PDLI7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDLI7_MOUSE
• UniProt AC: Q3TJD7
• Protein Name: PDZ and LIM domain protein 7
• Gene Name: Pdlim7
• Organism: Mus musculus (Mouse).
• Sequence Length: 457
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity)..
• Protein Description: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)..
• Protein Sequence: MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLNIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKALTPPADPPRYTFAPSASLNKTARPFGAPPPTDSTLRQNGQLLRQPVPDASKQRLMEDTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEFMKKSSQVPRTEAPAPASTIPQESWPGPTTPSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQNRTSIVQAAAGGGTGGGSNNGKTPVCHQCHKIIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPSCYDVRYAPNCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGAPYCERDYEKMFGTKCRGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDKPLCKSHAFSHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Ubiquitination	GFRLQGGKDFNVPLS CEEECCCCCCCCCEE	67.00	-
78	Phosphorylation	RACGERLSLGLSRAQ HHHHHHHHHCCCCCC	26.98	26824392
96	Phosphorylation	SKPQKALTPPADPPR CCCCCCCCCCCCCCC	31.89	26824392
99 (in isoform 2)	Ubiquitination	-	43.05	-
103	Methylation	TPPADPPRYTFAPSA CCCCCCCCCCCCCCC	48.81	80702637
103	Asymmetric dimethylarginine	TPPADPPRYTFAPSA CCCCCCCCCCCCCCC	48.81	-
104	Phosphorylation	PPADPPRYTFAPSAS CCCCCCCCCCCCCCC	16.39	23984901
105	Phosphorylation	PADPPRYTFAPSASL CCCCCCCCCCCCCCC	18.01	29514104
109	Phosphorylation	PRYTFAPSASLNKTA CCCCCCCCCCCCCCC	27.36	26824392
111	Phosphorylation	YTFAPSASLNKTARP CCCCCCCCCCCCCCC	36.49	26824392
161	Phosphorylation	DWRPRPGTGQSRSFR CCCCCCCCCCCCEEE	34.43	26824392
166 (in isoform 2)	Phosphorylation	-	24.91	28542873
180 (in isoform 2)	Phosphorylation	-	65.49	22210690
188 (in isoform 2)	Phosphorylation	-	55.62	22210690
209	Phosphorylation	ASTIPQESWPGPTTP CCCCCCCCCCCCCCC	33.07	26643407
214	Phosphorylation	QESWPGPTTPSPTSR CCCCCCCCCCCCCCC	58.20	21659605
215	Phosphorylation	ESWPGPTTPSPTSRP CCCCCCCCCCCCCCC	25.54	26824392
217	Phosphorylation	WPGPTTPSPTSRPPW CCCCCCCCCCCCCCC	38.42	26824392
219	Phosphorylation	GPTTPSPTSRPPWAV CCCCCCCCCCCCCCC	41.53	26643407
220	Phosphorylation	PTTPSPTSRPPWAVD CCCCCCCCCCCCCCC	46.29	26643407
234	Phosphorylation	DPAFAERYAPDKTST CHHHHHHHCCCCCCC	17.62	26160508
238	Acetylation	AERYAPDKTSTVLTR HHHHCCCCCCCEEEE	43.23	23806337
239	Phosphorylation	ERYAPDKTSTVLTRH HHHCCCCCCCEEEEC	36.69	26160508
240	Phosphorylation	RYAPDKTSTVLTRHS HHCCCCCCCEEEECC	23.43	24719451
241	Phosphorylation	YAPDKTSTVLTRHSQ HCCCCCCCEEEECCC	25.43	26160508
244	Phosphorylation	DKTSTVLTRHSQPAT CCCCCEEEECCCCCC	23.23	26160508
247	Phosphorylation	STVLTRHSQPATPTP CCEEEECCCCCCCCC	34.27	26824392
251	Phosphorylation	TRHSQPATPTPLQNR EECCCCCCCCCCCCC	34.09	27087446
253	Phosphorylation	HSQPATPTPLQNRTS CCCCCCCCCCCCCCC	32.07	25619855
259	Phosphorylation	PTPLQNRTSIVQAAA CCCCCCCCCEEEECC	30.29	28285833
260	Phosphorylation	TPLQNRTSIVQAAAG CCCCCCCCEEEECCC	19.95	22817900
270	Phosphorylation	QAAAGGGTGGGSNNG EECCCCCCCCCCCCC	35.61	28973931
372	Phosphorylation	FTCAACKTPIRNRAF HHHHHCCCCCCCCEE	24.67	-
451	Phosphorylation	KDKPLCKSHAFSHV- CCCCCCHHCCCCCC-	21.03	23375375
455	Phosphorylation	LCKSHAFSHV----- CCHHCCCCCC-----	24.91	23375375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDLI7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDLI7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDLI7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH2B2_MOUSE	Sh2b2	physical	15946664

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.