MSH3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSH3_MOUSE
• UniProt AC: P13705
• Protein Name: DNA mismatch repair protein Msh3
• Gene Name: Msh3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1091
• Protein Description: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis (By similarity)..
• Protein Sequence: MPRGKSASGGSTAAGPGPGRQTVLSRFFRSAGSLRSSASSTEPAEKVTEGDSRKRSLGNGGPTKKKARKVPEKEEENISVASHHPEAKKCLRPRIVLKSLEKLKEFCCDSALPQNRVQTEALRERLEVLPRCTDFEDITLQRAKNAVLSEDSKSQANQKDSQFGPCPEVFQKTSDCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNKSSVFSRKLTALYTKSTLIGEDVNPLIRLDDSVNIDEVMTDTSTNYLLCIYEEKENIKDKKKGNLSVGVVGVQPATGEVVFDCFQDSASRLELETRISSLQPVELLLPSDLSEPTEMLIQRATNVSVRDDRIRVERMNNTYFEYSHAFQTVTEFYAREIVDSQGSQSLSGVINLEKPVICALAAVIRYLKEFNLEKMLSKPESFKQLSSGMEFMRINGTTLRNLEMVQNQTDMKTKGSLLWVLDHTKTSFGRRKLKNWVTQPLLKLREINARLDAVSDVLHSESSVFEQIENLLRKLPDVERGLCSIYHKKCSTQEFFLIVKSLCQLKSELQALMPAVNSHVQSDLLRALIVELLSPVEHYLKVLNGPAAKVGDKTELFKDLSDFPLIKKRKNEIQEVIHSIQMRLQEFRKILKLPSLQYVTVSGQEFMIEIKNSAVSCIPADWVKVGSTKAVSRFHPPFIVESYRRLNQLREQLVLDCNAEWLGFLENFGEHYHTLCKAVDHLATVDCIFSLAKVAKQGNYCRPTLQEEKKIIIKNGRHPMIDVLLGEQDQFVPNSTSLSDSERVMIITGPNMGGKSSYIKQVTLVTIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGRSTFMEQLTDTAEIIRRASPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKCYPEQVGNYHMGFLVNEDESKQDSGDMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSKELEGLVSLRRKRLECFTDLWMTHSVKDLHTWADKLEMEEIQTSLPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MPRGKSASGGSTA --CCCCCCCCCCCCC	30.41	-
8	Phosphorylation	MPRGKSASGGSTAAG CCCCCCCCCCCCCCC	51.26	29899451
12	Phosphorylation	KSASGGSTAAGPGPG CCCCCCCCCCCCCCC	24.65	29899451
33	Phosphorylation	RFFRSAGSLRSSASS HHHHHHCCCCCCCCC	21.96	-
64	Acetylation	LGNGGPTKKKARKVP CCCCCCCHHHHCCCC	56.24	19850847
65	Acetylation	GNGGPTKKKARKVPE CCCCCCHHHHCCCCH	54.89	19850855
88	Acetylation	ASHHPEAKKCLRPRI HCCCHHHHHHCCCHH	42.21	19860995
89	Acetylation	SHHPEAKKCLRPRIV CCCHHHHHHCCCHHH	45.62	19861003
183	Phosphorylation	CKPFNKRSKSVYTPL CCCCCCCCCCCCCCH	30.78	22499769
185	Phosphorylation	PFNKRSKSVYTPLEL CCCCCCCCCCCCHHH	22.92	22499769
187	Phosphorylation	NKRSKSVYTPLELQY CCCCCCCCCCHHHHH	15.10	22499769
188	Phosphorylation	KRSKSVYTPLELQYL CCCCCCCCCHHHHHC	21.17	22499769
194	Phosphorylation	YTPLELQYLDMKQQH CCCHHHHHCCHHHHC	19.79	22499769
282	Phosphorylation	AIGDNKSSVFSRKLT HHCCCCHHHHHHHHH	28.88	24719451
285	Phosphorylation	DNKSSVFSRKLTALY CCCHHHHHHHHHHHH	26.75	24719451
330	Phosphorylation	TNYLLCIYEEKENIK CCEEEEEEECHHCCC	19.62	-
374	Phosphorylation	ASRLELETRISSLQP HHHHCHHHHHHHCCC	46.02	25777480
377	Phosphorylation	LELETRISSLQPVEL HCHHHHHHHCCCEEE	23.00	25777480
378	Phosphorylation	ELETRISSLQPVELL CHHHHHHHCCCEEEE	28.75	25777480
388	Phosphorylation	PVELLLPSDLSEPTE CEEEECCCCCCCCHH	51.67	25777480
391	Phosphorylation	LLLPSDLSEPTEMLI EECCCCCCCCHHHHH	46.66	25777480
394	Phosphorylation	PSDLSEPTEMLIQRA CCCCCCCHHHHHHHH	29.94	25777480
487	Phosphorylation	PESFKQLSSGMEFMR CHHHHHHHCCCEEEE	23.50	22006019
585	O-linked_Glycosylation	DVERGLCSIYHKKCS CHHCCCCHHHCCCCC	31.09	30059200

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSH3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSH3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSH3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MSH3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.