VPS51_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS51_MOUSE
• UniProt AC: Q3UVL4
• Protein Name: Vacuolar protein sorting-associated protein 51 homolog
• Gene Name: Vps51
• Organism: Mus musculus (Mouse).
• Sequence Length: 782
• Subcellular Localization: Golgi apparatus, trans-Golgi network . Recycling endosome . Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
• Protein Description: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane..
• Protein Sequence: MAAAAAVGPGLGSGPGDSPEGPEADAPERRRKAHGMLKLYYGLSEGEVAGHPAGPDPLDPTDLNGAHFDPEVYLDKLRRECPLAQLMDSETDMVRQIRALDSDMQTLVYENYNKFISATDTIRKMKNDFRKMEDEMDRLATNMAVITNFSARISATLQDRHERITKLAGVHALLRKLQFLFELPSRLTKCVELGAYGQAVRYQGRARAVLQQYQHLPSFRAIQDDCQVITARLAQQLRQRFREGCSGAPEQAECVELLLALGEPAEELCEEFLAHARGRLEEELSSLEAELGPSPPAPDVLEFTDRGGNGFVGGLCQVAAAYQELFAAQGPAGAEKLAAFAQELGGRYFALVERRLAQEQGGSDNSLLVRALDRFHRRLRAPGALLAAAGLSESATEIVERVARERLSHHLQGLKAAFLSSLTDVRQALAAPRLAGKEGPSLAELLANVASSILSHIKTSLASVHLFTAKEVSFSNKPYFRGEFCSQGVREGLIVGFIRSMCQTAQSFCDSPGEKGGATPPALLLLLSRLCLDYETATISYILTLTDEQFLVQDQSPVTPVSTLCAEARETARRLLTHYVKVQGLVISQMLRKSVETRDWLSTLEPRNVRAVMKRVVEDTTAIDVQVGLLYEEGVRKAQSSDSSKRTFSVYSSSRQQGRYAPSYTPSAPMDTNLLSNIQKLFSERIDVFSPVEFNKVSVLTGIIKISLKTLLECVRLRTFGRFGLQQVQVDCHFLQLYLWRFVADEELVHLLLDEVVASAALRCPDPVPMEPSVVEVICERG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAAAVGP ------CCCCCCCCC		-
13	Phosphorylation	AVGPGLGSGPGDSPE CCCCCCCCCCCCCCC		23984901
18	Phosphorylation	LGSGPGDSPEGPEAD CCCCCCCCCCCCCCC		26824392
40	Phosphorylation	AHGMLKLYYGLSEGE HHHHHHHHHCCCCCC		23984901
41	Phosphorylation	HGMLKLYYGLSEGEV HHHHHHHHCCCCCCC		23984901
44	Phosphorylation	LKLYYGLSEGEVAGH HHHHHCCCCCCCCCC		26643407
61	Phosphorylation	GPDPLDPTDLNGAHF CCCCCCCCCCCCCCC		23984901
294	Phosphorylation	LEAELGPSPPAPDVL HHHHHCCCCCCCCCE		29899451
441	Phosphorylation	LAGKEGPSLAELLAN HCCCCCCCHHHHHHH		22871156
451	Phosphorylation	ELLANVASSILSHIK HHHHHHHHHHHHHHH		22871156
640	Phosphorylation	EGVRKAQSSDSSKRT HCCCCCCCCCCCCCE		30352176
641	Phosphorylation	GVRKAQSSDSSKRTF CCCCCCCCCCCCCEE		30352176
643	Phosphorylation	RKAQSSDSSKRTFSV CCCCCCCCCCCEEEE		30352176
644	Phosphorylation	KAQSSDSSKRTFSVY CCCCCCCCCCEEEEE		20531401
647	Phosphorylation	SSDSSKRTFSVYSSS CCCCCCCEEEEEECC		28066266
649	Phosphorylation	DSSKRTFSVYSSSRQ CCCCCEEEEEECCCC		26060331
651	Phosphorylation	SKRTFSVYSSSRQQG CCCEEEEEECCCCCC		28066266
652	Phosphorylation	KRTFSVYSSSRQQGR CCEEEEEECCCCCCC		23684622
653	Phosphorylation	RTFSVYSSSRQQGRY CEEEEEECCCCCCCC		26060331
654	Phosphorylation	TFSVYSSSRQQGRYA EEEEEECCCCCCCCC		24899341
660	Phosphorylation	SSRQQGRYAPSYTPS CCCCCCCCCCCCCCC		24759943
663	Phosphorylation	QQGRYAPSYTPSAPM CCCCCCCCCCCCCCC		26643407
664	Phosphorylation	QGRYAPSYTPSAPMD CCCCCCCCCCCCCCC		29472430
665	Phosphorylation	GRYAPSYTPSAPMDT CCCCCCCCCCCCCCC		26643407
667	Phosphorylation	YAPSYTPSAPMDTNL CCCCCCCCCCCCCCH		26643407
672	Phosphorylation	TPSAPMDTNLLSNIQ CCCCCCCCCHHHHHH		26643407
676	Phosphorylation	PMDTNLLSNIQKLFS CCCCCHHHHHHHHHH		29472430
683	Phosphorylation	SNIQKLFSERIDVFS HHHHHHHHCCCCCCC		22324799
690	Phosphorylation	SERIDVFSPVEFNKV HCCCCCCCCCCCCHH		22324799

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS51_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS51_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS51_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VPS51_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.