MEP1B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEP1B_RAT
• UniProt AC: P28826
• Protein Name: Meprin A subunit beta
• Gene Name: Mep1b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 704
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Secreted . Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.
• Protein Description: Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components..
• Protein Sequence: MDARHWPWFLVFATFLLVSGLPAPEKFVKDIDGGIDQDIFDINEDLGLDLFEGDIKLEASGRNSIIGDNYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWSGEENYISVFKGSGCWSSVGNIHAGKQELSIGTNCDRIATVQHEFLHALGFWHEQSRADRDDYITIVWDRILSGKEHNFNIYNDSVSDSLNVPYDYTSVMHYSKTAFQNGTESTIITKISDFEDVIGQRMDFSDYDLLKLNQLYSCTSSLSFMDSCDFELENICGMIQSSQDSADWQRLSQVLSGPENDHSNMGQCKDSGFFMHFNTSTGNGGVTAMLESRVLYPKRGFQCVEFYLYNSGSGNGQLNVYTREYTAGHQDGVLTLQREIRDIPTGSWQLYYVTLQVTEKFRVVFEGVGGPGASSGGLSIDDINLSETRCPHHIWHIQNFTQLLGGQTTVYSPPFYSSKGYAFQINLDLTSPTNVGLYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPKMTDDNGSYLWDRPSKVGVEAFFPNGTQFSRGRGYGTSVFITQERLKSREFLKGDDVYILLTVEDISHLNSTAAVPGPVPTTSTVHNACSEVECQNGGICTLQEGRAECKCPAGEDWWYMGKRCEKRGSTKDTIVIAVSSTVTVFAVMLIITLISVYCTRRKYRKKASAKTAAMNLENQHAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
193	N-linked_Glycosylation	EHNFNIYNDSVSDSL CCCCCCCCCCCCCCC	31.14	-
219	N-linked_Glycosylation	YSKTAFQNGTESTII EEEEHHCCCCEEEEE	53.56	-
316	N-linked_Glycosylation	SGFFMHFNTSTGNGG CCEEEEEEECCCCCC	20.59	-
422	N-linked_Glycosylation	GLSIDDINLSETRCP CCCCCCCCCCCCCCC	44.50	-
437	N-linked_Glycosylation	HHIWHIQNFTQLLGG CHHEEECCHHHHHCC	41.13	-
528	N-linked_Glycosylation	DPKMTDDNGSYLWDR CCCCCCCCCCCCCCC	44.09	-
547	N-linked_Glycosylation	GVEAFFPNGTQFSRG CCEEECCCCCCCCCC	62.07	-
592	N-linked_Glycosylation	VEDISHLNSTAAVPG EHHHHCCCCCCCCCC	31.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEP1B_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEP1B_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEP1B_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OS9_RAT	Os9	physical	12093806
OS9_MOUSE	Os9	physical	12093806

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.