dbPTM

RRS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RRS1_MOUSE
UniProt AC	Q9CYH6
Protein Name	Ribosome biogenesis regulatory protein homolog
Gene Name	Rrs1
Organism	Mus musculus (Mouse).
Sequence Length	365
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus..
Protein Sequence	MEGQRVEELLAKAEQEEAEKLQRITVHKELELEFDLGNLLASDRNPPTVLRQAGPSPEAELRALARDNTQLLINQLWRLPTERVEEAVVARLPEPATRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEASGQWRRRWGYKRARDDTKEWLIEVPGSADPMEDQFAKRTQAKKERVAKNELNRLRNLARAHKMQMPSSAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKAPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPRLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPSGKRKGGPPGQGEKRKGGLGSKKHSWPSALAGKKKGVPPQGGKRRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGQRVEE -------CCCHHHHH	13.57	-
12	Acetylation	RVEELLAKAEQEEAE HHHHHHHHHHHHHHH	53.04	23806337
56	Phosphorylation	VLRQAGPSPEAELRA HHHHCCCCHHHHHHH	34.16	26824392
163	Phosphorylation	WLIEVPGSADPMEDQ EEEECCCCCCHHHHH	24.35	26745281
251	Acetylation	APRGSGKKRKFQPLF CCCCCCCCCCCHHHH	65.43	7614599
265	Ubiquitination	FGDFAAEKKNQLELL HCHHHHHHHHHHHHH	52.91	-
273	Citrullination	KNQLELLRVMNSKKP HHHHHHHHHHCCCCC	37.96	-
273	Citrullination	KNQLELLRVMNSKKP HHHHHHHHHHCCCCC	37.96	24463520
340	Phosphorylation	KRKGGLGSKKHSWPS CCCCCCCCCCCCCCH	43.50	22817900
344	Phosphorylation	GLGSKKHSWPSALAG CCCCCCCCCCHHHCC	49.95	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RRS1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RRS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RRS1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RRS1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RRS1_MOUSE

Related Literatures of Post-Translational Modification