dbPTM

DDX24_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDX24_MOUSE
UniProt AC	Q9ESV0
Protein Name	ATP-dependent RNA helicase DDX24
Gene Name	Ddx24
Organism	Mus musculus (Mouse).
Sequence Length	857
Subcellular Localization
Protein Description	ATP-dependent RNA helicase..
Protein Sequence	MKVKETNSKPKLASRGTFQRKGIKIVGKWKQVTIDPNLFADGQMDDLVCFEELTDYRLVKNPSRLFSSEETKKRKAQAVSEEEEEEEGQSSSPKKKIKLKKQRDAARAAEGAAAQNEYEVKASEPEAQGEVTACSDQKVGGAKSESLAQAAPRKKKNKGKKKLDTFQSTSPKLPKKSKKTWMAEVHDQKADVSAWRDLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWHKMKAPPIPRSTGMPPREMRFGATAHLGSPCKDRTESGVLPEEARIETEAQPSDSGVQATPETSASASAQTLLVCDDDAGEGPSSLEEKPVPKQNEDGEEKFDAEQAGKLKQELCDQIAIYKVHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQYNPSRQTLVFSATLTLVHQAPARILHKKHVKKMDKTDKLDLLMQKVGMRGKPKVIDLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQYPGRSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLIGPEDVINFKKIYKTLQKDEDIPLFPVQSKYMDVVKERIRLARQIEKAEYRNFQACLHNSWIEQAAAALEIELEEEMYKGGKADQQEERRRQKQMKMLKQELRHLLSQPLFQENLKTRYPTQSGRPPQPVLASRNIESALSCLSRQKRRRKKPKEPRAPPQPGSSTS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	KNPSRLFSSEETKKR CCHHHCCCCHHHHHH	41.24	22942356
68	Phosphorylation	NPSRLFSSEETKKRK CHHHCCCCHHHHHHH	31.92	20139300
71	Phosphorylation	RLFSSEETKKRKAQA HCCCCHHHHHHHHHH	37.50	20139300
80	Phosphorylation	KRKAQAVSEEEEEEE HHHHHHCCHHHHHHC	42.16	27087446
90	Phosphorylation	EEEEEGQSSSPKKKI HHHHCCCCCCHHHHH	43.57	27087446
91	Phosphorylation	EEEEGQSSSPKKKIK HHHCCCCCCHHHHHC	42.65	23375375
92	Phosphorylation	EEEGQSSSPKKKIKL HHCCCCCCHHHHHCH	46.08	27087446
118	Phosphorylation	GAAAQNEYEVKASEP HHHHHCCEEECCCCC	33.31	25619855
123	Phosphorylation	NEYEVKASEPEAQGE CCEEECCCCCCCCCC	48.22	25619855
126	Phosphorylation	EVKASEPEAQGEVTA EECCCCCCCCCCEEE	49.96	24719451
132	Phosphorylation	PEAQGEVTACSDQKV CCCCCCEEECCCCCC	20.04	25619855
135	Phosphorylation	QGEVTACSDQKVGGA CCCEEECCCCCCCCC	40.38	25619855
165	Phosphorylation	KGKKKLDTFQSTSPK CCCCCCCCCCCCCCC	33.73	25619855
168	Phosphorylation	KKLDTFQSTSPKLPK CCCCCCCCCCCCCCC	27.02	25619855
169	Phosphorylation	KLDTFQSTSPKLPKK CCCCCCCCCCCCCCC	37.96	25521595
170	Phosphorylation	LDTFQSTSPKLPKKS CCCCCCCCCCCCCCC	25.86	25521595
214	Phosphorylation	ALSFLGFSAPTPIQA HHHHHCCCCCCHHHH	31.38	24704852
223	Phosphorylation	PTPIQALTLAPAIRD CCHHHHHHHHHHHHH	24.72	26239621
283	Phosphorylation	REMRFGATAHLGSPC HHHCCCCEEECCCCC	18.26	24068923
288	Phosphorylation	GATAHLGSPCKDRTE CCEEECCCCCCCCCC	33.22	27087446
294	Phosphorylation	GSPCKDRTESGVLPE CCCCCCCCCCCCCCH	44.64	24453211
296	Phosphorylation	PCKDRTESGVLPEEA CCCCCCCCCCCCHHH	33.32	25777480
444	Phosphorylation	HPEIVIATPGRLWEL CCCEEEECCHHHHHH	18.36	28066266
532	Phosphorylation	HVKKMDKTDKLDLLM HHHCCCCCCHHHHHH	33.82	22802335
854	Phosphorylation	RAPPQPGSSTS---- CCCCCCCCCCC----	36.81	23375375
855	Phosphorylation	APPQPGSSTS----- CCCCCCCCCC-----	38.29	29550500
856	Phosphorylation	PPQPGSSTS------ CCCCCCCCC------	39.90	27717184
857	Phosphorylation	PQPGSSTS------- CCCCCCCC-------	39.92	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDX24_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDX24_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDX24_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DDX24_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDX24_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.	17203969 [Abstract]