TIRR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIRR_MOUSE
• UniProt AC: Q8VHN8
• Protein Name: Tudor-interacting repair regulator protein {ECO:0000250|UniProtKB:Q9BRJ7}
• Gene Name: Nudt16l1 {ECO:0000312|MGI:MGI:1914161}
• Organism: Mus musculus (Mouse).
• Sequence Length: 211
• Subcellular Localization: Nucleus .
• Protein Description: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA..
• Protein Sequence: MSTTTVPELKQISREEAMRLGPGWSHSCHAMLYAANPGQLFGRIPMRFSVLMQMRFDGLLGFPGGFVDRRFWSLEDGLNRVLGLGLGGLRLTEADYLSSHLTEGPHRVVAHLYARQLTLEQLHAVEISAVHSRDHGLEVLGLVRVPLYTQKDRVGGFPNFLSNAFVSTAKYQLLFALKVLNMMPSEKLAEALASATEKQKKALEKLLPPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTTTVPEL ------CCCCCHHHH		23737553
3	Phosphorylation	-----MSTTTVPELK -----CCCCCHHHHH		23737553
4	Phosphorylation	----MSTTTVPELKQ ----CCCCCHHHHHH		23737553
5	Phosphorylation	---MSTTTVPELKQI ---CCCCCHHHHHHH		23737553
13	Phosphorylation	VPELKQISREEAMRL HHHHHHHCHHHHHHH		23737553
151	Ubiquitination	RVPLYTQKDRVGGFP EEEECCCCCCCCCCC		22790023
151 (in isoform 2)	Ubiquitination	-		22790023
162	Phosphorylation	GGFPNFLSNAFVSTA CCCCCHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIRR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIRR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIRR_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TIRR_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.