PLPL6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPL6_MOUSE
• UniProt AC: Q3TRM4
• Protein Name: Neuropathy target esterase
• Gene Name: Pnpla6
• Organism: Mus musculus (Mouse).
• Sequence Length: 1355
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein ; Cytoplasmic side . Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
• Protein Description: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy..
• Protein Sequence: MGTPSHELNTTSSGAEVIQKTLEEGLGRRICVAQPVPFVPQVLGVMIGAGVAVLVTAVLILLVVRRLRVQKTPAPEGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSTTSRPRMKKKLKMLNIAKKILRIQKETPTLQRKEPPPSVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRVVSTSGTEDTSKETSGRPLDSIGAPLPGPAGDPVKPTSLEAPPAPLLSRCISMPVDISGLQGGPRSDFDMAYERGRISVSLQEEASGGPQTASPRELREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKRELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEEVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSHFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPGSGLSVPQHSELTNPASNLSTVAILPVCAEVPMMAFTLELQHALQAIGPTLLLNSDVIRALLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDTSLTPWTVRCLRQADCILIVGLGDQEPTVGQLEQMLENTAVRALKQLVLLHREEGPGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPSIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWTRGEVIEKMLTDRRSTDLNESRRADILAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEVEEEKSTLRQRRFLPQETPSSVADA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	N-linked_Glycosylation	GTPSHELNTTSSGAE CCCCCCCCCCCCHHH	38.02	-
104	Phosphorylation	RKVSQSTSSLVDTSV HHHHHCCCCCCCCCC	27.24	29899451
338	Phosphorylation	QPLRLFPSPGLPTRT CCCCCCCCCCCCCCC	25.02	24925903
343	Phosphorylation	FPSPGLPTRTSPVRG CCCCCCCCCCCCCCC	52.18	26239621
345	Phosphorylation	SPGLPTRTSPVRGSK CCCCCCCCCCCCCCC	39.60	26239621
346	Phosphorylation	PGLPTRTSPVRGSKR CCCCCCCCCCCCCCE	20.36	25521595
356	Phosphorylation	RGSKRVVSTSGTEDT CCCCEEEECCCCCCC	17.63	25521595
357	Phosphorylation	GSKRVVSTSGTEDTS CCCEEEECCCCCCCC	21.40	28066266
358	Phosphorylation	SKRVVSTSGTEDTSK CCEEEECCCCCCCCC	35.89	28066266
360	Phosphorylation	RVVSTSGTEDTSKET EEEECCCCCCCCCCC	30.38	28066266
373	Phosphorylation	ETSGRPLDSIGAPLP CCCCCCCCCCCCCCC	40.67	24719451
405	Phosphorylation	PLLSRCISMPVDISG CHHHHHHCCCCCCCC	22.21	25521595
417 (in isoform 3)	Phosphorylation	-	39.15	26824392
446	Phosphorylation	SGGPQTASPRELREQ CCCCCCCCHHHHHHC	28.07	26643407
691	Phosphorylation	LTRQPRATTVHAVRD HHCCCCCEEEEEECC	30.54	28576409
692	Phosphorylation	TRQPRATTVHAVRDT HCCCCCEEEEEECCC	14.87	28576409
699	Phosphorylation	TVHAVRDTELAKLPE EEEEECCCHHHCCCC	23.49	28576409
925	Phosphorylation	RRLFSRRSPAKLHEL HHHHHCCCHHHHHHH	28.26	-
933	Phosphorylation	PAKLHELYEKVFSRR HHHHHHHHHHHHHHH	15.66	-
1093	Phosphorylation	LWRYVRASMTLSGYL HHHHHHHCEECCCCC	11.18	22871156
1172	Ubiquitination	NPWADKVKVPDMAEI CCCCCCCCCCCHHHH	54.51	22790023
1289	Phosphorylation	EPPTSYVSDGCADGE CCCCCCCCCCCCCCC	21.76	-
1298	Phosphorylation	GCADGEESDCLTEYE CCCCCCCCCCCCCCH	29.35	25195567
1319	Phosphorylation	CSRDEGGSPEGASPS CCCCCCCCCCCCCCC	30.54	25521595
1324	Phosphorylation	GGSPEGASPSTASEV CCCCCCCCCCCHHHH	30.18	23684622
1329	Phosphorylation	GASPSTASEVEEEKS CCCCCCHHHHHHHHH	42.11	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPL6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPL6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPL6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLPL6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.