CPNE6_MOUSE - dbPTM
CPNE6_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CPNE6_MOUSE
UniProt AC Q9Z140
Protein Name Copine-6 {ECO:0000305}
Gene Name Cpne6 {ECO:0000312|MGI:MGI:1334445}
Organism Mus musculus (Mouse).
Sequence Length 557
Subcellular Localization Cytoplasm . Cell membrane . Endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Perikaryon . Cell projection, dendrite . Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium (PubMed:9886090).
Protein Description Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. [PubMed: 9886090 Plays a role in dendrite formation by melanocytes (By similarity]
Protein Sequence MSDPEMGWVPEPPAMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLAIEYFFEEKQPLQFHVFDAEDGATSPSSDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAHKLDNKDLFSKSDPFMEIYKTNGDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDIHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRTVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPKGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPSTPAMTPSPSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDPEMGWV
------CCCCCCCCC		62.97-
65PhosphorylationERTEVLRSCSSPVFS
EHHHHHHHCCCHHHH		17.7522324799
67PhosphorylationTEVLRSCSSPVFSRV
HHHHHHCCCHHHHHH		38.6322324799
68PhosphorylationEVLRSCSSPVFSRVL
HHHHHCCCHHHHHHH		29.4322324799
99PhosphorylationFDAEDGATSPSSDTF
EECCCCCCCCCCCCC		46.8529899451
100PhosphorylationDAEDGATSPSSDTFL
ECCCCCCCCCCCCCC		23.4229899451
102PhosphorylationEDGATSPSSDTFLGS
CCCCCCCCCCCCCCC		40.3829899451
103PhosphorylationDGATSPSSDTFLGST
CCCCCCCCCCCCCCC		44.0120415495
105PhosphorylationATSPSSDTFLGSTEC
CCCCCCCCCCCCCCC		23.7820415495
109PhosphorylationSSDTFLGSTECTLGQ
CCCCCCCCCCCCHHH		24.1520415495
110PhosphorylationSDTFLGSTECTLGQI
CCCCCCCCCCCHHHH		33.0320415495
113PhosphorylationFLGSTECTLGQIVSQ
CCCCCCCCHHHHHHC		27.9120415495
119PhosphorylationCTLGQIVSQTKVTKP
CCHHHHHHCCCCCCC		33.4920415495
121PhosphorylationLGQIVSQTKVTKPLL
HHHHHHCCCCCCCEE		21.7020415495
171UbiquitinationDNKDLFSKSDPFMEI
CCHHHCCCCCCCCEE		52.0922790023
180UbiquitinationDPFMEIYKTNGDQSD
CCCCEEEECCCCHHH		40.9722790023
197UbiquitinationVWRTEVVKNNLNPSW
EEEEEHHHCCCCCCC		45.3422790023
322PhosphorylationASNGDPRSSQSLHCL
CCCCCCCCCCEEEEC		37.8122807455
323PhosphorylationSNGDPRSSQSLHCLS
CCCCCCCCCEEEECC		25.6821183079
325PhosphorylationGDPRSSQSLHCLSPR
CCCCCCCEEEECCCC		23.2520415495
330PhosphorylationSQSLHCLSPRQPNHY
CCEEEECCCCCCCHH		24.3522324799
355UbiquitinationCQDYDSDKRFPAFGF
CCCCCCCCCCCCCCC		60.9522790023
540PhosphorylationYYASQGISPGAPRPS
HHHHCCCCCCCCCCC		24.8929899451
547PhosphorylationSPGAPRPSTPAMTPS
CCCCCCCCCCCCCCC		48.5819060867
548PhosphorylationPGAPRPSTPAMTPSP
CCCCCCCCCCCCCCC		20.1125521595
552PhosphorylationRPSTPAMTPSPSP--
CCCCCCCCCCCCC--		23.7919060867
554PhosphorylationSTPAMTPSPSP----
CCCCCCCCCCC----		28.9219060867
556PhosphorylationPAMTPSPSP------
CCCCCCCCC------		47.8025521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CPNE6_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CPNE6_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CPNE6_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OS9_MOUSEOs9physical
10403379
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CPNE6_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.

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