SYTC_MOUSE - dbPTM
SYTC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYTC_MOUSE
UniProt AC Q9D0R2
Protein Name Threonine--tRNA ligase, cytoplasmic
Gene Name Tars
Organism Mus musculus (Mouse).
Sequence Length 722
Subcellular Localization Cytoplasm.
Protein Description
Protein Sequence MSQEKASSPSGKMDGEKPVDASEEKRKEGGKKKSKDGGGDGGRAELNPWPEYINTRLDMYNKLKAEHDSILAEKAAKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVVAKVNKVVWDLDRPLETDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLETLCKKIIKEKQTFERLEVKKETLLEMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKTLKIHKNSSTYWEGKADMETLQRIYGISFPDPKLLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNTLMEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKEQFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEIWNQAEKQLENSLNEFGEKWELNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADTDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKASGTVNIRTRDNKVHGERTVEETVRRLQQLKQTRSKQAEEEF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSQEKASSP
------CCHHHCCCC		47.2326643407
5Malonylation---MSQEKASSPSGK
---CCHHHCCCCCCC		46.0326320211
7Phosphorylation-MSQEKASSPSGKMD
-CCHHHCCCCCCCCC		54.5821082442
8PhosphorylationMSQEKASSPSGKMDG
CCHHHCCCCCCCCCC		28.1326824392
10PhosphorylationQEKASSPSGKMDGEK
HHHCCCCCCCCCCCC		53.6622942356
17AcetylationSGKMDGEKPVDASEE
CCCCCCCCCCCCCHH		56.7323954790
22PhosphorylationGEKPVDASEEKRKEG
CCCCCCCCHHHHHCC		41.6523684622
62UbiquitinationTRLDMYNKLKAEHDS
HHHHHHHHHHHHHHH		33.6022790023
74AcetylationHDSILAEKAAKDSKP
HHHHHHHHHHCCCCC		48.3023954790
90UbiquitinationKVTLPDGKQVDAESW
EEECCCCCEECHHHH		55.3027667366
90AcetylationKVTLPDGKQVDAESW
EEECCCCCEECHHHH		55.3023236377
106GlutathionylationTTPYQIACGISQGLA
CCCHHHHHCCCCCCC		5.4824333276
212MalonylationCKKIIKEKQTFERLE
HHHHHHHHHHHHHHH		50.0326320211
230UbiquitinationETLLEMFKYNKFKCR
HHHHHHHHHCCCEEE		46.7522790023
230AcetylationETLLEMFKYNKFKCR
HHHHHHHHHCCCEEE		46.7522826441
242AcetylationKCRILNEKVNTPTTT
EEEECCCCCCCCCCE		39.4523806337
242UbiquitinationKCRILNEKVNTPTTT
EEEECCCCCCCCCCE		39.45-
242MalonylationKCRILNEKVNTPTTT
EEEECCCCCCCCCCE		39.4526320211
245PhosphorylationILNEKVNTPTTTVYR
ECCCCCCCCCCEEEE		25.6228066266
247PhosphorylationNEKVNTPTTTVYRCG
CCCCCCCCCEEEECC		32.8128066266
248PhosphorylationEKVNTPTTTVYRCGP
CCCCCCCCEEEECCC		18.5728066266
278MalonylationIKTLKIHKNSSTYWE
EEEEEEECCCCCCCC		63.1026320211
278UbiquitinationIKTLKIHKNSSTYWE
EEEEEEECCCCCCCC		63.10-
278AcetylationIKTLKIHKNSSTYWE
EEEEEEECCCCCCCC		63.1022826441
280PhosphorylationTLKIHKNSSTYWEGK
EEEEECCCCCCCCCC		28.9425521595
281PhosphorylationLKIHKNSSTYWEGKA
EEEECCCCCCCCCCC		34.6029472430
282PhosphorylationKIHKNSSTYWEGKAD
EEECCCCCCCCCCCC		32.2629472430
283PhosphorylationIHKNSSTYWEGKADM
EECCCCCCCCCCCCH		11.9229472430
287UbiquitinationSSTYWEGKADMETLQ
CCCCCCCCCCHHHHH		29.6922790023
297PhosphorylationMETLQRIYGISFPDP
HHHHHHHHCCCCCCH		15.5920469934
300PhosphorylationLQRIYGISFPDPKLL
HHHHHCCCCCCHHHH		26.7728833060
305UbiquitinationGISFPDPKLLKEWEK
CCCCCCHHHHHHHHH		74.0522790023
308MalonylationFPDPKLLKEWEKFQE
CCCHHHHHHHHHHHH		71.8226320211
308UbiquitinationFPDPKLLKEWEKFQE
CCCHHHHHHHHHHHH		71.82-
318MalonylationEKFQEEAKNRDHRKI
HHHHHHHHCCCHHHH		56.6526320211
338PhosphorylationLYFFHELSPGSCFFL
EEEEEECCCCCEEEE		24.9923984901
341PhosphorylationFHELSPGSCFFLPKG
EEECCCCCEEEECCC		15.9023984901
361PhosphorylationTLMEFIRSEYRKRGF
HHHHHHHHHHHHCCC		33.8823567750
445PhosphorylationVLHRNELSGALTGLT
EEEHHHHHHHHHHHH		18.8121743459
449PhosphorylationNELSGALTGLTRVRR
HHHHHHHHHHHHHEE		29.6128066266
452PhosphorylationSGALTGLTRVRRFQQ
HHHHHHHHHHEEHHH		28.5928066266
503AcetylationNLSTRPEKFLGDIEI
ECCCCCHHHHHCHHH		48.8823954790
548AcetylationPKIDIQIKDAIGRYH
CEEEEEEECCCCCEE		25.4023236377
635UbiquitinationTCDEYAQKVRQQFHD
CHHHHHHHHHHHHHH		31.0822790023
644AcetylationRQQFHDAKFMADTDL
HHHHHHHCCCCCCCC		41.5523806337
644MalonylationRQQFHDAKFMADTDL
HHHHHHHCCCCCCCC		41.5526320211
649PhosphorylationDAKFMADTDLDPGCT
HHCCCCCCCCCCCCC		28.9929514104
655S-nitrosylationDTDLDPGCTLNKKIR
CCCCCCCCCCCHHHH		4.8122178444
655GlutathionylationDTDLDPGCTLNKKIR
CCCCCCCCCCCHHHH		4.8124333276
656PhosphorylationTDLDPGCTLNKKIRN
CCCCCCCCCCHHHHH		39.0029514104
659AcetylationDPGCTLNKKIRNAQL
CCCCCCCHHHHHHHH		53.3323864654
659MalonylationDPGCTLNKKIRNAQL
CCCCCCCHHHHHHHH		53.3326320211
711AcetylationVRRLQQLKQTRSKQA
HHHHHHHHHHHHHHH		45.3322826441
711MalonylationVRRLQQLKQTRSKQA
HHHHHHHHHHHHHHH		45.3326320211
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYTC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYTC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYTC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SYTC_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYTC_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-297, AND MASSSPECTROMETRY.

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