ATP5I_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATP5I_MOUSE
• UniProt AC: Q06185
• Protein Name: ATP synthase subunit e, mitochondrial
• Gene Name: Atp5i
• Organism: Mus musculus (Mouse).
• Sequence Length: 71
• Subcellular Localization: Mitochondrion. Mitochondrion inner membrane.
• Protein Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane..
• Protein Sequence: MVPPVQVSPLIKFGRYSALIIGMAYGAKRYSYLKPRAEEERRIAAEEKKRLDELKRIERELAEAQDDSILK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MVPPVQVSPLIKFGR CCCCCCCCHHHHCCC	9.26	27841257
25	Phosphorylation	ALIIGMAYGAKRYSY HHHHHHHHCHHHHHC	14.55	-
28	Acetylation	IGMAYGAKRYSYLKP HHHHHCHHHHHCCCC	47.72	2388355
28	Succinylation	IGMAYGAKRYSYLKP HHHHHCHHHHHCCCC	47.72	26388266
30	Phosphorylation	MAYGAKRYSYLKPRA HHHCHHHHHCCCCHH	10.85	23140645
31	Phosphorylation	AYGAKRYSYLKPRAE HHCHHHHHCCCCHHH	28.20	23140645
32	Phosphorylation	YGAKRYSYLKPRAEE HCHHHHHCCCCHHHH	15.15	26032504
34	Acetylation	AKRYSYLKPRAEEER HHHHHCCCCHHHHHH	24.99	23576753
34	Ubiquitination	AKRYSYLKPRAEEER HHHHHCCCCHHHHHH	24.99	27667366
48	Acetylation	RRIAAEEKKRLDELK HHHHHHHHHHHHHHH	34.40	23864654
68	Phosphorylation	LAEAQDDSILK---- HHHHHCCCCCC----	37.80	25521595
71	Acetylation	AQDDSILK------- HHCCCCCC-------	57.53	23864654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATP5I_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATP5I_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATP5I_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ATP5I_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-32, AND MASSSPECTROMETRY.
PubMed: 18034455