INT1_MOUSE - dbPTM
INT1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INT1_MOUSE
UniProt AC Q6P4S8
Protein Name Integrator complex subunit 1
Gene Name Ints1
Organism Mus musculus (Mouse).
Sequence Length 2195
Subcellular Localization Nucleus membrane
Single-pass membrane protein .
Protein Description Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex..
Protein Sequence MNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQASESKTTSTLLKPAPSGLPSERKRDASASLSGTSALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIKEPSVVPIEVLPTVLLDEIEAAELEGNDDRIEGVLCGAVKQLKVTRAKPDSTLYLSLMYLAKIKPNIFATEGVIEALCSLLRRDASVNFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCRTFVDNIQTAFNTKMPPKSVLLQGEGARSGGELGAGSSPHPSLTEEEDSQTELLIAEEKLSPEQEGQLMPRPRYDELTESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTATCGYKEVRLLAVQRLEMWLQNPKLTRPAQDLLMSVCMNCNSHGSEDMDVISHLIKIRLKPKVLLNHYMLCIRELLNAHKDNLGTTIKFVIFNELSNARNPNNMQILYTVLQHSSELAPKFLAMVFQDLLTNKDDYLRASRALLREIIKQTKHEINFQAFCLGLMQERKEPQYLEMEFKERFVVHITDVLAVSMMLGITAQVKEAGVAWDKGEKRNLEVLRTFQNQIAAIQRDAVWWLHTVVPSVSKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCSEVPILEDTLMRVLVIGLSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVERIQLIDAVLNLCTYHHPENIQLPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTLKMLMEMVMTNNYSYPPCTLTDEETRTEMINRELQISQREKQEILAFEGHLAAASTKQTITESSSLLLSQLTSLDPQGPPRRPPPHILDQVKALNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLADLVQSSEGSLDVLPVQCLCEFLLHDAADSTASGEEDDEGESREQKAKKRQRQQKQRQLLGRLQDLLLGPKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGGLRDKEEKEPPMEEDIGETDALQGYQWLLRDLPRLPLFDSVRTTTALALQQAIHMETDPQTISAYLIYLSQHTPVEEQGPHSDLALDVARLVVERSTIMAHLFSKPSCSTASDAVLSALLSVFSRYVRRMRKSKEGEEVYSWSESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRSGDSEFSELLDIWFPEKKPLPTAFLVDTSEEALLLPDWLKLRMIRSEVPRLVDAALQDLEPQQLLLFVQSFGIPVSSMSKLLQYLDQAVAQDPQTLEQNIMDKNYMAHLVEVQHERGASGGQTFHSLLTASLPPRRDSTEAPKPESSPEPPPGQGRTRAGTQVPVLGPEDDLAGIFLQIFPLSPDPRWQSSSPRPLALALQQALGQELARVRQGNPEVPGITVRLLQAMTTLLSSPHGGTLALAMHHSHFLSCPLMRQLYQYQRAVPQDTGFSSLFLKVLMQILQWLDSPAVEDGPLQAQLKLFATRYSARHRISDVRSGLLHLADALSFHGDLEVANSTARAVIATLRSGEKCPVEPELISKVLRGLIEVRSPHLEELLTALFSATTETSCPSPASGPIVVVSSLLLQEKEELLGPSKQEVEGASTEAMRLGPASGLLVDWLETLDPEVVCSCPDLQWKLLFSRRKGKGHISAQVLSFRPYLLALLTHQASWSTLHCCIRVLLGKSREQRLDPSASLDFLWACIHVPRIWQGRDQRTPQKRREELVLHVQGPELLSLVELILSEAETRSQDGDSAARTLIQTRLPLLLSCCRSNDESIGKVTEHLTSCIQQWGDSVLGQRCRDLLLQLYLQRPEVRVPVPEVLLQSEGATSSSICKLDGLVHRFITLLADTSDSRSSESRVADANMACRKLAVAHPVLLLRHLPMIAALLHGRTHLNFQEFRQQNHLAFFLHVLGILELLQPRVFQSEHQGALWDCLRSFIRLLLNYRKSSRHLAPFISKFVQFIHKYVGCSAPAAVAFLQKHAEPLHDLSFDNSDLVMLKSLLAGLSLPSRDGRTDQGLDEEGEDERSAGSLPLVSVSLSTPLTVADVAPHMKRLSRGRAVEDVLETLSDIDEMSRRRPEVLGFFSTNLQRLMSSAEESCRNLAFSLALRSIQNNPSIAADFLPTFMYCLGSRDFEVVQTALRNLPEYTLLCQEHAAVLLHRAFLVGVYGQIDTSAQISEALKILHMEAVM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationPTTVRRPSAAAKPSG
CCCCCCCCCCCCCCC		28.8225266776
19PhosphorylationPSAAAKPSGHPPPGD
CCCCCCCCCCCCCCC		49.3729233185
47AcetylationKTTSTLLKPAPSGLP
CCCCCCCCCCCCCCC		42.1023806337
81PhosphorylationLTKRPKLSSTPPLSA
CCCCCCCCCCCCHHH		37.9928833060
82PhosphorylationTKRPKLSSTPPLSAL
CCCCCCCCCCCHHHH		56.2022942356
83PhosphorylationKRPKLSSTPPLSALG
CCCCCCCCCCHHHHH		26.0826824392
87PhosphorylationLSSTPPLSALGRLAE
CCCCCCHHHHHHHHH		27.5028833060
100AcetylationAEAAVAEKRAISPSI
HHHHHHHHHCCCCCC		37.0723806337
104PhosphorylationVAEKRAISPSIKEPS
HHHHHCCCCCCCCCC		16.1726824392
106PhosphorylationEKRAISPSIKEPSVV
HHHCCCCCCCCCCCE		39.2326239621
111PhosphorylationSPSIKEPSVVPIEVL
CCCCCCCCCEEEEEE		36.5226239621
275PhosphorylationLQGEGARSGGELGAG
ECCCCCCCCCCCCCC		51.0925293948
283PhosphorylationGGELGAGSSPHPSLT
CCCCCCCCCCCCCCC		39.9126643407
284PhosphorylationGELGAGSSPHPSLTE
CCCCCCCCCCCCCCC		26.7226643407
288PhosphorylationAGSSPHPSLTEEEDS
CCCCCCCCCCCCCCH		44.9126643407
290PhosphorylationSSPHPSLTEEEDSQT
CCCCCCCCCCCCHHH		45.7625293948
295PhosphorylationSLTEEEDSQTELLIA
CCCCCCCHHHEEEEE		42.1325293948
297PhosphorylationTEEEDSQTELLIAEE
CCCCCHHHEEEEEHH		32.3325293948
307PhosphorylationLIAEEKLSPEQEGQL
EEEHHCCCHHHCCCC		37.1427818261
497PhosphorylationKDDYLRASRALLREI
HHHHHHHHHHHHHHH		16.20-
579PhosphorylationRNLEVLRTFQNQIAA
CCHHHHHHHHHHHHH		25.9725619855
926PhosphorylationDAADSTASGEEDDEG
CCCCCCCCCCCCCHH		46.99-
942AcetylationSREQKAKKRQRQQKQ
HHHHHHHHHHHHHHH		59.637719029
984PhosphorylationFLRRLGSSQVASRVL
HHHHHCCHHHHHHHH		27.2029514104
988PhosphorylationLGSSQVASRVLAMKG
HCCHHHHHHHHHHHH		24.8629514104
1143PhosphorylationSKEGEEVYSWSESQD
CCCCCCCCCCCCCCC		14.0130635358
1144PhosphorylationKEGEEVYSWSESQDQ
CCCCCCCCCCCCCCE		29.3330635358
1146PhosphorylationGEEVYSWSESQDQVF
CCCCCCCCCCCCEEE		22.7930635358
1148PhosphorylationEVYSWSESQDQVFLR
CCCCCCCCCCEEEEE		33.2830635358
1259PhosphorylationSFGIPVSSMSKLLQY
HHCCCHHHHHHHHHH		27.5817242355
1260PhosphorylationFGIPVSSMSKLLQYL
HCCCHHHHHHHHHHH		2.9717242355
1308PhosphorylationSGGQTFHSLLTASLP
CCCCHHHHHHHCCCC		22.3827717184
1311PhosphorylationQTFHSLLTASLPPRR
CHHHHHHHCCCCCCC		21.3527717184
1313PhosphorylationFHSLLTASLPPRRDS
HHHHHHCCCCCCCCC		35.8527717184
1320PhosphorylationSLPPRRDSTEAPKPE
CCCCCCCCCCCCCCC		26.7425521595
1321PhosphorylationLPPRRDSTEAPKPES
CCCCCCCCCCCCCCC		40.2223684622
1328PhosphorylationTEAPKPESSPEPPPG
CCCCCCCCCCCCCCC		60.7727087446
1329PhosphorylationEAPKPESSPEPPPGQ
CCCCCCCCCCCCCCC		31.4625521595
1365PhosphorylationFLQIFPLSPDPRWQS
HHEECCCCCCCCCCC		27.7426824392
1660O-linked_GlycosylationHISAQVLSFRPYLLA
CEEEHHHHHHHHHHH		21.9830059200
1873UbiquitinationDANMACRKLAVAHPV
HHHHHHHHHHHHHHH		40.4522790023
2011PhosphorylationKSLLAGLSLPSRDGR
HHHHHCCCCCCCCCC		37.0028285833
2014PhosphorylationLAGLSLPSRDGRTDQ
HHCCCCCCCCCCCCC		48.5828285833
2032PhosphorylationEEGEDERSAGSLPLV
CCCCCHHCCCCCCEE		34.6328059163
2038PhosphorylationRSAGSLPLVSVSLST
HCCCCCCEEEEECCC		5.6324719451
2048PhosphorylationVSLSTPLTVADVAPH
EECCCCCCHHHHHHH		18.1728059163
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INT1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INT1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INT1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of INT1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INT1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1328 AND SER-1329, ANDMASS SPECTROMETRY.

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