U5S1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: U5S1_MOUSE
• UniProt AC: O08810
• Protein Name: 116 kDa U5 small nuclear ribonucleoprotein component
• Gene Name: Eftud2
• Organism: Mus musculus (Mouse).
• Sequence Length: 971
• Subcellular Localization: Nucleus.
• Protein Description: Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP (By similarity)..
• Protein Sequence: MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEDEDEDEDDVGEHEDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPSSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLELAKQDVVLNYPM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDTDLYDE -------CCCHHHHH	12.97	-
3	Phosphorylation	-----MDTDLYDEFG -----CCCHHHHHCC	26.97	22668510
6	Phosphorylation	--MDTDLYDEFGNYI --CCCHHHHHCCCCC	19.08	23737553
12	Phosphorylation	LYDEFGNYIGPELDS HHHHCCCCCCCCCCC	13.97	23737553
19	Phosphorylation	YIGPELDSDEDDDEL CCCCCCCCCCCCCHH	56.37	22802335
30	Phosphorylation	DDELGRETKDLDEDE CCHHCHHCCCCCCCC	28.62	23737553
78	Phosphorylation	VYGPEVETIVQEEDT HHCCCCEEEEECCCC	31.46	21149613
85	Phosphorylation	TIVQEEDTQPLTEPI EEEECCCCCCCCCCC	35.05	21149613
89	Phosphorylation	EEDTQPLTEPIIKPV CCCCCCCCCCCCCCC	46.53	21149613
97	Ubiquitination	EPIIKPVKTKKFTLM CCCCCCCCCCCEEEC	64.25	-
253	Phosphorylation	VQERLAVTVCINKID HHHHHCCEEHHHHHC	12.21	18779572
313	Phosphorylation	VCFSSSQYSICFTLG CCCCCCCEEEEEEHH	11.27	-
351	Ubiquitination	GDIYFNPKTRKFTKK CCEECCCCCCCCCCC	63.16	-
404	Ubiquitination	ELGIHLTKEELKLNI HHCCCCCHHHHHCCH	56.40	-
408	Ubiquitination	HLTKEELKLNIRPLL CCCHHHHHCCHHHHH	42.65	-
458	Phosphorylation	TYTGGVDSDLGEAMS EEECCCCCCHHHHHH	32.12	25619855
465	Phosphorylation	SDLGEAMSDCDPDGP CCHHHHHHCCCCCCC	41.98	25619855
647	Phosphorylation	MHDLRKMYSEIDIKV HHHHHHHHHHCCEEE	13.24	18779572
648	Phosphorylation	HDLRKMYSEIDIKVA HHHHHHHHHCCEEEC	25.28	18779572
712	Ubiquitination	QITWNRKKLGEFFQT EEEECHHHHHHHHHC	59.49	-
943	Phosphorylation	TRRRKGLSEDVSISK HCCCCCCCCCCCHHH	40.18	28833060
947	Phosphorylation	KGLSEDVSISKFFDD CCCCCCCCHHHHCCC	33.20	28833060
949	Phosphorylation	LSEDVSISKFFDDPM CCCCCCHHHHCCCHH	18.86	28833060
950	Ubiquitination	SEDVSISKFFDDPML CCCCCHHHHCCCHHH	48.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of U5S1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of U5S1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of U5S1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of U5S1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.