WDR46_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR46_MOUSE
• UniProt AC: Q9Z0H1
• Protein Name: WD repeat-containing protein 46
• Gene Name: Wdr46
• Organism: Mus musculus (Mouse).
• Sequence Length: 622
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus..
• Protein Sequence: METAPKPGRGVPPKRDKPQAKRKKPRRYWEEETTPAAVATSPGPPRKKARTGESRPPRSKSAHIAQKSRFSKKPPISKTAPDWKKPQRTLSGAQDPFPGPVPAPLEEARKFCRIDKSKTLPHSKPKTQSKLEKAEAQEEEASVRAARAELLLAEEPGFLVGEDGEDTAKILQTDIVEAVDIASAAKHFDLNLRQFGPYRLNYSRTGRHLALGGRRGHVAALDWVTKKLMCEINVMEAVRDIHFLHSEALLAVAQNRWLYIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATTSETGFLTYLDVSVGKIVTALNVRAGRLSVMAQNPYNAVIHLGHSNGTVSLWSPAVKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRGTFQPLSSRTLPQGAGHLAFSQRGLLVAGMGDVVNIWAGQGKASPPSLEQPYLTHRLSGHVHGLQFCPFEDVLGVGHSGGFTSMLVPGAAEPNFDGLENNPYRSRKQRQEWEVKALLEKVPAELICLNPRALAEVDVVTLEQQKKERIERLGYDPDAKAAFQPKAKQKGRSSTASLVKRKKKVMDQEHRDKVRQSLEQQQQKKKQDMAMPPGARPSALDRFVRRAREGGLQVDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	RRYWEEETTPAAVAT CCCCCCCCCCCHHCC	41.16	27149854
34	Phosphorylation	RYWEEETTPAAVATS CCCCCCCCCCHHCCC	17.76	26643407
40	Phosphorylation	TTPAAVATSPGPPRK CCCCHHCCCCCCCCC	28.93	25159016
41	Phosphorylation	TPAAVATSPGPPRKK CCCHHCCCCCCCCCC	20.37	26824392
61	Phosphorylation	SRPPRSKSAHIAQKS CCCCCCHHHHHHHHH	26.73	26745281
89	Phosphorylation	DWKKPQRTLSGAQDP CCCCCCCCCCCCCCC	21.74	23970565
91	Phosphorylation	KKPQRTLSGAQDPFP CCCCCCCCCCCCCCC	31.31	25159016
142	Phosphorylation	EAQEEEASVRAARAE HHHHHHHHHHHHHHH	18.53	27566939
561	Phosphorylation	KQKGRSSTASLVKRK HHCCCCCHHHHHHHH	22.85	29176673
563	Phosphorylation	KGRSSTASLVKRKKK CCCCCHHHHHHHHHH	33.51	27149854
583	Phosphorylation	HRDKVRQSLEQQQQK HHHHHHHHHHHHHHH	24.25	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR46_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR46_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR46_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WDR46_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.