PEG3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEG3_MOUSE
• UniProt AC: Q3URU2
• Protein Name: Paternally-expressed gene 3 protein
• Gene Name: Peg3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1571
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Plays a role in regulating maternal behavior and offspring growth..
• Protein Sequence: MYHHEDDTNSDMNSDDDMSRSGRETPPPRPSHAFGSERDLERRGRSRDVEPRDRWPYTRNPRSRLPQRDLSLPVMSRPHFGLDRDDDRRSMDYESRSQDAESYQNVVELKEDKKPQNPIQDNLENYRKLLSLGVQLAEDDRHSHMTQGHSSRSKRTAYPSTSRGLKPMPEAKKPSHRRGICEDESSHGVIMEKFIKDVARNPKSGRARELNERPPPRFPRPNDNWKDSSSSRRESVIQERGYEGSAFRGGFRFNADLASRSRALERKRRYHFDSDERGSGHEHKSCVRKKPFECGAEMRQAMSMGNLNSPSFSESQSIDFGANPYVCDECGRQFSVISEFVEHQIMHTRENLYEYGESFIHSVAVNEVQKGQGGGKRFECKECGETFSRSAALAEHRQIHAREYLAECRDQEDEETIMPSPTFSELQKMYGKDKFYECKVCKETFLHSSALIEHQKIHGRGNSDDRDNERERERDRLRARAREQRERERERERERELGEPFLTCPNFNEFRKMYRKDKIYECKVCGESFLHLSSLREHQKIHTRGNPFENKSRMCEETFVPSQSLRRRQKTYREKLFDFNNARDALMGNSDSSEHQKNRSRRNFFEGRGFEKPFVESQKSHTITRPPENKDDDKPFTISVNPNDKLKFPIMENGSQGKSYERSVIHSLGSAEAQKSHGGLGFSKPRPVAESSTQSSSSIYYPRAHSGGNTYEGKEYKDSIIHSLPAPRPLKRHRANDHIQCDEGGESSIYIPDIINKGRKIPAREDAYEGSSSSNYHTPNVSRAEPPSLSGESHDSKQDVTFSVPSSSVREHQKARAKKKYIEPRNNETSVIHSLPFGELLAGHRRAKFFECQECGEAFARRSELIEHQKIHDRERPSGSRHYERSVIRSLAPSDPQTSYAQERFIQEQVRKFRAFGQRSTTSNNLSVQKIYAQETFNAEEPHDKETHGQKIHDKEPYGKEPSGKEPHGDEPQDKEPLDQEMRSEEPHDDKPHGQEPHDDKPHGQEPHDDKPHGQEPHGDEPHGQEPHGDEPHDKEPIDQEMRSEEPHSEESHGDEPHGEESHGQEKVEDATIQASVSEEHQKDDAGDAIYECQDCGLGFTDLNDLTSHQDTHSRKALVDSREYAHSEVHAHSVSEFEKKCSGEKLYECPKCGESFIHSSLLFEHQRVHEQDQLYSVKACDDAFIALLPVRPRRNCTVERNPAVSGSAIRCRQCGQGFIHSSALNEHMRQHRDNEIMEQSELSDEIFIQGLALTEYQGSETEEKLFECTICGECFFTAKQLGDHHTKVHKDEPYEYGPSYTHASFLTEPLRKHIPLYECKDCGQSFLDDTVIAERMVFHPEREGGSEIVAATAQEVEANVLIPQEVLRIQGSNAEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPDGEAEQPNGEAEQPNGDADEPDGAGIEDPEERADEPEEDVEEPEGDADEPDGADIEDPEEEGEDQEIEVEEPYYNCHECAETFASSSAFGEHLKSHASVIIFEPANAPGECSGYIERASTSAGGAEQADDKYFKCDVCGQLFNDRLSLARHQNSHTG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MYHHEDDTNSDMNSD CCCCCCCCCCCCCCC	49.28	24759943
10	Phosphorylation	HHEDDTNSDMNSDDD CCCCCCCCCCCCCCC	40.09	24759943
14	Phosphorylation	DTNSDMNSDDDMSRS CCCCCCCCCCCCCCC	35.46	21149613
19	Phosphorylation	MNSDDDMSRSGRETP CCCCCCCCCCCCCCC	30.23	24759943
21	Phosphorylation	SDDDMSRSGRETPPP CCCCCCCCCCCCCCC	34.59	22807455
25	Phosphorylation	MSRSGRETPPPRPSH CCCCCCCCCCCCCCC	39.47	24899341
36	Phosphorylation	RPSHAFGSERDLERR CCCCCCCCHHHHHHH	24.01	24719451
71	Phosphorylation	RLPQRDLSLPVMSRP CCCCCCCCCCCCCCC	34.61	22817900
76	Phosphorylation	DLSLPVMSRPHFGLD CCCCCCCCCCCCCCC	42.78	22817900
90	Phosphorylation	DRDDDRRSMDYESRS CCCCCHHHCCHHHHH	19.52	29899451
97	Phosphorylation	SMDYESRSQDAESYQ HCCHHHHHHCHHHHH	41.51	25619855
110	Ubiquitination	YQNVVELKEDKKPQN HHHHHHHCCCCCCCC	50.81	-
113	Ubiquitination	VVELKEDKKPQNPIQ HHHHCCCCCCCCCCH	68.40	-
114	Ubiquitination	VELKEDKKPQNPIQD HHHCCCCCCCCCCHH	65.25	-
128	Ubiquitination	DNLENYRKLLSLGVQ HHHHHHHHHHHHCCC	43.34	-
196	Ubiquitination	VIMEKFIKDVARNPK HHHHHHHHHHHHCCC	49.65	-
226	Ubiquitination	PRPNDNWKDSSSSRR CCCCCCCCCCCCHHH	54.72	-
248	Methylation	GYEGSAFRGGFRFNA CCCCCCCCCCCCCCH	44.00	30988801
289	Ubiquitination	EHKSCVRKKPFECGA CCHHHCCCCCCCCCH	44.38	-
290	Ubiquitination	HKSCVRKKPFECGAE CHHHCCCCCCCCCHH	44.36	-
335	Phosphorylation	DECGRQFSVISEFVE CCCCCCCHHHHHHHH	15.37	25293948
338	Phosphorylation	GRQFSVISEFVEHQI CCCCHHHHHHHHHHH	23.87	25293948
370	Ubiquitination	VAVNEVQKGQGGGKR HHHCCCCCCCCCCCC	59.38	-
376	Ubiquitination	QKGQGGGKRFECKEC CCCCCCCCCEEECCC	58.13	-
407	Ubiquitination	HAREYLAECRDQEDE HHHHHHHHCCCCCCC	27.73	27667366
420	Phosphorylation	DEETIMPSPTFSELQ CCCCCCCCCCHHHHH	21.13	25338131
463	Phosphorylation	KIHGRGNSDDRDNER CCCCCCCCCCCCCHH	43.65	29899451
468	Ubiquitination	GNSDDRDNERERERD CCCCCCCCHHHHHHH	51.63	27667366
533	Phosphorylation	GESFLHLSSLREHQK CCCEEEHHHHHHHHC	19.31	25159016
534	Phosphorylation	ESFLHLSSLREHQKI CCEEEHHHHHHHHCH	37.49	25159016
551	Ubiquitination	RGNPFENKSRMCEET CCCCCCCHHHCHHCC	32.04	22790023
575	Ubiquitination	RQKTYREKLFDFNNA HHHHHHHHHHCCCCH	45.51	22790023
597	Ubiquitination	SDSSEHQKNRSRRNF CCCHHHHHHHHHCCH	57.12	22790023
612	Ubiquitination	FEGRGFEKPFVESQK HCCCCCCCCCCCCCC	41.30	27667366
632	Ubiquitination	RPPENKDDDKPFTIS CCCCCCCCCCCCEEE	68.40	27667366
647	Ubiquitination	VNPNDKLKFPIMENG ECCCCCCCCCEECCC	55.63	22790023
658	Ubiquitination	MENGSQGKSYERSVI ECCCCCCCCCHHHHH	42.08	-
693	Ubiquitination	RPVAESSTQSSSSIY CCCCCCCCCCCCCCC	41.57	27667366
757	Ubiquitination	YIPDIINKGRKIPAR ECHHHHCCCCCCCCC	50.08	-
782	O-linked_Glycosylation	NYHTPNVSRAEPPSL CCCCCCCCCCCCCCC	32.20	30059200
797	Ubiquitination	SGESHDSKQDVTFSV CCCCCCCCCCEEEEC	57.48	-
900	Phosphorylation	PSDPQTSYAQERFIQ CCCCCCHHHHHHHHH	18.72	28285833
922	Phosphorylation	AFGQRSTTSNNLSVQ HHCCCCCCCCCCCEE	30.61	27841257
930	Ubiquitination	SNNLSVQKIYAQETF CCCCCEEEEEEECCC	35.21	22790023
958	Phosphorylation	KIHDKEPYGKEPSGK CCCCCCCCCCCCCCC	41.75	22871156
963	Phosphorylation	EPYGKEPSGKEPHGD CCCCCCCCCCCCCCC	64.68	22871156
1178	Ubiquitination	QDQLYSVKACDDAFI CCCCEEEEECCCCEE	37.04	-
1207	Phosphorylation	RNPAVSGSAIRCRQC CCCCCCCCEEEEEEC	17.02	25338131
1312	Ubiquitination	FLTEPLRKHIPLYEC HHCHHHHHCCCCEEC	54.27	-
1320	Ubiquitination	HIPLYECKDCGQSFL CCCCEECCCCCCCCC	44.08	-
1325	Phosphorylation	ECKDCGQSFLDDTVI ECCCCCCCCCCCHHE	17.04	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEG3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEG3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEG3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PEG3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.