SYAC_MOUSE - dbPTM
SYAC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYAC_MOUSE
UniProt AC Q8BGQ7
Protein Name Alanine--tRNA ligase, cytoplasmic {ECO:0000255|HAMAP-Rule:MF_03133}
Gene Name Aars
Organism Mus musculus (Mouse).
Sequence Length 968
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain..
Protein Sequence MDATLTAREIRERFINFFRRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPVERLYVTYFGGDEAAGLEPDLECRQIWQNLGLDEARILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNRESDGVLKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFMPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYSHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPEMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDCKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMNGFEEERRLAQLKSQGKGAGDEDLIMLDIYAIEELRAKGLEATDDSPKYNYQSDSSGSYVFECTVATVLALRREKMFVDEVVTGQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGNLKVGDQVRLFIDEPRRRPVMSNHTATHILNFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIVNGMIEAAKPVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPCGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKSETLKKSLSAMEAKVKAQTAPNKDVQREIADLGEALATAVIPQWQKDEQRETLKSLKKVMDDLDRASKADVQKRVLEKTKQLIDSNPNQPLVILEMESGASAKALNEALKLFKTHSPQTSAMLFTVDNEAGKITCLCQVPQNAANRGLKASEWVQQVSGLMDGKGGGKDMSAQATGKNVGCLQEALQLATSFAQLRLGDVKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDATLTAR
-------CCCCCCHH		7.74-
72PhosphorylationKLSRAANTQKCIRAG
HHHHHHHHHHHHHCC		25.3620139300
74UbiquitinationSRAANTQKCIRAGGK
HHHHHHHHHHHCCCC		29.59-
192PhosphorylationGPCSEIHYDRIGGRD
CCCCHHCCCCCCCCC		16.7522817900
231UbiquitinationRESDGVLKPLPKKSI
CCCCCCCEECCCCCC		41.94-
318PhosphorylationDGGRPDNTGRGYVLR
CCCCCCCCCHHHHHH		35.3228464351
384UbiquitinationEEEVQFLKTLSRGRR
HHHHHHHHHHHHHHH		49.02-
396MalonylationGRRILDRKIQSLGDC
HHHHHHHHCHHCCCC		44.7726320211
399PhosphorylationILDRKIQSLGDCKTI
HHHHHCHHCCCCCCC		37.4826824392
403GlutathionylationKIQSLGDCKTIPGDT
HCHHCCCCCCCCCCC		3.8824333276
481PhosphorylationRAKGLEATDDSPKYN
HHCCCCCCCCCCCCC		30.8529233185
484PhosphorylationGLEATDDSPKYNYQS
CCCCCCCCCCCCCCC		26.5472249115
555PhosphorylationLVKVDDSSEDKTEFT
EEECCCCCCCCCEEE		57.73-
558AcetylationVDDSSEDKTEFTVKN
CCCCCCCCCEEEEEC		46.0023954790
580PhosphorylationVLHIGTIYGNLKVGD
EEEEEEEECCEECCC		10.3722871156
625UbiquitinationVLGEADQKGSLVAPD
HHCCCCCCCCCCCCC		51.52-
641UbiquitinationLRFDFTAKGAMSTQQ
EECCEECCCCCCHHH		44.11-
747UbiquitinationVTEEAIAKGIRRIVA
ECHHHHHCCCHHHHH		49.08-
762AcetylationVTGAEAQKALRKSET
HCCHHHHHHHHCHHH		57.3423954790
775PhosphorylationETLKKSLSAMEAKVK
HHHHHHHHHHHHHHH		32.4328059163
789MalonylationKAQTAPNKDVQREIA
HHHCCCCHHHHHHHH		59.2126320211
820UbiquitinationDEQRETLKSLKKVMD
HHHHHHHHHHHHHHH		62.25-
846UbiquitinationKRVLEKTKQLIDSNP
HHHHHHHHHHHHCCC		54.92-
867PhosphorylationLEMESGASAKALNEA
EEECCCCCHHHHHHH		33.5525338131
876UbiquitinationKALNEALKLFKTHSP
HHHHHHHHHHHHCCC		59.95-
876MalonylationKALNEALKLFKTHSP
HHHHHHHHHHHHCCC		59.9526320211
876AcetylationKALNEALKLFKTHSP
HHHHHHHHHHHHCCC		59.9522826441
879UbiquitinationNEALKLFKTHSPQTS
HHHHHHHHHCCCCCC		56.62-
880PhosphorylationEALKLFKTHSPQTSA
HHHHHHHHCCCCCCE		21.9126643407
882PhosphorylationLKLFKTHSPQTSAML
HHHHHHCCCCCCEEE		24.7626643407
885PhosphorylationFKTHSPQTSAMLFTV
HHHCCCCCCEEEEEE		23.1026643407
901GlutathionylationNEAGKITCLCQVPQN
CCCCEEEEEEECCHH		3.9924333276
903S-nitrosocysteineAGKITCLCQVPQNAA
CCEEEEEEECCHHHH		4.11-
903S-nitrosylationAGKITCLCQVPQNAA
CCEEEEEEECCHHHH		4.1120925432
930AcetylationVSGLMDGKGGGKDMS
HHCCCCCCCCCCCCC		50.5523954790
930MalonylationVSGLMDGKGGGKDMS
HHCCCCCCCCCCCCC		50.5526320211
934MalonylationMDGKGGGKDMSAQAT
CCCCCCCCCCCHHHC		54.2426320211
947S-palmitoylationATGKNVGCLQEALQL
HCCCCCHHHHHHHHH		2.8628526873
956PhosphorylationQEALQLATSFAQLRL
HHHHHHHHHHHHHHH		32.7330352176
957PhosphorylationEALQLATSFAQLRLG
HHHHHHHHHHHHHHC		16.9930352176
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYAC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYAC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYAC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SYAC_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYAC_MOUSE

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Related Literatures of Post-Translational Modification

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