595
51	Phosphorylation	SDDSKSSSPEPVTHL CCCCCCCCCCCCCCC	40.13	24925903
56	Phosphorylation	SSSPEPVTHLKWDDP CCCCCCCCCCCCCCC	32.00	24925903
59	Acetylation	PEPVTHLKWDDPYYD CCCCCCCCCCCCCHH	40.76	23806337
64	Phosphorylation	HLKWDDPYYDIARHQ CCCCCCCCHHHHHHH	22.29	19737024
65	Phosphorylation	LKWDDPYYDIARHQI CCCCCCCHHHHHHHE	13.27	17947660
80	Acetylation	VEVAGDDKYGRKIIV EEECCCCCCCCEEEE	55.11	-
89	Phosphorylation	GRKIIVFSACRMPPS CCEEEEEEECCCCCH	18.63	24719451
212	Ubiquitination	GIPRQVLKYDDFLKS CCCHHHHCHHHHHHH	48.02	-
212	Acetylation	GIPRQVLKYDDFLKS CCCHHHHCHHHHHHH	48.02	23236377
223	Phosphorylation	FLKSTQKSPATAPKP HHHHCCCCCCCCCCC	15.22	26824392
226	Phosphorylation	STQKSPATAPKPMPP HCCCCCCCCCCCCCC	47.04	20531401
245	Phosphorylation	PNQQFGVSLQHLQEK CCCCCCEEHHHHHHH	23.77	20531401
253	Phosphorylation	LQHLQEKSPGQDPIP HHHHHHHCCCCCCCC	33.25	29233185
388	Phosphorylation	HCDQNKMTNTNLAVV HCCCCCCCCCCEEEE	40.27	25367039
390	Phosphorylation	DQNKMTNTNLAVVFG CCCCCCCCCEEEEEC	23.57	25367039
411	Ubiquitination	KDAAITLKAINPINT HCHHHHHHHCCCCHH	38.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHG01_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHG01_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHG01_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDEL1_MOUSE	Ndel1	physical	18331715
LIS1_MOUSE	Pafah1b1	physical	18331715
RAC1_MOUSE	Rac1	physical	14966113
CDC42_MOUSE	Cdc42	physical	14966113
RHOA_MOUSE	Rhoa	physical	14966113

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-65, AND MASSSPECTROMETRY.
PubMed: 17947660