PDIA6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDIA6_MOUSE
• UniProt AC: Q922R8
• Protein Name: Protein disulfide-isomerase A6
• Gene Name: Pdia6
• Organism: Mus musculus (Mouse).
• Sequence Length: 440
• Subcellular Localization: Endoplasmic reticulum lumen . Cell membrane . Melanosome .
• Protein Description: May function as a chaperone that inhibits aggregation of misfolded proteins. [PubMed: 24508390 Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity]
• Protein Sequence: MARLVLGLVSCTFFLAVSGLYSSSDDVIELTPSNFNREVIQSDGLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGSFPTITPREPWDGKDGELPVEDDIDLSDVELDDLEKDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	PEWKKAATALKDVVK HHHHHHHHHHHHHHH	37.06	18779572
77	Ubiquitination	TALKDVVKVGAVNAD HHHHHHHHCCCCCCC	34.50	-
85	Ubiquitination	VGAVNADKHQSLGGQ CCCCCCCCCHHHCCC	40.93	-
88	Phosphorylation	VNADKHQSLGGQYGV CCCCCCHHHCCCCCC	28.80	26824392
129	Phosphorylation	AIVDAALSALRQLVK HHHHHHHHHHHHHHH	22.11	27180971
143	Phosphorylation	KDRLGGRSGGYSSGK HHHHCCCCCCCCCCC	39.58	25195567
146	Phosphorylation	LGGRSGGYSSGKQGR HCCCCCCCCCCCCCC	11.82	25195567
147	Phosphorylation	GGRSGGYSSGKQGRG CCCCCCCCCCCCCCC	35.57	25195567
148	Phosphorylation	GRSGGYSSGKQGRGD CCCCCCCCCCCCCCC	41.34	25195567
150	Acetylation	SGGYSSGKQGRGDSS CCCCCCCCCCCCCCC	52.07	7970497
156	Phosphorylation	GKQGRGDSSSKKDVV CCCCCCCCCCCCCEE	39.06	-
158	Phosphorylation	QGRGDSSSKKDVVEL CCCCCCCCCCCEEEC	47.91	-
166	Phosphorylation	KKDVVELTDDTFDKN CCCEEECCCCCCCCC	20.51	26525534
169	Phosphorylation	VVELTDDTFDKNVLD EEECCCCCCCCCCCC	36.22	26525534
230	Phosphorylation	TVNQVLASRYGIKGF HHHHHHHHHHCCCCC	23.13	-
248	Phosphorylation	KIFQKGESPVDYDGG EEEECCCCCCCCCCC	38.60	-
257	Phosphorylation	VDYDGGRTRSDIVSR CCCCCCCCHHHHHHH	37.49	19854140
259	Phosphorylation	YDGGRTRSDIVSRAL CCCCCCHHHHHHHHH	30.95	19854140
373	Ubiquitination	KMKFALLKGSFSEQG HHCEEHHHCCCCHHH	54.05	-
375	Phosphorylation	KFALLKGSFSEQGIN CEEHHHCCCCHHHHH	24.82	27742792
377	Phosphorylation	ALLKGSFSEQGINEF EHHHCCCCHHHHHHH	30.61	27742792
394	Phosphorylation	ELSFGRGSTAPVGGG HHHCCCCCCCCCCCC	21.75	28464351
428	Phosphorylation	VEDDIDLSDVELDDL CCCCCCHHHCCHHHH	35.54	24925903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDIA6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDIA6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDIA6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PDIA6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428, AND MASSSPECTROMETRY.
PubMed: 19144319