DHX36_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHX36_MOUSE
• UniProt AC: Q8VHK9
• Protein Name: ATP-dependent RNA helicase DHX36
• Gene Name: Dhx36
• Organism: Mus musculus (Mouse).
• Sequence Length: 1001
• Subcellular Localization: Nucleus. Cytoplasm. Chromosome, telomere. Localizes to cytoplasmic stress granules..
• Protein Description: Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification..
• Protein Sequence: MSYDYHQSWSRDGGPRGSGQGSSGGGGGGSRGSGGGGGGRGGRGRHPAHLKGREIGLWYAKKQTQKNKEAERQERAVVHMDERREEQIVQLLNSVQAKTDKDSEAQISWFAPEDHGYGTEVSSEKKINSEKKLDNQEKKLLNQEKKTFRITDKSYIDRDSEYLLQENEPNLSLDQHLLEDLQRKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVATERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYVPDQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPAYIKELRTRYSASTVDVLQMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSNEAVVLSIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKETRSDHLTVVNAFEGWEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRSPKDPKANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKSDGLVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDKDQEIIAVDEWIVFQSPERIAHLVKGLRKELDSLLQEKIESPHPVDWDDTKSRDCAVLSAILDLIKTQEKATPRNLPPRSQDGYYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYDYHQSW ------CCCCCCCCC	37.71	26745281
3	Phosphorylation	-----MSYDYHQSWS -----CCCCCCCCCC	32.17	28066266
5	Phosphorylation	---MSYDYHQSWSRD ---CCCCCCCCCCCC	8.10	29514104
8	Phosphorylation	MSYDYHQSWSRDGGP CCCCCCCCCCCCCCC	17.44	26643407
10	Phosphorylation	YDYHQSWSRDGGPRG CCCCCCCCCCCCCCC	26.24	26643407
18	Phosphorylation	RDGGPRGSGQGSSGG CCCCCCCCCCCCCCC	29.26	29899451
59	Phosphorylation	GREIGLWYAKKQTQK CCHHHHHHHHHHCHH	17.37	29514104
138	Acetylation	KKLDNQEKKLLNQEK HHCCHHHHHHHHHHH	38.67	15620211
139	Acetylation	KLDNQEKKLLNQEKK HCCHHHHHHHHHHHC	58.41	15620219
145	Acetylation	KKLLNQEKKTFRITD HHHHHHHHCCEEECC	47.55	15620227
154	Phosphorylation	TFRITDKSYIDRDSE CEEECCHHHCCCCHH	30.08	-
261	Phosphorylation	CTQPRRISAISVAER ECCCCCEEEEEHHHH	20.10	25338131
276	Phosphorylation	VATERAESCGNGNST HHHHHHHHCCCCCCC	26.75	22006019
432	Phosphorylation	KEEKEAIYKERWPAY HHHHHHHHHHHHHHH	17.53	29514104
619	Phosphorylation	RASLLDDYQLPEILR HHHHCCCCCCHHHHC	16.18	22817900
763	Ubiquitination	FEGWEEAKRRGFRYE CCCHHHHHHCCCCCC	46.00	22790023
763	Ubiquitination	FEGWEEAKRRGFRYE CCCHHHHHHCCCCCC	46.00	22790023
940	Acetylation	ERIAHLVKGLRKELD HHHHHHHHHHHHHHH	59.60	-
948	Phosphorylation	GLRKELDSLLQEKIE HHHHHHHHHHHHHCC	43.53	25159016
956	Phosphorylation	LLQEKIESPHPVDWD HHHHHCCCCCCCCCC	31.79	28066266
999	Phosphorylation	PPRSQDGYYS----- CCCCCCCCCC-----	14.61	26643407
1000	Phosphorylation	PRSQDGYYS------ CCCCCCCCC------	17.27	26643407
1001	Phosphorylation	RSQDGYYS------- CCCCCCCC-------	25.84	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHX36_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHX36_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHX36_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DHX36_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.