FTO_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FTO_MOUSE
• UniProt AC: Q8BGW1
• Protein Name: Alpha-ketoglutarate-dependent dioxygenase FTO
• Gene Name: Fto
• Organism: Mus musculus (Mouse).
• Sequence Length: 502
• Subcellular Localization: Nucleus . Nucleus speckle.
• Protein Description: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation..
• Protein Sequence: MKRVQTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLVFREAGSIPEELHKEVPEAFLTLHKHGCLFRDVVRIQGKDVLTPVSRILIGDPGCTYKYLNTRLFTVPWPVKGCTVKYTEAEIAAACQTFLKLNDYLQVETIQALEELAVREKANEDAVPLCMAEFPRAGVGPSCDDEVDLKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGSEDESEDESSFEGRDPDTWHVGFKISWDIETPGLTIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILERCQLALQNVLNDSDDGDVSLKSFDPAVLKQGEEIHNEVEFEWLRQFWFQGNRYKLCTDWWCEPMTHLEGLWKKMESMTNAVLREVKREGLPVEQRSEILSAILVPLTVRQNLRKEWHARCQSRVVRTLPVQQKPDCRPYWEKDDPSMPLPFDLTDVVSELRGQLLEARS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Ubiquitination	DVVRIQGKDVLTPVS EEEEECCCCCEEECH	28.43	22790023
213	Acetylation	PQKMPYLKEEPYFGM CCCCCCCCCCCCCCC	54.94	-
213	Ubiquitination	PQKMPYLKEEPYFGM CCCCCCCCCCCCCCC	54.94	22790023
226	Phosphorylation	GMGKMAVSWHHDENL CCCCEECEECCCCCC	15.91	-
237	Phosphorylation	DENLVDRSAVAVYSY CCCCCCCCEEEEEEE	23.72	23984901
242	Phosphorylation	DRSAVAVYSYSCEGS CCCEEEEEEEECCCC	7.67	30635358
243	Phosphorylation	RSAVAVYSYSCEGSE CCEEEEEEEECCCCC	12.17	23984901
244	Phosphorylation	SAVAVYSYSCEGSED CEEEEEEEECCCCCC	10.31	23984901
245	Phosphorylation	AVAVYSYSCEGSEDE EEEEEEEECCCCCCC	10.35	19060867
249	Phosphorylation	YSYSCEGSEDESEDE EEEECCCCCCCCCCC	21.41	21183079
253	Phosphorylation	CEGSEDESEDESSFE CCCCCCCCCCCCCCC	63.77	27087446
257	Phosphorylation	EDESEDESSFEGRDP CCCCCCCCCCCCCCC	53.28	22817900
258	Phosphorylation	DESEDESSFEGRDPD CCCCCCCCCCCCCCC	25.85	23984901
266	Phosphorylation	FEGRDPDTWHVGFKI CCCCCCCCCEEEEEE	23.90	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
249	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
249	S	Phosphorylation	Kinase	GSK3B	Q9WV60	PSP
253	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
253	S	Phosphorylation	Kinase	GSK3B	Q9WV60	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FTO_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FTO_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FTO_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.