RRP44_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRP44_MOUSE
• UniProt AC: Q9CSH3
• Protein Name: Exosome complex exonuclease RRP44
• Gene Name: Dis3
• Organism: Mus musculus (Mouse).
• Sequence Length: 958
• Subcellular Localization: Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus . Predominantly located in the nucleus. According to, found in the nucleolus. According to, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of
• Protein Description: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities..
• Protein Sequence: MLRSKTFLKKTRAGGVVKIVREHYLRDDIGCGAPACSACGGAHAGPALELQPRDQASSLCPWPHYLLPDTNVLLHQIDVLEHPAIRNVIVLQTVMQEVRNRSAPIYKRIRDVTNNQEKHFYTFTNEHHKETYIEQEQGENANDRNDRAIRVAAKWYNEHLKRVAADSQLQVILITNDRKNKEKAVQEGIPAFTCEEYVKSLTANPELIDRLAYLSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQGIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNQLAKILKKGRIEKGALTLSSPEIRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYDILVKAAKSKNLQIKTDTAKSLADSLDRAESPDFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLSDICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPKPRLAYDDEIPSLRIEGTVFHVFDKVKVKITLDSSNLQHQKIRMALVEPQIPGINIPPNVADKALTAPGGKKRKLEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLRSKTFL -------CCCCHHHH	6.73	-
18	Acetylation	TRAGGVVKIVREHYL HCCCCCEEEEEHHHC	32.83	23806337
213	Phosphorylation	ELIDRLAYLSDEMNE HHHHHHHHHCHHHHH	16.01	28833060
215	Phosphorylation	IDRLAYLSDEMNEIE HHHHHHHCHHHHHHH	20.88	21082442
223	Phosphorylation	DEMNEIESGKIIFSE HHHHHHHCCCEEEEC	51.56	26745281
236	Ubiquitination	SEHLPLSKLQQGIKS ECCCCHHHHHHHHHC	58.98	22790023
242	Ubiquitination	SKLQQGIKSGSYLQG HHHHHHHHCCCHHHE	56.44	22790023
561	Phosphorylation	NVDRLAFSCIWEMNH CHHHHHHHHHHHCCC	10.09	30165576
633	Phosphorylation	EKGALTLSSPEIRFH CCCCEECCCCCEEEE	38.31	22006019
634	Phosphorylation	KGALTLSSPEIRFHM CCCEECCCCCEEEEC	29.66	26824392
730	Phosphorylation	DSLDRAESPDFPYLN HHHHHHHCCCCHHHH	28.87	26239621
922	Acetylation	SSNLQHQKIRMALVE CCCCCCCEEHHHHCC	30.10	23236377

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RRP44_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRP44_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRP44_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RRP44_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.