ZN516_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN516_MOUSE
• UniProt AC: Q7TSH3
• Protein Name: Zinc finger protein 516 {ECO:0000312|MGI:MGI:2443957}
• Gene Name: Znf516 {ECO:0000250|UniProtKB:Q92618}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1157
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress (By similarity)..
• Protein Sequence: MDRSREAEMELRRGPSPPRAGRSHEVDGDKAACHSCCICGKSFPFQSSLSQHMRKHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGHEPEAGEAQLGEMRVSEGLDGCASPTKSTSACNRVLNGAVPMDGSKILLRSSRKEVEGAASAQEDTEATVPCSFCKSRFERKKDLELHVHQAHKPFKCRLCSYVTLREESLLSHIERDHITAQVPNGSEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHICGRRFKEPWFLKNHMKAHGPKAGSKNRPKSELDPIATINNVVQEEVIVAGLSLYEVCTKCGNLFTNLDSLNAHNAIHRKVEASRIRAPAEEGDSEDPLDTKQFFLQCLNLTPYVAGDVSPGGQAGRRVAELDPVNSYQAWQLATRGKVAEPAEYLKYGTWDEALAGDVAFDKDKREYILVSQEKRKREQDAPATQAPPRKRASVPGDPMLSGHLDPRPTSRPNRRASATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRDRDPEGDRAARARCGSLSEGDSASQPSSPGSACAIADSPGLAEEVVDDSGEEAVPEPASGGQPRHCCSSGEVTPTALSNGDQNHKLGNNLPEKDISEPKVGSAMPSVSILENSSRETTKGPEQHRYSLDLKMPAFHPKQEVPSTTDRVDFPASMEITSLQHTLDSQAGHSKEKLSDLHKEHCGVGKRASAPDLVPLDLSMRSSRDEPSGKEACSLQAALVIHPCPYCTHKTYYPEVLWMHKRIWHRVSCSSVAPPWTQPSGHKSIRSNLVFLTRSGRTGPPPALGGKECQPLLLSRFARTQVPGGAPGSKGSSSPLGVTTKAASMPKNKESHSGGPCALWASGPDGYRQTRAGHGQEPPSAAVQGPLAKPKQEGSSRLAPSPGSGSLSRSTTPTPSVITRVGAQPSANSKPVEKLGGPAVGTGFTPPNKHSAPDSLKAKFSPQPQGQPPLKGEGGSPLPPREPSVKAAQELRTLATCAAGSRGEAALQAPPGAPPTLNSAKQEPAAEGQEKRLDILSIFKTYIPKDFATLYQGWGVSSPGPEHRGTSLTGTPRTQAHQGDFVCVECGKSFHQPSQLRAHLRAHTVVFECDGPRDSEVHTASTDAPKQGRDHTTPGTVPAGPLRKGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	MELRRGPSPPRAGRS HHHHCCCCCCCCCCC	50.81	29472430
116	Phosphorylation	EGLDGCASPTKSTSA CCCCCCCCCCCCHHH	36.86	25521595
118	Phosphorylation	LDGCASPTKSTSACN CCCCCCCCCCHHHHH	34.82	25159016
120	Phosphorylation	GCASPTKSTSACNRV CCCCCCCCHHHHHHH	30.03	22942356
351	Phosphorylation	IHRKVEASRIRAPAE HHHHHHHHHCCCCCC	18.09	22802335
379	Phosphorylation	FLQCLNLTPYVAGDV HHHHHCCCCEECCCC	16.11	23984901
381	Phosphorylation	QCLNLTPYVAGDVSP HHHCCCCEECCCCCC	9.55	23984901
387	Phosphorylation	PYVAGDVSPGGQAGR CEECCCCCCCCHHCC	23.67	23984901
599	Phosphorylation	GQPRHCCSSGEVTPT CCCCCCCCCCCCCCC	46.93	21659605
600	Phosphorylation	QPRHCCSSGEVTPTA CCCCCCCCCCCCCCC	25.67	21659605
604	Phosphorylation	CCSSGEVTPTALSNG CCCCCCCCCCCCCCC	15.60	30635358
606	Phosphorylation	SSGEVTPTALSNGDQ CCCCCCCCCCCCCCC	30.75	30635358
609	Phosphorylation	EVTPTALSNGDQNHK CCCCCCCCCCCCCCC	35.98	30635358
648	Phosphorylation	LENSSRETTKGPEQH EECCCCCCCCCCCCC	32.47	28576409
657	Phosphorylation	KGPEQHRYSLDLKMP CCCCCCCCEEECCCC	16.09	26060331
658	Phosphorylation	GPEQHRYSLDLKMPA CCCCCCCEEECCCCC	18.50	26060331
720	Phosphorylation	CGVGKRASAPDLVPL CCCCCCCCCCCCEEC	44.35	26824392
730	Phosphorylation	DLVPLDLSMRSSRDE CCEECCCHHCCCCCC	16.30	29899451
840	Phosphorylation	VPGGAPGSKGSSSPL CCCCCCCCCCCCCCC	32.55	27841257
843	Phosphorylation	GAPGSKGSSSPLGVT CCCCCCCCCCCCCCC	31.23	29472430
844	Phosphorylation	APGSKGSSSPLGVTT CCCCCCCCCCCCCCC	44.64	30635358
845	Phosphorylation	PGSKGSSSPLGVTTK CCCCCCCCCCCCCCC	26.33	26824392
850	Phosphorylation	SSSPLGVTTKAASMP CCCCCCCCCCCCCCC	22.30	24759943
881	Phosphorylation	GPDGYRQTRAGHGQE CCCCCCCCCCCCCCC	17.31	22802335
891	Phosphorylation	GHGQEPPSAAVQGPL CCCCCCCCHHHCCCC	39.31	22802335
907	Phosphorylation	KPKQEGSSRLAPSPG CCCCCCCCCCCCCCC	42.02	22802335
912	Phosphorylation	GSSRLAPSPGSGSLS CCCCCCCCCCCCCCC	35.96	26824392
915	Phosphorylation	RLAPSPGSGSLSRST CCCCCCCCCCCCCCC	28.70	29233185
917	Phosphorylation	APSPGSGSLSRSTTP CCCCCCCCCCCCCCC	25.52	29233185
919	Phosphorylation	SPGSGSLSRSTTPTP CCCCCCCCCCCCCCC	26.36	29233185
921	Phosphorylation	GSGSLSRSTTPTPSV CCCCCCCCCCCCCCE	33.00	25619855
922	Phosphorylation	SGSLSRSTTPTPSVI CCCCCCCCCCCCCEE	35.37	25619855
923	Phosphorylation	GSLSRSTTPTPSVIT CCCCCCCCCCCCEEE	26.81	26824392
925	Phosphorylation	LSRSTTPTPSVITRV CCCCCCCCCCEEEEE	26.55	25619855
927	Phosphorylation	RSTTPTPSVITRVGA CCCCCCCCEEEEECC	28.73	25619855
930	Phosphorylation	TPTPSVITRVGAQPS CCCCCEEEEECCCCC	19.69	25168779
937	Phosphorylation	TRVGAQPSANSKPVE EEECCCCCCCCCCCH	28.18	30387612
953	Phosphorylation	LGGPAVGTGFTPPNK HCCCCCCCCCCCCCC	23.64	28066266
956	Phosphorylation	PAVGTGFTPPNKHSA CCCCCCCCCCCCCCC	38.90	26239621
972	Phosphorylation	DSLKAKFSPQPQGQP CHHHCCCCCCCCCCC	23.17	29472430
987	Phosphorylation	PLKGEGGSPLPPREP CCCCCCCCCCCCCCC	33.83	27841257
1068	Phosphorylation	LYQGWGVSSPGPEHR HHCCCCCCCCCCCCC	27.20	28066266
1069	Phosphorylation	YQGWGVSSPGPEHRG HCCCCCCCCCCCCCC	31.31	28066266
1126	Phosphorylation	ECDGPRDSEVHTAST ECCCCCCCCCEECCC	42.68	24719451
1130	Phosphorylation	PRDSEVHTASTDAPK CCCCCCEECCCCCCC	27.72	24719451
1132	Phosphorylation	DSEVHTASTDAPKQG CCCCEECCCCCCCCC	28.16	25521595
1133	Phosphorylation	SEVHTASTDAPKQGR CCCEECCCCCCCCCC	33.44	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN516_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN516_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN516_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN516_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.