GCSP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCSP_MOUSE
• UniProt AC: Q91W43
• Protein Name: Glycine dehydrogenase (decarboxylating), mitochondrial {ECO:0000305}
• Gene Name: Gldc {ECO:0000312|MGI:MGI:1341155}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1025
• Subcellular Localization: Mitochondrion .
• Protein Description: The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity)..
• Protein Sequence: MQLCARAWGLRLGRGAGGGHRLARGTGLSWAQRSRDSSGGGGGGGGGDRGAAGASRLLERLLPRHDDFSRRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRLKRPLKMEDPICENEILETLHAIASKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHNKRKKFFVDPRCHPQTIAVVQTRAKYRGVLVELKLPHEMDFSGKDVCGVLFQYPDTEGKVEDFTELVDRAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLKVQCGCSVKEVLGRAAQRQINFRLFDDGTLGISLDETVTEKDLDDLLWIFGCESSAELVAEGMGEERRGLLGSSFKRTSPFLTHQVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWREFANIHPFVPLDQAQGYQQLFQGLEKDLCEITGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRYGNIDVAHLKAMVDQHKENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLSPFLPSHPVISIKPTEGTWPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKEATEIAILNANYMAKRLEKHYRVLFRGARGYVAHEFILDTRPFKKSANVEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSCWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Acetylation	RHIGPGDKDRREMLQ CCCCCCCHHHHHHHH	60.08	23864654
91	Phosphorylation	LQALGLASIDELIEK HHHHCCCCHHHHHHH	35.30	23984901
99	Phosphorylation	IDELIEKTVPASIRL HHHHHHHHCCCCCCC	20.94	27180971
111	Acetylation	IRLKRPLKMEDPICE CCCCCCCCCCCCCCH	42.81	23864654
146	S-palmitoylation	IGMGYYNCSVPQTIL CCCCCCCCCCCHHHH	2.22	28526873
230	S-palmitoylation	KFFVDPRCHPQTIAV CEECCCCCCCCEEEE	7.17	26165157
230	S-nitrosylation	KFFVDPRCHPQTIAV CEECCCCCCCCEEEE	7.17	22178444
265	S-palmitoylation	DFSGKDVCGVLFQYP CCCCCEEEEEEEECC	4.47	28526873
342	Acetylation	HAAFFAVKENLVRMM HHHHHHHHHHHHHHC	37.14	23201123
414	Acetylation	QGLKHIAKRVHNATL HHHHHHHHHHHHHHH	55.11	23201123
452	Acetylation	VQCGCSVKEVLGRAA HHCCCCHHHHHHHHH	26.30	23576753
519	Malonylation	GLLGSSFKRTSPFLT CCCCCCCCCCCCCCC	57.63	26320211
519	Acetylation	GLLGSSFKRTSPFLT CCCCCCCCCCCCCCC	57.63	23576753
519	Ubiquitination	GLLGSSFKRTSPFLT CCCCCCCCCCCCCCC	57.63	-
608	S-palmitoylation	QGLEKDLCEITGYDR HHHHHHHHHHCCCEE	5.22	28526873
641	Ubiquitination	IRAYLDQKGERHRTV HHHHHHCCCCEECEE	63.51	22790023
641	Acetylation	IRAYLDQKGERHRTV HHHHHHCCCCEECEE	63.51	23864654
653	Acetylation	RTVCLIPKSAHGTNP CEEEEEECCCCCCCH	53.96	23576753
669	Acetylation	SAHMAGMKIQPVEVD HHHHCCCCEECEEEE	36.95	23576753
669	Succinylation	SAHMAGMKIQPVEVD HHHHCCCCEECEEEE	36.95	23954790
687	Acetylation	NIDVAHLKAMVDQHK CCCHHHHHHHHHHHH	25.27	23864654
759	Other	VSHLNLHKTFCIPHG CCEEEECCEEEECCC	46.60	-
759	N6-(pyridoxal phosphate)lysine	VSHLNLHKTFCIPHG CCEEEECCEEEECCC	46.60	-
762	S-nitrosylation	LNLHKTFCIPHGGGG EEECCEEEECCCCCC	5.98	22178444
832	Acetylation	MMGGKGLKEATEIAI HHCCCCHHHHHHHHH	54.71	23201123
832	Ubiquitination	MMGGKGLKEATEIAI HHCCCCHHHHHHHHH	54.71	22790023
847	Acetylation	LNANYMAKRLEKHYR HCHHHHHHHHHHHHH	40.77	23864654
847	Succinylation	LNANYMAKRLEKHYR HCHHHHHHHHHHHHH	40.77	23954790
876	Acetylation	ILDTRPFKKSANVEA HCCCCCCCCCCCCEE	48.80	23864654
877	Malonylation	LDTRPFKKSANVEAV CCCCCCCCCCCCEEE	56.00	26320211
877	Ubiquitination	LDTRPFKKSANVEAV CCCCCCCCCCCCEEE	56.00	-
877	Glutarylation	LDTRPFKKSANVEAV CCCCCCCCCCCCEEE	56.00	24703693
877	Acetylation	LDTRPFKKSANVEAV CCCCCCCCCCCCEEE	56.00	7628013
925	S-palmitoylation	KAELDRFCDAMISIR HHHHHHHHHHHHHHH	3.21	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCSP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCSP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCSP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GCSP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.