dbPTM

UBP48_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP48_MOUSE
UniProt AC	Q3V0C5
Protein Name	Ubiquitin carboxyl-terminal hydrolase 48
Gene Name	Usp48
Organism	Mus musculus (Mouse).
Sequence Length	1052
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites (By similarity)..
Protein Sequence	MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVCRRNCRGNPNCLVGIGEHIWLGEIDENSFHSIDDPNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYTKGDGIHGGKDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNVVQQQFCGEYAYVTVCNQCGRESKLVSKFYELELNIQGHKQLTDCISEFLKEERLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESLDMEPYVEHKGGSFVYELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLEPSKSQTRKPKCGKGTHCSRNAYMLVYRLQAQEKNHTMVQVPAFLQELVDRDNSKFEEWCVEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPIDNNACLCSHDKLHPDKISIMKRISEYAANIFYSRYGGGPRLTVKALCKDCVVERCRVLRLKNQLNEDYKAVNNLLKSTMKGDGFWVGKSSLRSWRQLALEQLDEQDGEAEQSNGKINGSTFNKDESKEEKKEEEEELNFNEDILCPHGELSISENERRLVSQEAWSKLQQYFPKAPEFPSYRECCSQCKILEREGEENEALHKMIANEQKTSLPNLFQDKNRPCLSNWPEDTDALYIVSHFFLDEWRKFVRKPARSAPVSSIGNAALLCPHGGLMFTFPSLTKEDSKLCQPLERREGGWPTAAHNNIALIWPSEWQMIQKLFVVDKVIKITRIEVGDVNPSQTQYISEPSLCPDCREGLLCQQQRDLREYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKEEAKPDGEKDPDFNQSNGSTKRQKTSQQGYVAYQKQVIRRSTRHRKVRGEKALLVSANQTLKELKIQIMHAFSVAPFDQNLSIDGKILNDDCATLGTLGVIPESVILLKADEPIADYAAMDDVMQVCMPEEGFKGTGLLGH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
170	Ubiquitination	IDPSGFVKALGLDTG CCCHHHHHHHCCCCC	35.32	-
196	Phosphorylation	FMSLLEDTLSKQKNP HHHHHHHHHHHCCCH	24.45	28576409
258	Ubiquitination	DCISEFLKEERLEGD HHHHHHHHHHCCCCC	63.95	-
394	Acetylation	EEDLEPSKSQTRKPK CCCCCCCCCCCCCCC	58.25	15626497
399	Acetylation	PSKSQTRKPKCGKGT CCCCCCCCCCCCCCC	52.82	15626507
401	Acetylation	KSQTRKPKCGKGTHC CCCCCCCCCCCCCCC	59.67	15626517
530	Phosphorylation	ISIMKRISEYAANIF HHHHHHHHHHHHHHH	28.70	24719451
532	Phosphorylation	IMKRISEYAANIFYS HHHHHHHHHHHHHHH	12.29	24719451
680 (in isoform 2)	Ubiquitination	-	67.67	22790023
680	Ubiquitination	KLQQYFPKAPEFPSY HHHHHCCCCCCCCCH	67.67	22790023
695	Ubiquitination	RECCSQCKILEREGE HHHHHHCCHHHHCCC	42.56	-
708 (in isoform 2)	Ubiquitination	-	25.37	-
896	Phosphorylation	NKKVMKDSAPELNVS CCCCCCCCCCCCCCC	39.96	26643407
903	Phosphorylation	SAPELNVSSSETEED CCCCCCCCCCCCHHH	27.37	27600695
904	Phosphorylation	APELNVSSSETEEDK CCCCCCCCCCCHHHH	28.10	29899451
905	Phosphorylation	PELNVSSSETEEDKE CCCCCCCCCCHHHHH	40.82	29899451
907	Phosphorylation	LNVSSSETEEDKEEA CCCCCCCCHHHHHHC	46.77	27600695
973	Acetylation	VSANQTLKELKIQIM EECCHHHHHHHHHHH	65.47	-
1045	Ubiquitination	CMPEEGFKGTGLLGH HCCCCCCCCCCCCCC	67.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBP48_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBP48_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP48_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of UBP48_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP48_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-904 AND SER-905, ANDMASS SPECTROMETRY.	19367708 [Abstract]