XPO7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XPO7_MOUSE
• UniProt AC: Q9EPK7
• Protein Name: Exportin-7
• Gene Name: Xpo7
• Organism: Mus musculus (Mouse).
• Sequence Length: 1087
• Subcellular Localization: Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Shuttles between the nucleus and the cytoplasm..
• Protein Description: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity)..
• Protein Sequence: MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPDVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKVITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALENALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNRESDCFLHIMQQHPAMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVNSNDMMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADHVQSLA ------CHHHHHHHH	27.24	-
40	Phosphorylation	ALVEFTNSPDCLSKC HHHHCCCCHHHHHHH	21.03	24723360
55	Phosphorylation	QLLLERGSSSYSQLL HHHHHCCCCCHHHHH	23.49	22871156
57	Phosphorylation	LLERGSSSYSQLLAA HHHCCCCCHHHHHHH	30.42	22871156
59	Phosphorylation	ERGSSSYSQLLAATC HCCCCCHHHHHHHHH	19.12	22871156
69	Ubiquitination	LAATCLTKLVSRTNN HHHHHHHHHHHCCCC	33.66	-
117	Ubiquitination	QLYARITKLGWFDCQ HHHHHHHHHCCCCCC	42.50	22790023
338	Ubiquitination	CRLLARLKSNYQLGE HHHHHHHHHHCCCCC	30.97	22790023
397	Phosphorylation	SVPYVKATEPHMLET CCCCEECCCCCHHCC	44.31	25338131
404	Phosphorylation	TEPHMLETYTPEVTK CCCCHHCCCCHHHHH	28.83	25338131
569	Phosphorylation	IGDQVQKSSKLYRRL CCHHHHHHHHHHHHH	18.66	23684622
570	Phosphorylation	GDQVQKSSKLYRRLS CHHHHHHHHHHHHHH	33.44	25338131
626	Phosphorylation	DLSIGYSSVRKLVKL HCCCCHHHHHHHHHH	19.91	29109428
737	Phosphorylation	AFAFNAKTSFMMLFE HHHHCCCHHHHHHHH	25.45	24759943
738	Phosphorylation	FAFNAKTSFMMLFEW HHHCCCHHHHHHHHH	15.50	24759943
762	Phosphorylation	QRAIELWYHDPACTT HHHHHHHCCCHHCCH	14.68	24759943
768	Phosphorylation	WYHDPACTTPVLKLM HCCCHHCCHHHHHHH	35.92	24759943
769	Phosphorylation	YHDPACTTPVLKLMA CCCHHCCHHHHHHHH	15.98	24759943
883	Phosphorylation	PHSDLLDYPKLSQSY CCHHHCCCHHHCHHH	11.39	17242355

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XPO7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XPO7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XPO7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of XPO7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.