SCFD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCFD1_MOUSE
• UniProt AC: Q8BRF7
• Protein Name: Sec1 family domain-containing protein 1
• Gene Name: Scfd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 639
• Subcellular Localization: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
• Protein Description: Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)..
• Protein Sequence: MVGSKMAATASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRLCQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDPLGTGQFSFQRPLLVLVDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESTGVENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDVISDPDAGTPEDKMRLFLIYYISAQQAPSEVDLEQYKKALTDAGCNLSPLQYIKQWKAFAKMASTPASYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRSNDSSVPRNKSPFQEAIVFVVGGGNYIEYQNLVDYIKAKQGKHILYGCSEIFNATQFIKQLSQLGQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	NVPHVKNSTGEPVWK CCCCCCCCCCCCEEE	31.88	-
294	Phosphorylation	NRVNLEESTGVENSP HCCCCHHHCCCCCCC	22.53	27742792
295	Phosphorylation	RVNLEESTGVENSPA CCCCHHHCCCCCCCC	48.83	27742792
300 (in isoform 3)	Phosphorylation	-	11.56	19144319
300	Phosphorylation	ESTGVENSPAGARPK HHCCCCCCCCCCCCC	11.56	27087446
313	Phosphorylation	PKRKNKKSYDLTPVD CCCCCCCCCCCCCHH	26.03	28507225
321	Ubiquitination	YDLTPVDKFWQKHKG CCCCCHHHHHHHHCC	49.05	22790023
327	Ubiquitination	DKFWQKHKGSPFPEV HHHHHHHCCCCCHHH	69.03	22790023
381	Phosphorylation	DNTAKLTSAVSSLPE CCHHHHHHHHHCHHH	36.79	25338131
392	Ubiquitination	SLPELLEKKRLIDLH CHHHHHHHCCCHHCH	43.07	22790023
478	Phosphorylation	EQYKKALTDAGCNLS HHHHHHHHHCCCCCC	28.76	22418434
485	Phosphorylation	TDAGCNLSPLQYIKQ HHCCCCCCHHHHHHH	15.01	22418434
489	Phosphorylation	CNLSPLQYIKQWKAF CCCCHHHHHHHHHHH	20.12	22418434
491	Ubiquitination	LSPLQYIKQWKAFAK CCHHHHHHHHHHHHH	45.21	22790023
498	Ubiquitination	KQWKAFAKMASTPAS HHHHHHHHHHCCCHH	28.66	22790023
512	Ubiquitination	SYGNTTTKPMGLLSR HHCCCCCCCCCHHHH	30.80	22790023
523	Phosphorylation	LLSRVMNTGSQFVME HHHHHHHCCCHHHHH	21.80	22324799
525	Phosphorylation	SRVMNTGSQFVMEGV HHHHHCCCHHHHHHH	20.57	22324799
533	Ubiquitination	QFVMEGVKNLVLKQQ HHHHHHHHHHHHHCC	56.26	22790023
538	Ubiquitination	GVKNLVLKQQNLPVT HHHHHHHHCCCCCHH	42.21	-
538	Malonylation	GVKNLVLKQQNLPVT HHHHHHHHCCCCCHH	42.21	26320211
555	Ubiquitination	LDNLMEMKSNPETDD HHHHHHHHCCCCCCC	33.50	22790023
573	Phosphorylation	FDPKMLRSNDSSVPR CCHHHHCCCCCCCCC	40.81	25338131
634	Phosphorylation	TQFIKQLSQLGQK-- HHHHHHHHHHCCC--	22.36	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCFD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCFD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCFD1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SCFD1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.