NID1_MOUSE - dbPTM
NID1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NID1_MOUSE
UniProt AC P10493
Protein Name Nidogen-1
Gene Name Nid1
Organism Mus musculus (Mouse).
Sequence Length 1245
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane.
Protein Description Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions..
Protein Sequence MLDASGCSWAMWTWALLQLLLLVGPGGCLNRQELFPFGPGQGDLELEAGDDVVSPSLELIGELSFYDRTDITSVYVTTNGIIAMSEPPATEYHPGTFPPSFGSVAPFLADLDTTDGLGNVYYREDLSPFIIQMAAEYVQRGFPEVSFQPTSVVVVTWESVAPYGGPSSSPAEEGKRNTFQAVLASSNSSSYAIFLYPEDGLQFFTTFSKKDESQVPAVVGFSKGLVGFLWKSNGAYNIFANDRESIENLAKSSNAGHQGVWVFEIGSPATAKGVVSADVNLDLDDDGADYEDEDYDLVTSHLGLEDVATPSPSHSPRRGYPDPHNVPRILSPGYEATERPRGVPTERTRSFQLPAERFPQHHPQVIDVDEVEETGVVFSYNTGSQQTCANNRHQCSVHAECRDYATGFCCRCVANYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVPVVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPIGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFLGHPGKLVLKQQFSGIDEHGHLTISTELEGRVPQIPYGASVHIEPYTELYHYSSSVITSSSTREYTVMEPDQDGAAPSHTHIYQWRQTITFQECAHDDARPALPSTQQLSVDSVFVLYNKEERILRYALSNSIGPVRDGSPDALQNPCYIGTHGCDSNAACRPGPGTQFTCECSIGFRGDGQTCYDIDECSEQPSRCGNHAVCNNLPGTFRCECVEGYHFSDRGTCVAAEDQRPINYCETGLHNCDIPQRAQCIYMGGSSYTCSCLPGFSGDGRACRDVDECQHSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCMPGEVSKTRCQLEREHILGAAGGADAQRPTLQGMFVPQCDEYGHYVPTQCHHSTGYCWCVDRDGRELEGSRTPPGMRPPCLSTVAPPIHQGPVVPTAVIPLPPGTHLLFAQTGKIERLPLERNTMKKTEAKAFLHIPAKVIIGLAFDCVDKVVYWTDISEPSIGRASLHGGEPTTIIRQDLGSPEGIALDHLGRTIFWTDSQLDRIEVAKMDGTQRRVLFDTGLVNPRGIVTDPVRGNLYWTDWNRDNPKIETSHMDGTNRRILAQDNLGLPNGLTFDAFSSQLCWVDAGTHRAECLNPAQPGRRKVLEGLQYPFAVTSYGKNLYYTDWKTNSVIAMDLAISKEMDTFHPHKQTRLYGITIALSQCPQGHNYCSVNNGGCTHLCLPTPGSRTCRCPDNTLGVDCIERK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77PhosphorylationDITSVYVTTNGIIAM
CCCEEEEECCCEEEE		9.25-
78PhosphorylationITSVYVTTNGIIAMS
CCEEEEECCCEEEEC		22.77-
187N-linked_GlycosylationQAVLASSNSSSYAIF
HHHHCCCCCCCEEEE		43.338326911
290SulfationLDDDGADYEDEDYDL
CCCCCCCCCCCCCCC		25.42-
290SulfationLDDDGADYEDEDYDL
CCCCCCCCCCCCCCC		25.42-
295SulfationADYEDEDYDLVTSHL
CCCCCCCCCCEECCC		14.77-
295SulfationADYEDEDYDLVTSHL
CCCCCCCCCCEECCC		14.77-
299O-linked_GlycosylationDEDYDLVTSHLGLED
CCCCCCEECCCCCCC		20.098326911
315PhosphorylationATPSPSHSPRRGYPD
CCCCCCCCCCCCCCC		25.1723384938
331O-linked_GlycosylationHNVPRILSPGYEATE
CCCCCCCCCCCCCCC		17.578326911
331PhosphorylationHNVPRILSPGYEATE
CCCCCCCCCCCCCCC		17.5722028470
337O-linked_GlycosylationLSPGYEATERPRGVP
CCCCCCCCCCCCCCC		22.168326911
345O-linked_GlycosylationERPRGVPTERTRSFQ
CCCCCCCCCCCCCCC		35.388326911
348O-linked_GlycosylationRGVPTERTRSFQLPA
CCCCCCCCCCCCCCH		25.168326911
415N-linked_GlycosylationFCCRCVANYTGNGRQ
CCCEEEEECCCCCCE		17.948326911
920O-linked_GlycosylationMRPPCLSTVAPPIHQ
CCCCCCCCCCCCCCC		14.038326911
933O-linked_GlycosylationHQGPVVPTAVIPLPP
CCCCCCCEEEEECCC		23.198326911
1162PhosphorylationTSYGKNLYYTDWKTN
ECCCCCCEECCCCCC		17.4522871156
1163PhosphorylationSYGKNLYYTDWKTNS
CCCCCCEECCCCCCC		11.0322871156
1164PhosphorylationYGKNLYYTDWKTNSV
CCCCCEECCCCCCCE		23.1022871156
1182SulfoxidationDLAISKEMDTFHPHK
EHHHCCCCCCCCCCC		7.2721406390
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
331SPhosphorylationKinaseMAPK1P63085
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NID1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NID1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NID1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NID1_MOUSE

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Structure and localization of O- and N-linked oligosaccharide chainson basement membrane protein nidogen.";
Fujiwara S., Shinkai H., Mann K., Timpl R.;
Matrix 13:215-222(1993).
Cited for: GLYCOSYLATION AT ASN-187; THR-299; SER-331; THR-337; THR-345; THR-348;ASN-415; THR-920 AND THR-933, AND PARTIAL PROTEIN SEQUENCE.
O-linked Glycosylation
ReferencePubMed
"Structure and localization of O- and N-linked oligosaccharide chainson basement membrane protein nidogen.";
Fujiwara S., Shinkai H., Mann K., Timpl R.;
Matrix 13:215-222(1993).
Cited for: GLYCOSYLATION AT ASN-187; THR-299; SER-331; THR-337; THR-345; THR-348;ASN-415; THR-920 AND THR-933, AND PARTIAL PROTEIN SEQUENCE.

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