AMPB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AMPB_MOUSE
• UniProt AC: Q8VCT3
• Protein Name: Aminopeptidase B
• Gene Name: Rnpep
• Organism: Mus musculus (Mouse).
• Sequence Length: 650
• Subcellular Localization: Secreted.
• Protein Description: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)..
• Protein Sequence: MESGGPGNYSAAARRPLHSAQAVDVASASSFRAFEILHLHLDLRAEFGPPGPGPGSRGLSGTATLELRCLLPEGASELRLDSHSCLEVTAATLRRGQPGDQQAPAEPVPFHTQPFSHYGQALCVAFRQPCGAADRFELELTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALIEVPDGFTAVMSADTWEKRGPNKFFFQMSHPIPSYLIALAIGDLASAEVGPRSRVWAEPCLIEAAKEEYSGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMNVSGEENPLNKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQDQFDKFLKAYVDEFKFQSILAEDFLEFYLEYFPELKKKGVDSIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAELWVTSEPDMQAIEAVAISTWKTYQLVYFLDKILQKSPLPPGNVKKLGETYPKISNAQNAELRLRWGQIILKNDYQEEFQKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKDTFAATASQLHSNVVNYVQQILAPKDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESGGPGNYS -----CCCCCCCCCC	47.99	30635358
60	Phosphorylation	GPGSRGLSGTATLEL CCCCCCCCCCEEEEE	36.60	25159016
62	Phosphorylation	GSRGLSGTATLELRC CCCCCCCCEEEEEEE	17.06	25159016
64	Phosphorylation	RGLSGTATLELRCLL CCCCCCEEEEEEEEC	22.17	25159016
85	Glutathionylation	LRLDSHSCLEVTAAT CEECCCCCEEHHHHH	2.92	24333276
151	S-nitrosocysteine	VGEGPGVCWLAPEQT CCCCCCEEEECCCCC	2.82	-
151	S-nitrosylation	VGEGPGVCWLAPEQT CCCCCCEEEECCCCC	2.82	21278135
162	Acetylation	PEQTAGKKKPFVYTQ CCCCCCCCCCCEEEC	65.84	22826441
181	S-nitrosocysteine	LNRAFFPCFDTPAVK HHHHHCCCCCCCCCC	3.99	-
181	S-nitrosylation	LNRAFFPCFDTPAVK HHHHHCCCCCCCCCC	3.99	21278135
398	Ubiquitination	PLNKLRVKIEPGVDP CCCCCEEEEECCCCC	34.61	22790023
408	Phosphorylation	PGVDPDDTYNETPYE CCCCCCCCCCCCCCC	35.31	30635358
409	Phosphorylation	GVDPDDTYNETPYEK CCCCCCCCCCCCCCC	20.28	26026062
412	Phosphorylation	PDDTYNETPYEKGYC CCCCCCCCCCCCCCC	27.77	30635358
414	Phosphorylation	DTYNETPYEKGYCFV CCCCCCCCCCCCCHH	37.38	25195567
446	Acetylation	KAYVDEFKFQSILAE HHHHHHHCHHHHHHH	40.21	-
581	Ubiquitination	RWGQIILKNDYQEEF HHHEEEECCCHHHHH	37.05	-
592	Ubiquitination	QEEFQKVKDFLQSQG HHHHHHHHHHHHHCC	50.20	22790023
600	Ubiquitination	DFLQSQGKQKYTLPL HHHHHCCCCCEEHHH	35.66	-
615	Phosphorylation	YHAMMGGSEMARTLA HHHHHCHHHHHHHHH	20.61	28059163
620	Phosphorylation	GGSEMARTLAKDTFA CHHHHHHHHHHHHHH	22.87	28059163
631	Phosphorylation	DTFAATASQLHSNVV HHHHHHHHHHHHHHH	28.99	22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AMPB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AMPB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AMPB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AMPB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.