PXDN_MOUSE - dbPTM
PXDN_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PXDN_MOUSE
UniProt AC Q3UQ28
Protein Name Peroxidasin homolog
Gene Name Pxdn
Organism Mus musculus (Mouse).
Sequence Length 1475
Subcellular Localization Secreted, extracellular space, extracellular matrix . Enriched in the peritubular space of fibrotic kidneys.
Protein Description Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system (By similarity). Plays a role in extracellular matrix formation..
Protein Sequence MAVRPTRRCLLALLLCFAWWAMAVVASKQGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRSLNTLLLNNNQIKKIPNGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPESFQHLPKLERLFLHNNRITHLVPGTFSQLESMKRLRLDSNALHCDCEILWLADLLKTYAQSGNAQAAATCEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQEADEGVYQCMAKNVAGEAKTQEVTLRYLGSPARPTFVIQPQNTEVLVGESVTLECSATGHPLPQITWTRGDRTPLPIDPRVNITPSGGLYIQNVAQSDSGEYTCFASNSVDSIHATAFIIVQALPQFTVTPQSRVVIEGQTVDFQCAAKGHPQPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDMTVEVGTNVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGTADAGRYECVARNTIGYASVSMVLSVNVPDVSRNGDPYVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVGQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLSLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKAVYENGFNTPRGINSQRQYNGHVLPMPRLVSTTLIGTEVITPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSSVCSNDPPCFSVMIPPNDPRVRSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTDHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIAAELLKLNPHWDGDTVYHETRKIVGAEIQHITYRHWLPKILGEVGMKMLGEYRGYDPSVNAGIFNAFATAAFRFGHTLINPLLYRLDENFEPIPQGHVPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRIPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAYTFEDLKNEIKSPVIREKLQRLYGSTLNIDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRLRDGDRLWYENPGVFSPAQLTQLKQTSLARILCDNSDNITRVQQDVFRVAEFPHGYSSCEDIPRVDLRVWQDCCEDCRTRGQFNAFSYHFRGRRSLEFSYEDDKPTKRARWRKALSVKHGKHLSNATSATHEHLEGPATNDLKEFVLEMQKIITDLRKQINSLESRLSTTECVDDSGESHGGNTKWKKDPCTVCECKNGQITCFVEACQPAACPQPVKVEGACCPVCLKNTAEEKP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
150PhosphorylationIETLDPESFQHLPKL
CCCCCHHHHCCCHHH		35.2825338131
261PhosphorylationVTSGNTVYFTCRAEG
CCCCCEEEEEEECCC		7.3722871156
335PhosphorylationVTLRYLGSPARPTFV
EEEECCCCCCCCEEE		16.8823737553
596PhosphorylationYECVARNTIGYASVS
EEEEEECCCCEEEEE		15.3822817900
601PhosphorylationRNTIGYASVSMVLSV
ECCCCEEEEEEEEEE		13.2620415495
603PhosphorylationTIGYASVSMVLSVNV
CCCEEEEEEEEEEEC		10.7320415495
614PhosphorylationSVNVPDVSRNGDPYV
EEECCCCCCCCCCEE		27.66-
637N-linked_GlycosylationATVDRAINSTRTHLF
HHHHHHHHHCCCCCC		36.02-
638PhosphorylationTVDRAINSTRTHLFD
HHHHHHHHCCCCCCC		17.1028576409
639PhosphorylationVDRAINSTRTHLFDS
HHHHHHHCCCCCCCC		34.7928576409
696N-linked_GlycosylationHGLMVDLNGTSYHYN
CCCEEECCCCEEECC		47.43-
716N-linked_GlycosylationQYLSLIANLSGCTAH
HHHHHHHHHHCCCHH		27.96-
728N-linked_GlycosylationTAHRRVNNCSDMCFH
CHHHCCCCCCHHHCC		24.66-
839PhosphorylationALSQARFSDGQHCSS
HHHCCCCCCCCCCHH		34.9725777480
845PhosphorylationFSDGQHCSSVCSNDP
CCCCCCCHHHCCCCC		24.5525777480
846PhosphorylationSDGQHCSSVCSNDPP
CCCCCCHHHCCCCCC		32.3225777480
849PhosphorylationQHCSSVCSNDPPCFS
CCCHHHCCCCCCCEE		41.9525777480
856PhosphorylationSNDPPCFSVMIPPND
CCCCCCEEEECCCCC		19.9325777480
904PhosphorylationREQINQLTSYIDASN
HHHHHHHHHHHCHHH		15.1030635358
905PhosphorylationEQINQLTSYIDASNV
HHHHHHHHHHCHHHC		28.7830635358
906PhosphorylationQINQLTSYIDASNVY
HHHHHHHHHCHHHCC		9.5130635358
910PhosphorylationLTSYIDASNVYGSTD
HHHHHCHHHCCCCCC		24.0730635358
913PhosphorylationYIDASNVYGSTDHEA
HHCHHHCCCCCCHHH		15.0330635358
915PhosphorylationDASNVYGSTDHEARS
CHHHCCCCCCHHHHH		16.9930635358
916PhosphorylationASNVYGSTDHEARSI
HHHCCCCCCHHHHHH		36.6930635358
1173PhosphorylationPYHDYRVYCNLSAAY
CCCCEEEEEECCEEE		2.68-
1175N-linked_GlycosylationHDYRVYCNLSAAYTF
CCEEEEEECCEEEEH		21.24-
1177PhosphorylationYRVYCNLSAAYTFED
EEEEEECCEEEEHHH		9.25-
1228PhosphorylationPGSRLGPTLMCLLST
CCCCHHHHHHHHHHH		25.8922871156
1277N-linked_GlycosylationILCDNSDNITRVQQD
HHCCCCCCCCCHHHH		37.03-
1296PhosphorylationAEFPHGYSSCEDIPR
HCCCCCCCCCCCCCC		32.8626525534
1297PhosphorylationEFPHGYSSCEDIPRV
CCCCCCCCCCCCCCC		17.0326525534
1334PhosphorylationYHFRGRRSLEFSYED
EEECCCCEEECCCCC		30.78-
1364N-linked_GlycosylationKHGKHLSNATSATHE
HCCCCCCCCCHHCCH		54.31-
1415PhosphorylationTTECVDDSGESHGGN
CCEEECCCCCCCCCC		39.7428973931
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PXDN_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PXDN_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PXDN_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PXDN_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PXDN_MOUSE

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Related Literatures of Post-Translational Modification

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