OS9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OS9_MOUSE
• UniProt AC: Q8K2C7
• Protein Name: Protein OS-9
• Gene Name: Os9
• Organism: Mus musculus (Mouse).
• Sequence Length: 672
• Subcellular Localization: Endoplasmic reticulum lumen.
• Protein Description: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity)..
• Protein Sequence: MAAEVLLSSLLGLLFLGLLLPARLTGGVGSLNLEELSEMRYGIQILPLPVMGGQSQASDVVVVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGDVLYLGHYQSSFNWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGKPREAEVRFLCDEGAGISGDYIDRVDEPVSCSYVLTIRTSRLCPHPLLRPPASAAPQAILCHPALQPDEYMAYLQRQAESKQHEEKTTEEVQDTDRQVWSGSKAAGAPPKKEDVSPAKEEKESELWKLQGPEEQAAAREEAQAGEQDLNHEAAADPAPSPPNDFQNNVQVKLIRSPADLIRLIEELKAAEKGKPSVRREQPGDDTTEAPQREAEGTKAKGKDGEPPGLMEEEDGDDEEEEEEEEEDEEEQQLLGEFEKELEGMLLPSNRERLRSEVKAGMERELENIIQETEKELDPEGLRKESEREQAILALTSTLDKLIKRLQENQSPELVQKYKKRRVVPQKPPPSPHPTEEEPEHRVRVRVTKLRPGGPNRDLTVLEMNRENPQLKQIEGLVTEVLEREGLTAEGKIEIKIVRPGAEGKEEDTRWLTDEDTRNLKEIFFNILVQGAEEANKERQRQSELESNYRRVWGSPGGEDTGDLDEFDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Ubiquitination	RDAPCLLKTKDWWTY CCCCEEEECCCCEEH	40.35	22790023
177	N-linked_Glycosylation	YHSQTYGNGSKCDLN HHHCCCCCCCCCCCC	40.94	-
184	Ubiquitination	NGSKCDLNGKPREAE CCCCCCCCCCCCCEE	43.10	27667366
288	Ubiquitination	RQVWSGSKAAGAPPK HHHHCCCCCCCCCCC	45.86	27667366
296	Acetylation	AAGAPPKKEDVSPAK CCCCCCCCCCCCCCH	65.99	15610447
300	Phosphorylation	PPKKEDVSPAKEEKE CCCCCCCCCCHHHHH	31.31	28066266
344	Phosphorylation	AAADPAPSPPNDFQN HHCCCCCCCCCCCCC	55.91	30635358
448	Ubiquitination	FEKELEGMLLPSNRE HHHHHCCCCCCCCHH	2.25	27667366
462	Ubiquitination	ERLRSEVKAGMEREL HHHHHHHHHHHHHHH	34.86	22790023
478	Ubiquitination	NIIQETEKELDPEGL HHHHHHHHHCCHHHH	71.63	22790023
514	Phosphorylation	KRLQENQSPELVQKY HHHHHCCCHHHHHHH	31.74	27841257
520	Ubiquitination	QSPELVQKYKKRRVV CCHHHHHHHHHCCCC	52.11	22790023
552	Ubiquitination	RVRVRVTKLRPGGPN CEEEEEEECCCCCCC	39.37	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OS9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OS9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OS9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEP1B_RAT	Mep1b	physical	12093806
CPNE6_MOUSE	Cpne6	physical	10403379

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.