EHD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EHD1_MOUSE
• UniProt AC: Q9WVK4
• Protein Name: EH domain-containing protein 1 {ECO:0000305}
• Gene Name: Ehd1 {ECO:0000312|MGI:MGI:1341878}
• Organism: Mus musculus (Mouse).
• Sequence Length: 534
• Subcellular Localization: Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle . Cell projectio
• Protein Description: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (By similarity). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. [PubMed: 15930129]
• Protein Sequence: MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISSGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQAVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLIPPSKRRHE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFSWVSKD -------CCCCCCHH	5.61	-
6	Phosphorylation	--MFSWVSKDARRKK --CCCCCCHHHHHHC	20.68	29514104
7	Acetylation	-MFSWVSKDARRKKE -CCCCCCHHHHHHCC	45.87	23806337
12	Ubiquitination	VSKDARRKKEPELFQ CCHHHHHHCCCHHHH	56.80	-
32	Ubiquitination	LRQLYAQKLLPLEEH HHHHHHHHHCCHHHH	43.76	-
47	Phosphorylation	YRFHEFHSPALEDAD HCHHCCCCCCCCCCC	19.72	22324799
58	Ubiquitination	EDADFDNKPMVLLVG CCCCCCCCCEEEEEE	36.01	-
124	Ubiquitination	DPRRPFRKLNAFGNA CCCCCCHHCHHHHHH	46.61	-
138	S-nitrosocysteine	AFLNRFMCAQLPNPV HHHHHHHHCCCCCCC	1.69	-
138	S-nitrosylation	AFLNRFMCAQLPNPV HHHHHHHHCCCCCCC	1.69	21278135
162	Ubiquitination	PGILSGEKQRISRGY CCCCCCCHHHHCCCC	48.69	-
205	Ubiquitination	DEFSEVIKALKNHED HHHHHHHHHHHCCHH	53.49	-
220	Ubiquitination	KIRVVLNKADQIETQ HHHHEEEHHHHHHHH	49.53	-
269	Ubiquitination	LLIPDNRKLFEAEEQ EECCCCHHHHHHHHH	64.88	-
280	Ubiquitination	AEEQDLFKDIQSLPR HHHHHHHHHHHHCCH	62.31	-
284	Phosphorylation	DLFKDIQSLPRNAAL HHHHHHHHCCHHHHH	40.45	22817900
293	Ubiquitination	PRNAALRKLNDLIKR CHHHHHHHHHHHHHH	53.12	-
299	Ubiquitination	RKLNDLIKRARLAKV HHHHHHHHHHHHHHH	47.50	-
299	Acetylation	RKLNDLIKRARLAKV HHHHHHHHHHHHHHH	47.50	7614661
305	Acetylation	IKRARLAKVHAYIIS HHHHHHHHHHHHHHH	38.86	15603757
324	Acetylation	EMPNVFGKESKKKEL HCCCCCCCHHHHHHH	47.56	15603765
326	Phosphorylation	PNVFGKESKKKELVN CCCCCCHHHHHHHHH	53.94	29514104
341	Ubiquitination	NLGEIYQKIEREHQI HHHHHHHHHHHHHCC	29.57	-
349	Phosphorylation	IEREHQISSGDFPSL HHHHHCCCCCCCHHH	23.00	28066266
350	Phosphorylation	EREHQISSGDFPSLR HHHHCCCCCCCHHHH	43.97	28066266
355	Phosphorylation	ISSGDFPSLRKMQEL CCCCCCHHHHHHHHH	40.58	26824392
358	Ubiquitination	GDFPSLRKMQELLQT CCCHHHHHHHHHHHC	50.67	-
370	Ubiquitination	LQTQDFSKFQALKPK HHCCCHHHHHHHCHH	41.30	-
377	Acetylation	KFQALKPKLLDTVDD HHHHHCHHHHHCHHH	61.16	23954790
426	Phosphorylation	NGPFGHGYGEGAGEG CCCCCCCCCCCCCCC	13.31	24224561
447	Phosphorylation	VVGKDKPTYDEIFYT EECCCCCCCCEEEEE	49.71	25619855
448	Phosphorylation	VGKDKPTYDEIFYTL ECCCCCCCCEEEEEC	21.80	25619855
453	Phosphorylation	PTYDEIFYTLSPVNG CCCCEEEEECCCCCC	16.66	25619855
454	Phosphorylation	TYDEIFYTLSPVNGK CCCEEEEECCCCCCE	15.26	25619855
456	Phosphorylation	DEIFYTLSPVNGKIT CEEEEECCCCCCEEC	20.99	25521595
479	Phosphorylation	VKSKLPNTVLGKIWK HHCCCCCCHHHHHHH	18.37	29176673
492	Acetylation	WKLADVDKDGLLDDE HHHHCCCCCCCCCHH	54.25	23806337
509	Ubiquitination	ALANHLIKVKLEGHE HHHHCEEEEEECCCC	39.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EHD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EHD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EHD1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EHD1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.