RL27A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL27A_MOUSE
• UniProt AC: P14115
• Protein Name: 60S ribosomal protein L27a
• Gene Name: Rpl27a
• Organism: Mus musculus (Mouse).
• Sequence Length: 148
• Protein Sequence: MPSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKVGMRHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGVAPIIDVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKGVGGACVLVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Hydroxylation	RGNAGGMHHHRINFD CCCCCCCCCCCCCCC	19.51	-
47	Acetylation	HHRINFDKYHPGYFG CCCCCCCCCCCCCCC	41.12	23201123
48	Phosphorylation	HRINFDKYHPGYFGK CCCCCCCCCCCCCCC	18.32	29514104
52	Phosphorylation	FDKYHPGYFGKVGMR CCCCCCCCCCCCCCC	17.38	25367039
55	Acetylation	YHPGYFGKVGMRHYH CCCCCCCCCCCCCCC	26.22	22826441
61	Phosphorylation	GKVGMRHYHLKRNQS CCCCCCCCCCCCCCC	9.85	29514104
68	Phosphorylation	YHLKRNQSFCPTVNL CCCCCCCCCCCCCCH	32.15	26824392
72	Phosphorylation	RNQSFCPTVNLDKLW CCCCCCCCCCHHHHH	24.17	28725479
77	Ubiquitination	CPTVNLDKLWTLVSE CCCCCHHHHHHHHCH	49.44	-
80	Phosphorylation	VNLDKLWTLVSEQTR CCHHHHHHHHCHHHH	27.93	28066266
83	Phosphorylation	DKLWTLVSEQTRVNA HHHHHHHCHHHHHHH	27.40	28066266
86	Phosphorylation	WTLVSEQTRVNAAKN HHHHCHHHHHHHHHC	32.31	28066266
94	Succinylation	RVNAAKNKTGVAPII HHHHHHCCCCCCCHH	46.05	23806337
94	Malonylation	RVNAAKNKTGVAPII HHHHHHCCCCCCCHH	46.05	26320211
94	Ubiquitination	RVNAAKNKTGVAPII HHHHHHCCCCCCCHH	46.05	-
94	Acetylation	RVNAAKNKTGVAPII HHHHHHCCCCCCCHH	46.05	23806337
106	Phosphorylation	PIIDVVRSGYYKVLG CHHHHHHCCCEEECC	21.38	29514104
110	Acetylation	VVRSGYYKVLGKGKL HHHCCCEEECCCCCC	23.62	22826441
125	Ubiquitination	PKQPVIVKAKFFSRR CCCCEEEEEEECCHH	34.43	27667366
127	Ubiquitination	QPVIVKAKFFSRRAE CCEEEEEEECCHHHH	41.02	27667366
144	S-nitrosylation	IKGVGGACVLVA--- HCCCCCEEEEEC---	2.48	22178444

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL27A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
39	H	Hydroxylation	Hydroxylated on His-39 by MINA.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL27A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL27A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.