XPP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XPP1_MOUSE
• UniProt AC: Q6P1B1
• Protein Name: Xaa-Pro aminopeptidase 1
• Gene Name: Xpnpep1 {ECO:0000312|EMBL:AAH65174.1, ECO:0000312|MGI:MGI:2180003}
• Organism: Mus musculus (Mouse).
• Sequence Length: 623
• Subcellular Localization: Cytoplasm.
• Protein Description: Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity)..
• Protein Sequence: MAPKVTSELLRQLRQAMRNSEYVAEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDNNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLVPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKEKVADLRLKMAERSIAWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIVGLETIMLFIDGDRVDAPGVKQHLLLDLGLEAEYRIQVLPYKSILSELKALCADLSPREKVWVSDKASYAVSEAIPKDHRCCMPYTPICIAKAVKNSAESDGMRRAHIKDAVALCELFNWLEQEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKTKYNFNNRGSLTFEPLTLVPIQTKMIDVNALTDKECDWLNSYHQTCRDVVGKELQSQGRQEALEWLIRETEPVSRQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
130	Acetylation	IIPTDYWKKMAKVLR ECCHHHHHHHHHHHH	26.83	69553
130	Succinylation	IIPTDYWKKMAKVLR ECCHHHHHHHHHHHH	26.83	-
131	Acetylation	IPTDYWKKMAKVLRS CCHHHHHHHHHHHHH	29.91	134219
269	Acetylation	RIQVLPYKSILSELK EEEEECHHHHHHHHH	29.13	-
276	Ubiquitination	KSILSELKALCADLS HHHHHHHHHHHCCCC	34.95	-
287	Acetylation	ADLSPREKVWVSDKA CCCCCCCCEEECCHH	42.55	-
304	Acetylation	AVSEAIPKDHRCCMP HHHHHCCCCCCCCCC	61.11	22631845
405	Phosphorylation	PVPETNRTLSLDEVY CCCCCCCEECCCEEE	23.83	22871156
416	Phosphorylation	DEVYLIDSGAQYKDG CEEEEECCCCCCCCC	29.09	22871156
425	Phosphorylation	AQYKDGTTDVTRTMH CCCCCCCCCEEEEEE	33.72	22871156
435	Phosphorylation	TRTMHFGTPTAYEKE EEEEECCCCCCCCHH	19.27	29514104
441	Ubiquitination	GTPTAYEKECFTYVL CCCCCCCHHHHHHHH	47.29	-
441	Acetylation	GTPTAYEKECFTYVL CCCCCCCHHHHHHHH	47.29	-
502	Glutathionylation	LNVHEGPCGISYKTF EEECCCCCCCEEEEC	12.74	24333276
508	Phosphorylation	PCGISYKTFSDEPLE CCCCEEEECCCCCCC	21.82	29899451
510	Phosphorylation	GISYKTFSDEPLEAG CCEEEECCCCCCCCC	46.42	29899451
521	Phosphorylation	LEAGMIVTDEPGYYE CCCCCEEECCCCCCC	24.58	29899451
546	Ubiquitination	VVLVVPAKTKYNFNN EEEEEECCCEECCCC	39.21	-
549	Phosphorylation	VVPAKTKYNFNNRGS EEECCCEECCCCCCC	30.16	26745281
556	Phosphorylation	YNFNNRGSLTFEPLT ECCCCCCCEEEECCE	22.46	28066266
558	Phosphorylation	FNNRGSLTFEPLTLV CCCCCCEEEECCEEE	27.87	28066266
578	Phosphorylation	MIDVNALTDKECDWL EECHHHCCHHCCHHH	42.48	26525534

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XPP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XPP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XPP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of XPP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.